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Glutathione for Brain Health Support: Exploring Support Possibilities

Updated on April 24, 2025

Article Summary:

  • Glutathione limits oxidative stress, an underlying cause of decline in cognitive function.*
  • Various studies highlight the role of glutathione in maintaining normal cognitive function and promoting neurological health.*
  • Glutathione’s low absorption and bioavailability hinder its efficacy as a nutritional supplement. 
  • Tesseract’s proprietary nutrient delivery nanotechnology enables optimal solubility of the ‘master antioxidant’ to help achieve its health-promoting benefits.  

Oxidative stress is an underlying cause of age-related cognitive function decline. It slowly builds up as a result of the aging process, exposure to chemical stressors, parasympathetic nervous system activation, and unrepaired stress damage. Antioxidants that help the brain cope with oxidative stress, such as glutathione, are, therefore, excellent candidates for helping to maintain cognitive function.*  

Because the level of glutathione depletes with aging, cognitive functions can be adversely impacted. Glutathione is involved in various metabolic processes, including regulating cellular division and differentiation, detoxification, immune cell function, and scavenging circulating reactive oxygen species (ROS).* Glutathione directly interferes with the oxidation of cellular proteins and limits oxidative stress.* Owing to the close relationship between cognitive function and oxidative stress, glutathione is a well-indicated candidate for helping to maintain cognitive function during aging.*   

This article explains the benefits of glutathione for brain health and how Tesseract’s glutathione formulation enables optimal absorption and bioavailability of the body’s ‘master antioxidant’.  

Exploring Glutathione for Brain Health

Extensive research has studied the role of glutathione in brain health. The following table highlights studies that have established the beneficial correlation between glutathione and neurological health.*

Glutathione for Brain Health*
  • Lower glutathione level and mild cognitive impairment: In a study assaying glutathione concentrations in the blood of individuals with mild cognitive impairment, all 25 participants with mild cognitive impairment had markedly lower glutathione levels than the study’s 53 control participants.1
  • Location and oxidation state of glutathione and mild cognitive impairment: A study found that increased ratios of oxidized glutathione to its unoxidized state in the anterior and cingulate cortices of the brain were associated with symptoms of mild losses of cognitive function.* Participants in the study who were diagnosed with mild cognitive impairment had 2.2 to 2.9 times as much oxidized glutathione in their brain as the healthy controls.2

    A high concentration of oxidized glutathione in the brain can mean there is insufficient glutathione to remove the ROS that are circulating, indicating significant levels of cellular stress.
  • Glutathione supplementation to maintain normal cognitive function: Researchers studied whether glutathione infusion could rescue cells that had been artificially stressed by ROS and various other toxins in vitro. When glutathione molecules were infused into neurons exhibiting high levels of neuronal stress, their concentration of signaling molecules associated with cellular stress was reduced by 50 percent.3

    This finding suggests that glutathione supplementation could be a viable option for helping to maintain normal cognitive function.*

Although glutathione supplementation presents a potentially promising method of maintaining healthy cognitive function, the compound is aggressively and rapidly metabolized by the liver, and dietary glutathione rarely makes it into the bloodstream to capture ROS. Highly bioavailable glutathione supplements contained in sophisticated delivery systems can traffic the molecule through the first pass of metabolism to increase its bioavailability.  

The Potential of Glutathione Supplementation

The most modern nutrient delivery systems incorporate nanotechnology that encapsulates glutathione in a sphere of fat molecules. After surviving first-pass metabolism, the glutathione supplement needs to find a way to cross the blood-brain barrier so it can scavenge ROS and benefit cognitive function.*

With the right glutathione supplement, the brain’s concentrations of glutathione can be sufficient to help maintain healthy cognitive function.* SafeCell®, developed by Tesseract Medical Research, is an innovative glutathione supplement that solves glutathione’s bioavailability and absorption challenges. 

SafeCell’s acetylated glutathione formula utilizes Tesseract’s proprietary CyLoc® – DexKey® nutrient delivery technology to achieve the benefits of glutathione for brain health.* The CyLoc® technology encases glutathione molecules for safe passage through the stomach, and the accompanying Dextrin® reactors release the active glutathione molecules at the desired point in the gastrointestinal tract to achieve their optimal absorption. 

The power of Tesseract’s nutritional supplements lies in enhancing palatability, maximizing solubility, absorption and bioavailability, and micro-dosing multiple nutrients in a single, highly effective capsule. Visit our website for more information about how Tesseract’s products support your neurological health .*

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References: 

1Rinaldi P, et al. Neurobiology of Aging vol. 24,7 (2003):91591-9. doi:10.1016/s0197-4580(03)00031-9

2Duffy SL, et al. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association vol. 10,1 (2014):67-75. doi:10.1016/j.jalz.2013.01.005

3Lee M, et al. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology vol. 24,7 (2010):2533-2545. doi:10.1096/fj.09-149997

Al Czap, Founder | Tesseract

Al Czap has more than four decades of professional experience in preventative medicine. He founded Thorne Research in 1984 (sold in 2010) and he published Alternative Medicine Review for 17 years beginning in 1996. AMR was a highly acclaimed, peer-reviewed, and indexed medical journal. Al was the first to recognize the need for hypoallergenic ingredients and to devise methods of manufacture for and delivery of hypoallergenic products to underserved patient populations. His work has greatly impacted those with impaired immune and digestive systems and compromised health due to environmental exposures.

The advanced formulations based on our revolutionary, patented, and patent-pending technology are only available through Tesseract. No other medical, pharmaceutical, or supplement company is licensed to utilize our proprietary technology.
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
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