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Get the answers to common queries about CoQ10 deficiency symptoms, including how CoQ10 affects various health functions and the best way to enhance the CoQ10 level in your body. Use the links below to jump ahead to different topics on the page.

What Is CoQ10 and Where Is It Found? Potential Therapeutic Applications of CoQ10
How Does CoQ10 Support Cardiovascular Health? How Does CoQ10 Promote Healthy Skin?
CoQ10 Deficiency Symptoms Incorporating A Diet Rich In CoQ10
Factors Affecting CoQ10 Absorption In The Body Types of CoQ10 Supplement Formulations
FAQs: Frequently Asked Questions

What Is CoQ10 and Where Is It Found?

Coenzyme Q10, or CoQ10, is an endogenous compound prevalent in all tissues and organs in your body and is mainly biosynthesized and concentrated in tissues with high energy turnover. As a naturally occurring quinone, CoQ10 is found in most aerobic organisms—from bacteria to mammals. This lipid antioxidant, also referred to as ubiquinone, is critical for producing adenosine triphosphate (ATP), the source of cellular energy production.

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Potential Therapeutic Applications of CoQ10

Because CoQ10 is involved in cellular energy production, it is abundantly present in those organs that have a high metabolism rate, such as the heart, lungs, liver, kidneys, spleen, pancreas, and adrenal glands. In addition to its role as an energy transfer molecule in the electron transport chain, CoQ10 exerts therapeutic effects as an antioxidant, thereby supporting muscles, neurological health, cardiovascular health, cognitive health, skin health, oral health, and reproductive health.

The following table summarizes some of the key therapeutic applications of CoQ10.     

System Therapeutic Applications
Cardiovascular Health
Skin Health
Reproductive Health
  • CoQ10 Benefits for Women
  • CoQ10’s Menstrual Cycle Effects
Immune Health

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How Does CoQ10 Support Cardiovascular Health? 

The highest level of CoQ10 is found in heart muscle tissues. Various studies have established the benefits of CoQ10 on heart and muscle tissues for optimal cardiovascular health. The following table highlights some of the potential benefits of CoQ10 for your heart.    

CoQ10’s Potential Cardiovascular Health Benefits
Suppressing oxidative stress: Individuals affected with certain heart conditions have increased biomarkers of oxidative stress in their plasma. CoQ10 supplementation has been found1 to help maintain healthy levels of inflammatory biomarkers. Helping maintain normal blood pressure: Clinical trials have suggested the potential role of CoQ10 in helping maintain normal systolic blood pressure. 
Improving lipid profiles: CoQ10 supplementation has been found to improve lipid profiles, helping to maintain optimal total cholesterol levels and elevating high-density lipoprotein (HDL)-cholesterol levels. Addressing side effects of statin intake: Statin medications to lower cholesterol levels can cause statin-associated myopathy, such as muscle aches and weakness, which are attributed to CoQ10 depletion and can be addressed with CoQ10 supplementation.

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How Does CoQ10 Promote Healthy Skin? 

The skin, being exposed to both extrinsic and intrinsic stress factors, is more prone to oxidative stress and requires a high amount of cellular energy for the regeneration and repair of tissues. The antioxidant properties of CoQ10 help support optimal skin health, especially in the dermis layer. CoQ10 promotes healthy skin by:

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CoQ10 Deficiency Symptoms

CoQ10 levels in the body can become depleted with age, under the influence of certain medications, and with different pathological conditions. Primary CoQ10 deficiency resulting in a low CoQ10 level can be a direct result of poor biosynthesis of the antioxidant in the body, which can be addressed through the supplementation of high-dose CoQ10. Secondary CoQ10 deficiencies are caused by pathogenic variants in genes that are not directly involved in CoQ10 biosynthesis. Molecular genetic testing is the only way to distinguish between a primary and secondary CoQ10 deficiency. The following are several of the common CoQ10 deficiency symptoms. 

CoQ10 Deficiency Symptoms
Muscle weakness and crampingStatin medications to address high cholesterol levels can lower circulating CoQ10, resulting in muscle aches and cramping. 
Exercise intoleranceLipid accumulation and mitochondrial proliferation can lead to weakness and exercise intolerance. 
TirednessWith low amounts of cellular energy due to a depleting level of CoQ10, affected individuals can experience tiredness. 
Poor eyesightBlurred vision caused by gradual damage to the blood vessels in retinal tissues and optic nerves might also result from a CoQ10 deficiency. 
Hearing lossHearing loss is common among individuals suffering from a CoQ10 deficiency.  
Cognitive impairmentPoor cognitive performance can be associated with a CoQ10 deficiency. 
NeurodegenerationVarious neurodegenerative conditions, including brain dysfunction, are associated with low levels of CoQ10. 
Gum diseasePeriodontal diseases, including swollen and tender gums, toothache or loose teeth, and bad breath are associated with CoQ10 deficiency. 

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Incorporating A Diet Rich in CoQ10

The whole body content of CoQ10 is only about 500 - 1,500 milligrams. 

Your body will normally produce sufficient CoQ10 with a balanced diet rich in CoQ foods. Research studies suggest that dietary CoQ10 contributes to enhancing plasma CoQ10 concentrations. As a fat-soluble molecule, CoQ10 is better absorbed when taken with a fatty meal. Some CoQ10-rich foods that are easy to include in your diet are:

CoQ10-Rich Food
Meat and Fish Organ meats, such as liver and kidney, and fatty fish, including salmon, tuna, and mackerel 
Fruits and Vegetables Strawberries, oranges, broccoli, cauliflower
Nuts and Seeds Sesame seeds, peanuts, pistachios
Legumes and Whole Grains Lentils, soybeans, whole grains
Oils Soybean oil, canola oil

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Factors Affecting CoQ10 Absorption in the Body

The therapeutic effects of CoQ10 can be hindered by its poor absorption and bioavailability in the body. Some of the key factors affecting CoQ10 absorption in the body are: 

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Types of Oral CoQ10 Supplement Formulations

Supplement formulations have been developed to address the challenges of CoQ10’s poor bioavailability and absorption. 

The average daily intake of CoQ10 from the diet is only 3 - 6 milligrams.

CoQ10 exists in the body in oxidized form (ubiquinone) and reduced form (ubiquinol). These two forms are continuously inter-converted within cells as part of the normal function of CoQ10. As CoQ10 is transported in the blood in ubiquinol form, it is commonly assumed that ingestion of CoQ10 supplements in ubiquinol form would facilitate the absorption process. However, ubiquinol is unstable and oxidizes to ubiquinone. Recent advancements in encapsulation techniques have made it possible to produce CoQ10 supplements in the ubiquinol form. 

Regular intake of 200 mg2 of CoQ10 daily is recommended to achieve a therapeutic blood level of 2.5 mcg/ml.

Oral CoQ10 supplements are available in the form of oral sprays, tablets, softgel capsules, and hard shell capsules.  

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FAQs: Frequently Asked Questions About Oral CoQ10 Supplements 

Are there side effects to taking a CoQ10 supplement?

CoQ10 supplements are well-tolerated with no adverse side effects. However, its safety in pregnant or nursing women, and children, has not been established.      

Can I take a CoQ10 supplement with a prescription medicine?

It is always recommended to consult with your healthcare provider before incorporating a CoQ10 supplement in your diet or taking it with a prescription medicine.   

How do I determine the efficacy of a CoQ10 supplement?

The efficacy of a CoQ10 supplement lies in enhanced  absorption and bioavailability of the active nutrient molecules. Tesseract’s CoQ10 Pro® is an innovative supplement formulation developed for unparalleled absorption and is in a sustained release format.    

The proprietary CyLoc® - DexKey® nutrient delivery nanotechnology ensures unprecedented absorption of billions of CoQ10 molecules in the intestinal tract, one molecule at a time. The CyLoc® matrix encases each CoQ10 molecule in its smart delivery system, while the DexKey® reactors release each molecule at the desired point in the intestinal tract to achieve maximum absorption. Enhanced absorption enables micro-dosing—the ingestion of a lesser amount of CoQ10 to achieve powerful and positive therapeutic responses to address CoQ10 deficiency symptoms and support optimal health functions.  

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Citations:

1M Alma, et al. Coenzyme Q10: Antioxidants (Basel, Switzerland) 2020;9(4):341. doi:10.3390/antiox9040341
2Mine Y, et al.Journal of clinical biochemistry and nutrition 2022;71(1):29-33. doi:10.3164/jcbn.20-187

TThe power of Tesseract supplements lies in enhancing palatability, maximizing bioavailability and absorption, and micro-dosing multiple nutrients in a single, highly effective capsule. Shop productson our website and learn more about how they can help support cardiovascular health.*

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Article Summary:

If you are considering taking a nutritional supplement for heart health, then CoQ10 and fish oil are the most popular options to choose from. Coenzyme Q10 (or CoQ10) is endogenously produced in the body, and its level is the highest in organs that have high metabolism rates, such as the heart, kidney, and liver. On the other hand, fish oils are derived from the tissues of oily fish, such as tuna, salmon, herring, and mackerel, and contain omega-3 fatty acids known to help support heart health. 

The efficacy, benefits, and drawbacks of CoQ10 and fish oil supplements are much debated, making it difficult to determine the right supplement for your heart health. Below, we compare CoQ10 vs fish oil and explain why you should include a powerful heart health supplement in your diet.

CoQ10 vs Fish Oil: A Comparison

CoQ10, one of the most significant lipid antioxidants, primarily functions as an energy transfer molecule, playing a critical role in the body’s energy production – the Adenosine Triphosphate (ATP) cycle. As an intracellular antioxidant, CoQ10 neutralizes free radicals, preventing them from damaging cellular lipids, proteins, and DNA. The ability of CoQ10 to enhance ATP production and minimize oxidative stress is believed to be the mechanism of action1 that addresses the high metabolic requirements of heart muscles and supports cardiovascular functions.* 

Fish oil primarily contains two types of long-chain omega-3 fatty acids — eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), originally synthesized by microalgae. These microalgae are then consumed by phytoplankton that fish further consume, and the omega-3 fatty acids accumulate in the tissues of the fish. Omega-3 fatty acids play a structural role in cell membranes and are critical to forming eicosanoids, the signaling molecules known to regulate various heart functions.

The following table summarizes the key differences between CoQ10 and fish oil, their benefits, and efficacy to help you determine the right supplement for your heart health. 

CoQ10 vs. Fish Oil: Which One Works Better for You
CoQ10  Fish Oil
Dietary SourcesOily fish, organ meats, cruciferous vegetables, certain fruits, nuts and seeds, and whole grains.Derived from tissues of fatty fish, such as salmon, herring, and tuna.  
Key Benefitsa. Involved in cellular energy production, improves oxygen utilization at the cellular level.*
b. Prevents the generation of free radicals and their adverse impact on cellular structures.*
a. Rich source of omega-3 fatty acids essential for various health functions, including heart, lung, and immune and endocrine systems. 
b. Fish oils with higher DHA content have been found2 to slow the rate of cognitive decline.  
AbsorptionThe absorption of orally ingested CoQ10 is generally poor but varies depending on the formulation.   Fish oil fatty acids are better absorbed in the triacylglycerols form when consumed with a high-fat meal.

Various clinical studies highlight the individual beneficial effects of CoQ10 and fish oil supplements on heart health.* The consumption of CoQ10 and fish oil supplements together has also been found to be therapeutic for heart health.* Further, research3 indicates the potential role of CoQ supplements in enhancing the depleted levels in the body due to the intake of statin medications for regulating cholesterol levels.*  

A Powerful CoQ10 Supplement to Support Your Cardiovascular Health*

It is worth noting that a healthy balanced diet can provide sufficient amounts of CoQ10 to the body. However, oral CoQ10 supplementation might become necessary due to certain pathological conditions or side effects of certain medications. 

One of the significant challenges associated with oral CoQ10 supplementation is CoQ10’s naturally poor absorption and bioavailability, which impacts its efficacy. CoQ10 absorption in the body thus varies widely depending on the supplement formulation. Various strategies have been adopted to enhance the absorption of CoQ10, with CoQ10-loaded nanoparticles displaying the most promising results. 

CoQ10 Pro® developed by Tesseract Medical Research, is a revolutionary CoQ10 nanoformulation utilizing proprietary CyLoc® - DexKey® technology to ensure targeted delivery of the active ingredient molecules at the desired point in the intestinal tract. CoQ10 Pro’s unique formulation enables optimal solubility and maximum absorption of CoQ10 at daily intake levels much lower than previously required. The resulting enhanced efficacy of the formulation supports the optimal functioning of your heart.*

The power of Tesseract supplements lies in enhancing palatability, maximizing bioavailability and absorption, and micro-dosing multiple nutrients in a single, highly effective capsule. Shop products on our website and learn more about how they can help support your cardiovascular health.*

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Citations:

1Raizner AE. Methodist DeBakey cardiovascular journal 2019;15(3):185-191. doi:10.14797/mdcj-15-3-185

2Samaneh GF, et al. 2019;59(11):1684-1727. doi:10.1080/10408398.2018.1425978
3Aaseth Jan, et al 2021;197:111521. doi:10.1016/j.mad.2021.111521

Article Summary:

Coenzyme Q10, or CoQ10, is widely known for its antioxidant properties and is used as a nutritional supplement to inhibit the adverse effects of oxidative stress on vital cellular components.* Although CoQ10 is endogenously produced in the body, the level of CoQ10 decreases with age or due to certain pathological conditions. Depleted levels of CoQ10 can adversely affect various health functions, including the skin.  

As the most voluminous organ of the body, the skin is exposed to external stress factors, including prolonged sun exposure and pollution. The production of free radicals due to oxidative stress triggered by both intrinsic and extrinsic stress factors damages many of the skin’s cellular components. 

Skin cells (cutaneous cells) require a high amount of energy and significant cellular metabolism to resist these harmful effects and regenerate and repair tissues. Low CoQ10 levels are associated with a decline in both cellular energy production and mitochondrial activity, which can impair cellular and tissue functions. This can lead to visible structural alterations of the skin, such as:  

Several studies indicate the beneficial role of CoQ10 in promoting healthy skin and hair.* Below, we discuss Coenzyme Q10’s skin benefits and different CoQ10 supplements available for supporting healthy skin.*      

Coenzyme Q10 Skin Benefits — An Overview

The wide use of Coenzyme Q10 as a nutritional supplement to support optimal skin health, especially the dermis layer, lies in its capacity to enhance cellular energy metabolism and its antioxidant effects.* The following table highlights some Coenzyme Q10 skin benefits established through various research studies.   

Coenzyme Q10 Skin Benefits*
Stimulating collagen production*: Collagen is a necessary protein for maintaining the skin’s elasticity and hydration. A study1 on the effect of CoQ10 on cultured human skin fibroblast** showed that CoQ10 increased the mRNA expression of type I, IV, and VII collagen, along with other critical proteins such as elastin and HSP47.*  **Dermal fibroblasts are the main cell type present in the dermis, the skin connective tissue.
Enhancing cellular metabolism*: An in vivo study2 on keratinocytes — the most dominant cell type in the epidermis, has revealed the positive influence of CoQ10 in enhancing the mitochondrial function of aging skin cells.*  
Mitigating oxidative damage to skin*: Studies3 show that CoQ10 is effective against UVA-mediated oxidative stress in keratinocytes, inhibiting oxidative DNA damage and suppressing the expression of collagenase — the enzyme that breaks down collagen in dermal fibroblasts following UVA radiation.*   
Limiting seasonal deterioration of viscoelasticity: A placebo-controlled study4 on the effects of daily supplementation of CoQ10 on skin parameters showed the intake of CoQ10 limited seasonal deterioration of skin viscoelasticity—the property that results in stability and flexibility of the skin.* 

Although there are multiple CoQ10 skin benefits, the antioxidant molecule in its natural state displays low solubility and poor oral bioavailability, stability, and permeability, which hinders its therapeutic effects. Recently developed supplement formulations have enhanced the absorption and bioavailability of CoQ10 in the body.  

Different Types of CoQ10 Supplements 

Although a balanced diet can provide a sufficient amount of CoQ10, additional supplementation can be required for particular health conditions. Coenzyme Q10 supplements are usually available in soft gel capsules, hard shell capsules, sprays, tablets, and topical creams. The following table briefly discusses these different types of CoQ10 supplements.   

Types of CoQ10 Supplements
Softgel/ Hard Shell CapsulesSprayTabletsTopical cream
Formulated to enhance the bioavailability and absorption of CoQ10.Oral sprays are developed for small, tailored dosages.CoQ10 chewable tablets have enhanced palatability to accomplish patient compliance.The topical application of CoQ10 is shown5 to increase CoQ10 levels on the skin surface.

It is worth noting that the efficacy and benefits of CoQ10 supplementation vary depending on the formulation. Among alternative approaches to enhance CoQ10 absorption, CoQ10 nanoparticles display promising results. 

The CoQ10 Pro® developed by Tesseract Medical Research is a hypoallergenic, solubility-enhanced CoQ10 formulation for optimal absorption and bioavailability. The proprietary CyLoc® - DexKey® nutrient delivery nanotechnology enables targeted active ingredient delivery at the desired point in the intestinal tract for unprecedented absorption. The revolutionary formulation helps keep your skin healthy and protected from the adverse effects of oxidative stress.*

The power of Tesseract supplements lies in enhancing palatability, maximizing bioavailability and absorption, and micro-dosing multiple nutrients in a single, highly effective capsule. Shop products on our website and learn more about how they can help support your cardiovascular health.*

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Citations: 

1Mine Y, et al. Journal of clinical biochemistry and nutrition 2022;77(1):29-33. doi:10.3164/jcbn.20-187

2Prahl S, et al. BioFactors (Oxford, England) 2008;32(1-4):245-55. doi:10.1002/biof.5520320129

3Hoppe U, et al. BioFactors (Oxford, England) 1999;9(2-4)371-378. doi:10.1002/biof.5520090238

4Žmitek K, et al. BioFactors (Oxford, England) 2017;43(1):132-140. doi:10.1002/biof.1316

5Knott A, et al. BioFactors (Oxford, England) 2015;41(6):383-390. doi:10.1002/biof.1239

Article Summary:

Coenzyme Q10 (CoQ10), one of our body's most significant lipid antioxidants, plays a critical role in synthesizing adenosine triphosphate or ATP, better known as the ‘energy currency’ of cells. CoQ10 is abundantly present in the organs that have high metabolism rates, such as the lungs, liver, heart, kidneys, pancreas, spleen, and adrenal glands. CoQ10’s presence in the mitochondrial membrane of the cells prevents the generation of free radicals that can damage cellular proteins, lipids, and DNA. 

Although the body endogenously produces Coenzyme Q10, its level can decrease with age or under certain pathological conditions that result in compromised immunity, poor physical performance, and others. Including Coenzyme Q10-rich foods in your diet and taking a CoQ10 nutritional supplement as an additional source can help maintain this key nutrient’s optimal level in the body. Below we discuss various food sources that are rich in CoQ10 and how a powerful supplement can help keep you healthy, particularly your heart.       

Coenzyme Q10-Rich Foods — An Overview

Coenzyme Q10 naturally occurs in various food sources, with meat, fish, nuts, and olive oil being the richest nutritional sources. Lower amounts of CoQ10 are found in most dairy products, vegetables, cereals, and fruits. It has been observed that diets of different geographical origins vary widely in CoQ10 content. Various clinical trials1 indicate that dietary CoQ10 contributes to the plasma CoQ10 concentration.   

Interestingly, the whole body content of Coenzyme Q10 is only about 500-1,500 mg. Because CoQ10 is a fat-soluble molecule, it is better absorbed in your body when taken with a meal that contains oil or fat. The following table lists Coenzyme Q10-rich foods to include in your diet to enable this nutrient to support various health functions.

Coenzyme Q10 Foods List
Organ Meats Animal organ meats, such as liver and kidney, have the highest amounts of CoQ10. Some muscle meats, such as pork, beef, and chicken, also contain CoQ10.
Fatty Fish Oily fish, including salmon, tuna, trout, mackerel, and herring.
Fruits and Vegetables Strawberries, oranges, broccoli, cauliflower
Nuts and Seeds Peanuts, sesame seeds, and pistachios
Oils Soybean oil and canola oil
Legumes Soybeans, lentils, and whole grains

Notably, the average daily dietary intake of CoQ10 is only 3-6 mg, most of which is in reduced form. Although a diet that includes Coenzyme Q10-rich foods helps produce sufficient CoQ10 in healthy individuals, supplementation might be helpful under certain pathological conditions. 

CoQ10 oral supplements are available in several forms, including oral spray, soft gel capsules, tablets, and hard shell capsules. Supplementing 200 mg2 of CoQ10 daily is recommended to maintain a therapeutic blood level over 2.5 mcg/mL. The clinical effect of taking a CoQ10 supplement is not immediate and might take up to eight weeks to manifest. And although CoQ10 supplements are usually well tolerated, their safety for pregnant or nursing women and children has not been established. 

A significant challenge with the efficacy of CoQ10 supplements is their absorption and bioavailability. CoQ10 has a relatively high molecular weight, is insoluble in water, and has limited solubility in lipids, which can result in it having poor absorption in the gastrointestinal tract. Reduction in CoQ10 particle size (nanoparticles) using cyclodextrin technology is one of the more recent approaches to enhance the absorption and bioavailability of this key antioxidant.

A Powerful CoQ10 Supplement for Your Health 

CoQ10 Pro® is a unique CoQ10 formulation developed by Tesseract Medical Research for advanced absorption. Each capsule of CoQ10 Pro® contains 300 mg of Coenzyme Q10 complex to help support your health, particularly cardiovascular functions.* The proprietary CyLoc® - DexKey® technology ensures optimal solubility of CoQ10 by encasing each active ingredient molecule in a dextrin fiber matrix and transporting them, one at a time, through the intestinal wall. The result is outstanding absorption of CoQ10 in the body, making CoQ10 Pro® superior to oral formulations that feature uncomplexed CoQ10. 

With enhanced absorption and bioavailability of CoQ10 molecules, Tesseract’s CoQ10 Pro® formula enables micro-dosing — the daily intake of the supplement at a level much lower than previously required. The result is a powerful and positive therapeutic response to provide comprehensive cardiovascular support.*

The power of Tesseract supplements lies in enhancing palatability, maximizing bioavailability and absorption, and micro-dosing multiple nutrients in a single, highly effective capsule. Shop products on our website and learn more about how they can help support your cardiovascular health.*

Shop Products

Citations:

1Weber C, et al. ” Molecular Aspects of Medicine 1997;18:S251-254. doi:10.1016/s0098-2997(97)00003-4
2Raizner AE. Methodist DeBakey cardiovascular journal 2019;15(3):185-191. doi:10.14797/mdcj-15-3-185

Article Summary:

You might already be aware of some of the therapeutic benefits of glutathione, such as its mechanism of action in detoxifying your body. As a powerful intracellular antioxidant, glutathione scavenges harmful free radicals, down-regulates oxidative stress, and supports the body’s normal inflammatory response.* Although the body produces and recycles glutathione naturally, the body’s natural level of glutathione becomes depleted with age, making supplementation necessary for maintaining an optimal glutathione level. 

Glutathione nutritional supplements are considered safe, with no severe adverse reactions having been observed in clinical trials.

Glutathione supplements are available in various modes of delivery, including oral, intravenous, topical, intranasal, and nebulized forms. The ease and convenience of oral glutathione supplements usually make it the method of choice. However, given the market’s saturation level,  consumers are flooded with countless options, so determining which oral glutathione supplement is right for you can be challenging.

Below, we discuss how to choose a glutathione supplement that supports natural detoxification pathways in your body and promotes optimal cellular functions.*

Molecular structure of glutathione

How To Choose a Glutathione Supplement: Understanding Poor Absorption

Glutathione is a tripeptide made of three amino acids — cysteine, glutamic acid, and glycine. In the body, glutathione exists in two states — reduced (GSH) and oxidized (GSSG). Let’s first examine how the body absorbs glutathione to understand why it’s known as a conventionally difficult-to-absorb molecule.

Glutathione’s poor absorption and bioavailability in the body mean we should consider several things when choosing a glutathione supplement. The table below summarizes key traits to look for in an effective glutathione supplement to ensure it supports your body's functions.

Choosing A Glutathione Supplement: Factors to Consider
FEATUREFUNCTION
AbsorbabilityS-acetyl-glutathione is the most readily-absorbed and effective form of oral glutathione available. 
PhytonutrientsResearch2 indicates that nutritional interventions, including phytochemicals, minerals, and other phytonutrients, enhance the level of circulating glutathione and translate to therapeutic benefits.
Novel formulationNovel supplement formulations, including nanoformulations, enhance3 the likelihood of glutathione’s water-soluble molecule to cross the water-repelling plasma membrane, thereby enhancing its absorption in the body.

With enhanced bioavailability and absorption, a glutathione supplement promotes detoxification pathways in your body for optimal antioxidant support.*

An Oral Glutathione Supplement With Superior Absorption and Efficacy 

SafeCell® — developed by Tesseract Medical Research — is an innovative oral glutathione supplement formulation designed for superior absorption and efficacy. The supplement contains S-Acetyl-Glutathione, along with plant-derived enzymes, to increase intracellular glutathione levels and down-regulate oxidative stress in the body.* 

To enhance glutathione’s absorption in the body, SafeCell’s formulation is engineered using the patent-pending and revolutionary CyLoc® - DexKey® nanomolecular nutrient delivery technology. A CyLoc® molecular matrix accompanied by a DexKey® release agent enables the nano-delivery of S-Acetyl-Glutathione molecules (one molecule at a time) for optimal absorption. The Tesseract Effect® transcends glutathione’s common absorption issues to maximize its therapeutic benefits as a master antioxidant and detoxifying agent.* The result is successful detoxification achieved at a level other glutathione supplements struggle to match.*

The power of Tesseract supplements lies in enhancing palatability, maximizing bioavailability and absorption, and micro-dosing multiple nutrients in a single, highly effective capsule. Shop products on our website and learn more about how they can help support your hepatic health.*

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Citations

1Tateishi N, et al. The Journal of Nutrition vol. 107,1 (1977): 51-60. doi:10.1093/jn/107.1.51

2Minich DM, Brown BI. Nutrients vol. 11,9 2073. 3 Sep. 2019, doi:10.3390/nu11092073

3Bruggeman BK, et al.  PloS one vol. 14,4 e0215815. 30 Apr. 2019, doi:10.1371/journal.pone.0215815

Your skin is the largest organ in your body and needs high-quality nutritional support for optimal functioning. Quercetin, a natural antioxidant, helps protect your skin's health from damage caused by pollution, UV radiation, and other environmental stressors.* 

Get the answers to common queries about this wondrous molecule, including how it offers therapeutic benefits for your skin and the best way to include it in your diet. Use the links below to jump ahead to different topics on the page.

What Is Quercetin and Where Is It Found? Potential Therapeutic Applications
How Does Quercetin Support Skin Health? Does Oral Ingestion Help?
Factors Affecting Quercetin Absorption Strategies To Enhance Bioavailability
The Most Bioavailable Form of Quercetin Why Do You Need Quercetin Supplements?
Different Types of Quercetin Supplements FAQs: Frequently Asked Questions

What Is Quercetin and Where Is It Found?

Quercetin is a naturally occurring phytochemical, or flavonoid compound, found in fruits and vegetables. Quercetin and its derivatives have antioxidant properties that help regulate the body's natural inflammatory response, translating to powerful positive bioactive effects on cell cycle progression and cellular signaling pathways.* 

Quercetin, mainly Quercetin-3-O-glycoside, primarily serves as a pigment in fruits, vegetables, and flowers. Some key dietary sources of quercetin include apples, grapes, berries, cherries, citrus fruits, cruciferous vegetables, onion, kale, buckwheat, tomatoes, red wine, and black tea. It is worth noting that quercetin concentrations can vary from one plant to another or even in different parts of the same plant. Onions, tea, and apples contain significantly higher amounts of quercetin.

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Potential Therapeutic Applications of Quercetin 

Flavonoids like quercetin are considered more powerful antioxidants than vitamins C and E. As an antioxidant that supports the body's natural inflammatory responses, quercetin extends therapeutic effects mainly by inhibiting kinases, oxidative damage, and cell cycle growth and supporting neuronal survival.* The following table lists some potential therapeutic applications for quercetin in the human body.*

System Therapeutic Applications
Cardiovascular Health*
Kidney Health*
Immune Function*
Gastrointestinal Health*
Brain Health*


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How Does Quercetin Support Skin Health? 

Evidence1 suggests that oxidative stress caused by reactive oxygen and nitrogen plays a critical role in the development of various skin disorders. The molecular features of quercetin make it a potent scavenger of reactive oxygen species (ROS) and reactive nitrogen species (RNS).* Quercetin's ability to quench free radicals and support the cutaneous antioxidant defense system makes it a preferred choice for extensive skin care and therapeutic applications.*

In helping to maintain the body’s normal natural inflammatory responses, quercetin has been found2 to inhibit the release of histamine---a critical compound for immune responses---from basophils and mast cells.* Quercetin can also inhibit the release of the proinflammatory cytokines and interleukin-4 (IL-4) and IL-13, the signaling molecules secreted by immune cells to trigger inflammatory responses.*

The potential benefits quercetin offers for skin health can be condensed into two main functions: protection and restoration.*   

Quercetin’s Skin Benefits*
Protection*Restoration*
Quercetin enhances protection from skin damage caused by factors like UV radiation, toxic chemical contact, and histamines.*Quercetin can help restore the skin’s barrier by supporting hydration and limiting transepidermal water loss (TEWL)* — the less water the skin passively evaporates, the higher its integrity levels.    
Studies3 show that quercetin can enhance protection against UV-mediated skin damage by directly inhibiting activities of protein kinase C delta (PKCδ) and Janus kinase 2 (JAK2), two key components of intracellular cell signaling pathways.*Lipids in the outermost epidermal layer are vital to maintaining the skin's permeability barrier. When peroxidated, these lipids produce toxic effects in skin cells. Studies4 suggest quercetin’s role in reducing lipid peroxidation helps restore barrier functions to damaged skin.*   

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Does Oral Ingestion of Quercetin Help?

Although quercetin can be obtained in the diet from various fruits and vegetables, it is poorly absorbed in the body. 

Studies5 show that only one percent of quercetin is absorbed when it is ingested orally.   

Quercetin’s low absorption, extensive metabolism, and rapid elimination from the body contribute to its low bioavailability from nutritional supplements.   

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Factors Affecting Quercetin Absorption in the Body

Quercetin is primarily absorbed in the upper segment of the small intestine. Post-absorption, the flavonoid is metabolized in various organs, including the liver, small intestine, colon, and kidney, with the help of biotransformation enzymes specific to the liver and small intestine. Finally, the kidney excretes quercetin and its metabolites in the urine.

The key factors affecting quercetin’s absorption in the body are:

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Strategies to Enhance the Absorption of Quercetin

Some conventional approaches have been to enhance quercetin absorption, such as intake of the better-absorbed glycosylated form of quercetin, consumption of sources with higher quercetin content, or consuming quercetin with dietary components.   

The ideal strategy for enhancing quercetin’s bioavailability is to protect its integrity in the upper gastrointestinal tract and release it in the colon with prolonged sustained release.

Novel Formulations

Alternative delivery systems, including nanoformulations, can help overcome bioavailability-related issues in quercetin supplements. Nutraceuticals formulated at the nanoparticle level achieve a larger surface area compared to their typical raw material counterparts.  They can be customized for targeted delivery of quercetin molecules while protecting their integrity against enzymes and other physiological conditions. Nanoparticles also enable a controlled release of quercetin molecules at the desired point in the intestinal tract.  

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The Most Bioavailable Form of Quercetin

Different forms of Quercetin

Image Resource 

It is worth noting that the solubility of different forms of quercetin varies. Quercetin aglycones or glycosides in apples, tea, or red wine have lower solubility compared to quercetin glucoside from onions, which appear to have the highest absorption rate.

Quercetin glucoside — the naturally occurring form of quercetin — displays7 an estimated absorption rate of 3%-17% per 100 mg of ingested quercetin.

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Why Do You Need A Quercetin Supplement?

With its low water solubility, unformulated quercetin ranks low in terms of therapeutic benefits. Although dietary sources do support your body with lower concentrations of quercetin, consuming a higher concentration can require a nutritional supplement. Strategies like structural transformation, absorption enhancers, carrier complexes, and nanotechnology help develop highly bioavailable quercetin supplement formulations for benefits including:

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Different Types of Quercetin Supplements

Various forms of quercetin supplements offer multiple delivery modes, including:

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FAQs: Frequently Asked Questions About Oral Quercetin Supplements 

Are there side effects to taking a quercetin supplement?

Quercetin intake as a dietary supplement at one gram daily3 is considered safe; adverse side effects from quercetin supplementation have rarely been reported. However, the clinical results of long-term quercetin use at levels at or above one gram daily for longer than 12 weeks are yet to be determined.

Can I take a quercetin supplement with a prescription medicine?

It is always recommended that you consult with your health-care provider before including a quercetin nutritional supplement in your diet or taking one along with a prescription medicine.  

How do I determine the efficacy of a quercetin supplement formulation?

The efficacy of a quercetin supplement formulation lies in enhanced bioavailability and absorption of the active nutrient molecules. Tesseract’s QuerciSorb Immuphore SR®, an innovative quercetin supplement complex, contains four ingredients — quercetin, zinc, vitamin C, and vitamin D — to support the immune system’s optimal functioning, which includes healthy skin.*

The proprietary CyLoc® - DexKey® technology is a revolutionary nanomolecular nutrient delivery system that enhances the absorption of quercetin molecules by releasing them at the desired point in the intestinal tract. The unprecedented levels of absorption and bioavailability in each quercetin molecule enable micro-dosing of this formulation to support immune function all day long.*

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Citations:

The power of Tesseract supplements lies in enhancing palatability, maximizing bioavailability and absorption, and micro-dosing multiple nutrients in a single, highly effective capsule. Shop productson our website and learn more about how they can help support immune health.*

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1Byamba D, et al. Annals of Dermatology vol. 22,3 (2010): 269-278. doi:10.5021/ad.2010.22.3.269

2Weng Z, et al. PloS One vol. 7,3 (2012): e33805. doi:10.1371/journal.pone.0033805

3Shin, EJ, et al. International Journal of Molecular Sciences vol. 20,21 5262. 23 Oct. 2019, doi:10.3390/ijms20215262

4Maramaldi , et al. Clinical, Cosmetic and Investigational Dermatology vol. 9 55-62. 26 Feb. 2016, doi:10.2147/CCID.S98890

5Gugler R, et al. European Journal of Clinical Pharmacology vol. 9,2-3 (1975): 229-234. doi:10.1007/BF00614022

6Guo Y, et al. Molecular Nutrition & Food Research vol. 57,5 (2013): 896-905. doi:10.1002/mnfr.201200619

7Li Y, et al. Nutrients vol. 8,3 167. 15 Mar. 2016, doi:10.3390/nu8030167

Article Summary:

Flavonoids are a class of phytonutrients found naturally in various fruits and vegetables and are known to help the body fight off free radicals. Lately, there has been a growing scientific interest in examining how flavonoids influence multiple biological pathways and immune functions. As a flavonoid, quercetin is well known for its antioxidant activities in scavenging free radicals and supporting the body’s natural inflammatory response.* Natural sources of quercetin include berries, grapes, apples, cruciferous vegetables, onions, shallots, tomatoes, tea, and other plant products.

Below, we discuss how your body could benefit from quercetin’s immune support properties and why you should consider incorporating this antioxidant into your diet in nutritional supplement form.

How Do Quercetin’s Immune Support Properties Work?

Quercetin's various forms include methylated quercetin, quercetin sulfate, quercetin glucuronide, and quercetin glycoside. Specific properties of the glycoside group enhance quercetin's water solubility, making it more absorbable than other forms. As an antioxidant, quercetin’s beneficial effects on the body’s immunomodulatory pathways increase its potential for immune function support.* Let’s take a closer look at how quercetin’s immune support properties work. 

Quercetin’s Immune Function Support Properties
Antioxidant Effects*Immunomodulatory Effects*
Quercetin’s molecular structure is credited1 with its higher efficiency in scavenging free radicals.*  Quercetin mainly confers3 immune support by up-regulating the activity of leukocytes — the body’s natural defense against invading organisms.* Quercetin also exerts its immuno-supportive activity by benefiting intracellular signaling pathways, enzymes, and membrane proteins.*
As a potent lipid oxidation inhibitor, quercetin helps suppress the start of chain oxidation and propagation of free radicals.*Research studies4 show that quercetin’s role in stabilizing mast cells and gastrointestinal cytoprotective activities benefits immune function.*   
Quercetin’s endogenous antioxidant properties modify2 a range of cellular injury by free radicals.* Studies find5 quercetin influences dendritic cell functions — initiator and master regulator of antigen-specific immune responses.*  

Various studies indicate quercetin is primarily absorbed in the upper segment of the small intestine and later metabolized in multiple organs, including the liver, small intestine, colon, and kidney. However, quercetin is known for its poor oral bioavailability. Only 3% to 17% of quercetin glucoside — the most absorbable form — gets absorbed in healthy individuals after ingesting 100 mg. Although onions are known to be the highest natural source of quercetin, clinical trials show that after consuming an onion-rich meal, quercetin values peaked from baseline values after 2 hours, only to decrease to baseline again after 24 hours.

Zinc enhances quercetin's therapeutic benefits on several enzymes involved in the body’s immune responses.* Quercetin also acts as an ionophore for zinc — creating channels in cell membranes to enhance intracellular zinc concentration.* Promising evidence suggests a synergistic protective effect of a quercetin, zinc, and vitamin C complex in benefiting the body’s natural immune responses.*       

A Quercetin Supplement to Support Your Immune Function

QuerciSorb® Immuphore SR is an innovative supplement formulated with a soluble form of quercetin to support healthy immune function.* Developed by Tesseract Medical Research, the supplement contains other bioactive ingredients, including zinc, vitamin C, and vitamin D, to support the immune system's optimal functioning.*

Tesseract's proprietary CyLoc - DexKey® nutrient delivery technology enables the ground-breaking delivery of quercetin molecules through the gut wall, one molecule at a time, for unprecedented quercetin absorption in the body. The CyLoc® technology encases each quercetin molecule to maintain its integrity during transit through the stomach. The DexKey® technology accompanies each CyLoc® molecule to release the active ingredient molecule at the desired point within the gastrointestinal tract. The result is maximum absorption and effectiveness for each quercetin molecule, making it a bioavailable therapeutic reality to support immune function.* 

The power of Tesseract supplements lies in enhancing palatability, maximizing bioavailability and absorption, and micro-dosing multiple nutrients in a single, highly effective capsule. Shop products on our website and learn more about how they can help support immune health.*

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Citations:

1Rice-Evans CA, et al. Free Radical Research vol. 22,4 (1995): 375-383. doi:10.3109/10715769509145649

2Mlcek J, et al. Molecules (Basel, Switzerland) vol. 21,5 623. 12 May. 2016, doi:10.3390/molecules21050623

3,4Chirumbolo S. Inflammation & Allergy Drug Targets vol. 9,4 (2010): 263-285. doi:10.2174/187152810793358741

5Huang RY, et al. Journal of Immunology (Baltimore, Md.:1950) vol. 184,12 (2010): 6815-6821. doi:10.4049/jimmunol.0903991

6McAnlis GT, et al. European Journal of Clinical Nutrition vol. 53,2 (1999): 92-96. doi:10.1038/sj.ejcn.1600682
7Sahib HB, et al. Advances in Virology vol. 2022 1575605. 8 Jun. 2022, doi:10.1155/2022/1575605

Article Summary:

Glutathione, a powerful antioxidant found in almost every cell of the body, supports a wide range of health functions.* A tripeptide compound of three amino acids — cysteine, glutamic acid, and glycine — glutathione acts primarily as a detoxifying agent, efficiently scavenging different types of free radicals.* Glutathione’s antioxidant properties have prompted researchers to turn  increasing levels of attention toward investigating glutathione for its potential role in promoting skin health and supporting optimal hair health.*

Below, we discuss some of glutathione’s benefits for hair growth and explain why you should include a glutathione nutritional supplement in your diet to promote healthy hair growth.*   

How Does Glutathione Promote Healthy Hair?

Reactive oxygen species (ROS) — or free radicals — cause damage to key cellular components like DNA, RNA, lipids, proteins, and structural membranes. As a key part of the body’s endogenous defense mechanism, the presence of glutathione neutralizes and reduces these free radicals.*

The production of ROS increases with age, at the same time our internal defense mechanisms weaken, resulting in oxidative stress — an imbalance where ROS outnumber antioxidants in the body. It is widely presumed that progressive damage to cellular structures from oxidative stress is a key factor in the appearance of aging. In hair, this evidence of aging includes:  

Circumstantial evidence2 suggests oxidative stress is the key factor behind graying hair and hair loss. Because glutathione’s primary function is down-regulating oxidative stress, supplementing your diet with glutathione-rich food sources is associated with supporting hair health. The following table summarizes how glutathione can play a role in delaying signs of aging in hair.*

How Glutathione Supports Hair Health*
RESULTSDETAILS
Levels linked to
hair color
An animal study3 links the degree of hair melanization (pigmentation) to glutathione levels. The enzymes that indirectly affect melanogenesis are glutathione reductase and glutathione peroxidase.  
Prevents hydrogen peroxide damageResearch shows4 how white scalp hair shafts accumulate hydrogen peroxide in minuscule concentrations. The oxidative damage to hair follicles by hydrogen peroxide is linked to senile hair graying. Various studies5 have established the role of glutathione peroxidase as a key enzyme in hydrogen peroxide removal.  

As aging depletes the body’s endogenous levels of glutathione, additional oral intake of glutathione in the form of food and nutritional supplements can help maintain glutathione’s optimal production and recycling to support various body functions.*     

Achieving Glutathione Benefits for Hair With A Nutritional Supplement 

A major challenge with the oral intake of glutathione is its rapid degradation in the stomach, which significantly limits its absorption and bioavailability. Poor absorption in the body means only a small amount of glutathione reaches the cells where it is needed most, thereby limiting its potential therapeutic effects. 

SafeCell® — an acetylated form of glutathione developed by Tesseract Medical Research, transcends these common absorption issues. SafeCell’s innovative supplement formulation contains S-Acetyl-glutathione, the most readily absorbed and effective form of oral glutathione available.* Tesseract’s unprecedented CyLoc® - DexKey® nutrient delivery technology provides targeted nano-delivery of S-Acetyl-glutathione molecules at the cellular level, one molecule at a time. This unprecedented bioavailability and absorption of glutathione support the body’s natural detoxification pathways and promote optimal hair health.

The power of Tesseract supplements lies in enhancing palatability, maximizing bioavailability and absorption, and micro-dosing multiple nutrients in a single, highly effective capsule. Shop products on our website and learn more about how they can help support healthy aging.*

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Citations

1Trüeb RM. Experimental Gerontology vol. 37,8-9 (2002): 981-990. doi:10.1016/s0531-5565(02)00093-1

2Harman D. Journal of Gerontology vol. 11,3 (1956): 298-300. doi:10.1093/geronj/11.3.298

3Galván I, et al. Physiological and Biochemical Zoology: PBZ vol. 85,4 (2012): 332-347. doi:10.1086/666606

4Wood JM, et al. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology vol. 23,7 (2009): 2065-2075. doi:10.1096/fj.08-125435
5Ng CF, et al. Free Radical Research vol. 41,11 (2007): 1201-1211. doi:10.1080/10715760701625075

Article Summary:

Studies demonstrate that anandamide, a neurotransmitter that binds to the cannabinoid receptors in the brain and elsewhere in the body, bestows an overall up-regulating effect on the brain’s reward circuitry.* Dopamine — another brain neurotransmitter — is well-known for modulating excitatory and inhibitory neurotransmissions between brain cells that control emotions, memory, movement, and reward. Lately, the close relationship between these two neurotransmitters and their role in inducing a sense of happiness has received significant scientific interest, owing to the immense potential for their application in adverse health and nutritional conditions.

Below, we discuss how anandamide and dopamine function together to support mental well-being* and how to enhance your body’s anandamide level with a nutritional supplement.        

How Do Anandamide and Dopamine Work Together?

Before understanding how anandamide and dopamine are related, let’s look at the separate roles each one plays in influencing our moods. 

Dopamine

In addition to being known as the “happy” or “feel-good” hormone, dopamine also functions as a neurotransmitter that carries messages between nerve cells. Although a low level of dopamine is related to certain neurodegenerative conditions in the body, a high level of dopamine can also be detrimental to cognitive functioning. An optimal level of dopamine falls somewhere between the two extremes at a median, or “Goldilocks” level — where everything is “just right.”

Anandamide

Synthesized in the brain by neurons, as well as in the body’s peripheral tissues, to modulate mood and memory, anandamide is a critical component of the endocannabinoid system (ECS). Anandamide binds to and activates cannabinoid Type I (CB1) receptors and acts as a messenger molecule for responses to general stress and occasional anxiety (not Generalized Anxiety Disorder).* 

The body’s natural production of anandamide can decrease because of certain undesirable health conditions, and its degradation can be exacerbated by excessive activity from the fatty acid amide hydrolase (FAAH) enzyme. Such reduced anandamide levels can compromise the body’s natural adaptive responses to stress- and anxiety-filled environments.

The endocannabinoid system, and anandamide in particular, is known to modulate dopamine activity via inhibitory and excitatory synapses, the minute gaps between nerve cells that carry messages along neurotransmitters, although the specific cellular mechanisms that produce these mitigating effects remain unknown. The table below summarizes the interrelated functions of anandamide and dopamine and how anandamide influences optimal dopamine levels in the body.  

Anandamide and Dopamine: Interrelated Functions
FUNCTIONS  FINDINGS
Anandamide influences dopamine transmission*Findings1 show anandamide modulates activity of dopamine transporter (DAT) — a protein that controls dopamine transmission*   
Anandamide can increase extracellular dopamine levels*When anandamide is injected intravenously in alert, free-moving rats2, it increases extracellular dopamine levels 
Anandamide can interact with the dopaminergic system* to trigger the brain’s neural circuits* * The dopaminergic system involves the synthesis and secretion of dopamine. An animal study3 showed anandamide release increased eight times above baseline levels after introducing a dopamine receptor agonist — a chemical that binds to or blocks certain receptors 

Many other studies have established anandamide's role in beneficially influencing dopamine levels. Furthermore, the activation of dopamine D2-autoreceptors — which are key components in dopamine synthesis, release, and uptake — has been found4 to enhance the body’s anandamide concentrations by increasing synthesis and diminishing degradation.* Given such deeply interrelated functions and the combined effects of anandamide and dopamine on a wide range of brain activities,* it is critical to maintain an optimal level of anandamide production in the body.

Supporting Anandamide Production With a Nutritional Supplement

Although the body naturally produces anandamide, certain adverse health conditions can inhibit its synthesis and release. Also, excessive activity of the fatty acid amide hydrolase (FAAH) enzyme can further aggravate the degradation of anandamide, resulting in compromised neurological functions. 

A healthy lifestyle and a well-balanced diet containing anandamide-rich foods support an optimal level of anandamide production in the body. In addition, an anandamide nutritional supplement can help fill the gaps in your diet. 

Developed by Tesseract Medical Research, AnaQuell® is an innovative supplement formulation containing anandamide and L-citrulline to support a healthy response to mild anxiety (not GAD), stress, mood changes, and trauma. Enhanced by Tesseract’s proprietary CyLoc® - DexKey® nutrient delivery technology, AnaQuell is designed for the unprecedented absorption and bioavailability of anandamide and citrulline in the body to promote optimal neurological health.*

The power of Tesseract supplements lies in enhancing palatability, maximizing bioavailability and absorption, and micro-dosing multiple nutrients in a single, highly effective capsule. Shop products on our website and learn more about how they can help support neurological health.*

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Citations:

1Oz M, et al. Journal of Neurochemistry vol. 112,6 (2010): 1454-1464. doi:10.1111/j.1471-4159.2009.06557.x

2Solinas M, et al. Journal of Neurochemistry vol. 98,2 (2006): 408-419. doi:10.1111/j.1471-4159.2006.03880.x

3Giuffrida A, et al. Nature Neuroscience vol. 2,4 (1999): 358-363. doi:10.1038/7268
4Centonze D, et al. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology vol. 29,8 (2004): 1488-1497. doi:10.1038/sj.npp.1300458

Article Summary:

It might not seem obvious, but the foods you eat can affect your brain health to a great extent. Several studies1 show a correlation between brain function and overall diet composition, including specific dietary components like anandamide. 

Chemically, anandamide is a naturally occurring derivative of arachidonic acid that can stimulate a sense of happiness and mental well-being.* Including this ‘bliss molecule’ in your diet can promote and optimize a wide range of health functions, including memory, sleep, appetite, and healthy responses to mood changes and stress.*

Below, we discuss several anandamide-rich foods that can naturally support brain function and how an anandamide supplement can help fill in nutritional gaps in your diet.   

Anandamide-Rich Foods to Include in Your Diet 

Anandamide is an endocannabinoid, a lipid-based neurotransmitter produced inside the body. When you include food sources that contain anandamide in your diet, you stimulate its natural production. Some food sources, like cocoa beans and truffles, contain anandamide, while other foods contain compounds that act as anandamide precursors to increase this endocannabinoid’s activity or level in the body.     

The following table lists food sources for natural support of your body’s anandamide production. 

Anandamide-Rich Foods that Support Brain Function
Vegetables
and fruits
Vegetables and fruits contain kaempferol — a flavonoid that inhibits the action of the enzyme fatty acid amide hydrolase (FAAH), which can delay the enzyme’s breakdown of anandamide. 
Cruciferous, yellow, and green leafy vegetables, such as kale, cabbage, green beans, cucumber, squash, tomatoes, broccoli, and Brussels sprouts. 
Fruits such as berries (gooseberries, blackberries, raspberries, strawberries), apples, grapes, citrus fruits, peaches, and grapefruit.
ProteinsMeat, fish, seafood, and eggs are rich sources of arachidonic acid — an essential polyunsaturated fatty acid responsible for generating anandamide naturally.   
Spices
and herbs
Black pepper and long pepper contain guineensine — a novel plant compound  that inhibits the cellular uptake of anandamide. Herbs like dill, chives, saffron, and tarragon contain kaempferol that inhibits FAAH activity.
BeveragesBeverages like tea — particularly green and black Kenyan tea — also contain kaempferol. 
ChocolateThe mood-boosting effects of chocolate are attributed2 to cacao beans or nibs, which contain various beneficial compounds, including anandamide. The less processed the chocolate (without sugar) you consume, the more beneficial its effects will be.
TrufflesStudies find3 these underground mushrooms contain endocannabinoid metabolic enzymes, as well as anandamide. 

In addition to these food sources, a nutritional supplement that contains anandamide can also help stimulate its production in your body to support your mental well-being.*  

Optimize Your Brain Health With a Potent Anandamide Supplement* 

Anandamide’s positive influence on various brain activities, including memory, sleep, appetite, and others, has been studied4 extensively.* The amino acid L-citrulline is a precursor of L-arginine, a key component in the production of nitric oxide (NO), which is known for relaxing blood vessels and enhancing blood supply to the brain, thereby playing a role in inducing neuronal activities. Tesseract Medical Research has developed AnaQuell® — a powerful supplement formulation that takes advantage of the therapeutic benefits of both anandamide and L-citrulline to promote a healthy response to mild anxiety (not General Anxiety Disorder), mood changes, stress, and trauma.*   

To further enhance the body’s absorption of anandamide, the AnaQuell formulation utilizes Tesseract’s revolutionary CyLoc® - DexKey® nutrient delivery system, leading to more positive therapeutic outcomes. CyLoc® technology encases individual molecules of the active ingredient in a dextrin fiber delivery cage to maintain its integrity during transit through the gastrointestinal (GI) tract. Tesseract’s DexKey® technology enables the targeted delivery of billions of active ingredient molecules - one molecule at a time, at the desired release point in the GI tract for maximum absorption. This optimal delivery capability enables micro-dosing of the active ingredients in a single capsule, resulting in a powerful physiological response. 

AnaQuell®’s innovative formula is available in a sustained release (SR) format, for prolonged support of your mental and emotional well-being.*

The power of Tesseract supplements lies in enhancing palatability, maximizing bioavailability and absorption, and micro-dosing multiple nutrients in a single, highly effective capsule. Shop products on our website and learn more about how they can help support neurological health.*

Shop Products

Citations

1Ekstrand B, et al. Nutrition Reviews vol. 79,6 (2021): 693-708. doi:10.1093/nutrit/nuaa091

2Nehlig A. British Journal of Clinical Pharmacology vol. 75,3 (2013): 716-727. doi:10.1111/j.1365-2125.2012.04378.x

3Pacioni G, et al. Phytochemistry vol. 110 (2015): 104-110. doi:10.1016/j.phytochem.2014.11.012

4Scherma M, et al. Acta Pharmacologica Sinica vol. 40,3 (2019): 309-323. doi:10.1038/s41401-018-0075-x

The advanced formulations based on our revolutionary, patented, and patent-pending technology are only available through Tesseract. No other medical, pharmaceutical, or supplement company is licensed to utilize our proprietary technology.
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
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