Article Summary:

• As a critical component of the body’s endocannabinoid system (ECS), anandamide plays a central role in supporting various physiological functions, including mood, appetite, learning, and memory.*
  
• An adequate anandamide level can usually be maintained through a healthy diet, and exercise, but may benefit from regular use of a nutritional supplement.  
  
• Tesseract’s AnaQuell^TM is an innovative anandamide supplement that utilizes proprietary nutrient delivery nanotechnology to enable unprecedented absorption of the active nutrient to promote optimal neurological health.*

Have you heard of the ‘bliss molecule,’ anandamide, that helps regulate our emotional and mental well-being?* Scientific literature indicates the potential role of anandamide in regulating the brain’s reward circuitry and how it supports neurological health¹.* But how does anandamide interact with the brain to exert its therapeutic benefits? 

Although the mechanisms of action of endocannabinoids, including anandamide, are not fully understood, research highlights the benefits of anandamide in maintaining the body’s internal state of balance called homeostasis.* This article explains how anandamide positively influences brain function and why you should include an advanced anandamide supplement in your diet.*     

What Does Anandamide Do to the Brain — An Overview 

The body’s endocannabinoid system (ECS) includes cannabinoid receptors (CB₁ and CB₂), endocannabinoids (anandamide and 2-AG), and enzymes (fatty acid amide hydrolase (FAAH) and monoacylglycerol acid lipase (MGL)). Anandamide primarily binds to and activates CB₁ receptors across different body and brain regions. The FAAH enzyme breaks down anandamide into ethanolamine and arachidonic acid. 

Research demonstrates the correlation between the levels of ethanolamine phosphate in the blood and mental health². Arachidonic acid is a polyunsaturated fatty acid in the brain, and its elevated level is associated with mood disorders³. 

The following table summarizes how anandamide supports a healthy response to mood changes and helps maintain mental and emotional well-being.*   

How does Anandamide Influence Brain Functions?
Regulating mood*	Anandamide regulates emotional responses to stress and influences the activities of key hormones — dopamine, oxytocin, serotonin, and endorphins.* These hormones, in turn, are responsible for feel-good emotions and sensations.
Stimulating appetite*	Anandamide stimulates CB1 receptors to induce appetite, influencing eating behavior and food intake.*
Learning and Memory*	The ECS regulates learning and memory processes through fine-tuned neural transmission. In animal studies, anandamide displays enhanced learning and memory processes in the hippocampus* — a complex structure in the brain’s temporal lobe4.
Sleep Induction*	Clinical studies indicate that anandamide enhances adenosine levels, a sleep-inducing molecule in the brain5.

Although the body produces anandamide, specific conditions such as an excessive activity of the FAAH enzyme can enhance anandamide degradation, resulting in lower levels. A depleted anandamide level can disrupt homeostasis, resulting in various adverse effects, including improper regulation of sleep, mood, and appetite.* 

Including An Anandamide Supplement in Your Diet

Different approaches to enhancing the level of anandamide in the body include diet, active lifestyle, and nutritional supplements. 

• Healthy Diet and Exercise: A diet of chocolates, truffles, long pepper, black pepper, virgin olive oil, fatty fish, walnuts, and eggs can increase endogenous anandamide production. An active lifestyle with endurance exercises provides a ‘runner’s high,’ indicating an enhanced expression of CB₁ cannabinoid receptors and endocannabinoids like anandamide. 

• Nutritional Supplements: Another alternative is including an advanced nutritional supplement to maintain anandamide homeostasis.   

Tesseract Medical Research’s AnaQuell^TM is an innovative anandamide supplement formulation developed for individuals experiencing anandamide imbalance and its associated adverse effects. The formulation contains L-citrulline, a critical component for nitric oxide (NO) production, in conjunction with anandamide to promote enhanced blood flow and nutrient delivery to the brain.* The proprietary CyLoc® – DexKey® nutrient delivery technology enables unprecedented absorption of anandamide through the gut wall. The micro-dosing of anandamide in the formulation supports the body’s natural response to mild anxiousness  (non-General Anxiety Disorder), stress, mood changes, and trauma.*

Citations:

¹Scherma, Maria et al. Acta pharmacologica Sinica vol. 40,3 (2019): 309-323. doi:10.1038/s41401-018-0075-x

²Verma RK, et al. Journal of clinical and diagnostic research: JCDR vol. 6,9 (2012): 1612-1613. doi:10.7860/JCDR/2012/4758.2579

³Lotrich FE, et al. Brain, behavior, and immunity vol. 31 (2013): 48-53. doi:10.1016/j.bbi.2012.08.007

⁴Lemtiri-Chlieh, Fouad, and Eric S Levine. Frontiers in cellular neuroscience vol. 16 1023541. 21 Sep. 2022, doi:10.3389/fncel.2022.1023541

⁵Murillo-Rodriguez, Eric et al. Sleep vol. 26,8 (2003): 943-7. doi:10.1093/sleep/26.8.943

Article Summary:

• Quercetin supplements are commercially available as capsules, tablets, intranasal sprays, topical ointments and sprays, and intravenous drips.
• Quercetin intake through the oral route is characterized by  absorption and bioavailability challenges.
• Tesseract’s groundbreaking, proprietary CyLoc® – DexKey® nutrient delivery nanotechnology optimizes the solubility and absorption of quercetin, making it a therapeutic reality.

Quercetin is a plant pigment found in several fruits, vegetables, and grains, including apples, grapes, berries, cherries, onions, broccoli, green tea, and others. Chemically, quercetin is a flavonoid that acts as one of the most potent antioxidants in the diet and promotes various health functions.* Even if you consume 10-100 mg of quercetin daily through different food sources, a quercetin supplement can fill any nutritional gaps. 

Oral quercetin supplements in capsule or tablet form are usually preferred over other delivery routes owing to the ease of intake. This article explains everything about quercetin capsules, their uses and benefits, and why you should include an advanced quercetin supplement in your diet. 

Quercetin Capsules: An Overview

Quercetin is available in different chemical forms, including glycoside, glucuronide, sulfate, and methylated quercetin. Although quercetin glucoside is relatively more soluble than other forms of quercetin, its bioavailability is still low, highlighting the need for formulated quercetin as an oral supplement. 

It is worth noting that the direct extraction of quercetin from natural sources to be used in quercetin capsules or tablets is not feasible owing to its occurrence in various glycosylated forms. Quercetin for supplement formulations is commonly prepared by the acid hydrolysis of rutin — a commodity extracted from different plants.

The following is a brief overview of quercetin supplement formats, including capsules.       

Common types of quercetin supplements

Formulated quercetin supplements are commercially available in oral, intravenous, intranasal, and topical formats. Quercetin capsules contain formulated quercetin that displays a significant increase (above 200%) in blood uptake compared to  unformulated or free quercetin. A quercetin capsule or a coated tablet typically contains 400 – 600 mg of the active nutrient. Because quercetin displays poor solubility in water, supplement formulations contain additional ingredients, such as vitamin C or bromelain — a protein-digesting enzyme extracted from pineapples – for enhanced absorption.   

Benefits of including a quercetin supplement in your diet

The antioxidant properties of quercetin and its role in maintaining the body’s natural inflammatory response promote various health functions inthe heart, kidneys, and immune system.*  

• Quercetin and heart health: Quercetin supplementation helps maintain normal systolic blood pressure and enhances endothelium-dependent vasodilation to promote heart health.*

• Quercetin and renal health: Quercetin promotes kidney health by moderating renal toxicity, limiting programmed cell death (apoptosis), and adverse inflammatory responses.*  

• Quercetin and immune health: Quercetin inhibits histamine release and down-regulates the production of proinflammatory cytokines and inflammatory mediators (leukotrienes) to better maintain balanced immune responses.*   

Side effects of taking a quercetin supplement regularly 

The safety profile of quercetin as a dietary supplement is well established. Clinical studies rarely report adverse effects following supplemental quercetin intake. However, it should be noted that the scientific data for safety assessment is only available for short-term intake (up to 12 weeks) of a daily maximum of 1,000 mg of quercetin. 

Some animal studies highlight the potential of quercetin to enhance nephrotoxic effects in pre-damaged kidneys. Also, quercetin supplementation might be contraindicated concurrent with prescribed medications for high blood pressure and kidney disorders. It is always recommended to consult your healthcare provider before including a quercetin supplement in your diet. 

Absorption challenges associated with quercetin in capsule format

Quercetin displays poor absorption and absorption, which undermines the efficacy of most quercetin capsules. Only 3% – 17% of oral quercetin is estimated to be absorbed in healthy individuals. The poor solubility and absorption of quercetin can be blamed on its low water solubility and instability. The water solubility of quercetin is only 0.01 mg/ml, making it difficult to be absorbed in the gastrointestinal tract.   

The absorption challenges of quercetin can be addressed through innovative nutrient delivery systems, including nanocarriers, liposomes, and polymeric micelles.  

An Advanced Quercetin Capsule Formulation for Promoting Your Overall Health

Tesseract Medical Research has developed two advanced quercetin proprietary complexes that promote cardiovascular and immune health.* The following factors make the Tesseract formulations superior to other oral quercetin supplements available.   

Why is QuerciSorb® the Best Quercetin Supplement?
High-quality ingredients: This hypoallergenic, vegetarian formulation for promoting heart health contains solubility-enhanced quercetin from Sophora japonica (flower) concentrate.*
Nutrient delivery nanotechnology: Tesseract’s proprietary CyLoc® – DexKey® nutrient delivery nanotechnology encases individual quercetin molecules in its smart delivery system and releases them at the desired point in the intestinal tract.
Enhanced absorption and bioavailability: The quercetin-loaded nanomolecules are better absorbed and have enhanced bioavailability than free quercetin.
Micro-dosing: The unprecedented absorption of quercetin enables micro-dosing —  using a lesser amount of quercetin than previously required to achieve a powerful and prompt physiological response.

With optimal absorption and bioavailability, Tesseract’s quercetin capsule formultaions provides a powerful and prompt physiological response to better support your cardiovascular and immune health.*

Do you often experience feelings of nervousness, restlessness, and fatigue? While these can be signs of anxiety, they also indicate a potential deficiency of Coenzyme Q10 or CoQ10—an antioxidant your body produces naturally. If you are trying to determine whether your symptoms are anxiety or something else, then this article is for you.  

Understand the signs of a CoQ10 deficiency and how it correlates with anxiousness. Learn why you should include a CoQ10 supplement and the factors you should consider when choosing the right CoQ10 supplement for your health. Use the links below to jump ahead to different topics on the page.

Are You Experiencing CoQ10 Deficiency?

Coenzyme Q10 (or CoQ10) is vital in both mitochondrial and extra-mitochondrial cell functions. As a lipid-soluble antioxidant, CoQ10 increases fatty acid β-oxidation and oxidative phosphorylation to generate cellular energy (ATP), as well as mediating the expression of several genes.* With a critical role in cellular metabolism, it is not surprising that a deficiency of CoQ10 is associated with various adverse health conditions. 

A CoQ10 deficiency can affect any body part, but particularly the brain, muscles, heart, and kidney tissues, owing to the high energy demands in these organs. A CoQ10 deficiency can lead to mitochondrial dysfunction in brain cells, which is associated with anxiety. As a result, CoQ10 deficiency and anxiousness are much more closely related than previously thought.*

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Factors Causing A CoQ10 Deficiency

A CoQ10 deficiency is categorized into primary and secondary deficiencies. A primary CoQ10 deficiency is caused by genetic mutations; whereas, a secondary deficiency results from different conditions of the heart, kidney, liver, and other vital organs and specific pharmacotherapies, such as statins. The following table highlights the three potential factors leading to a CoQ10 deficiency¹.   

Factors Causing A CoQ10 Deficiency
Reduced dietary intake	The normal range of CoQ10 concentration in plasma is 0.8 – 1.2 mg/L. CoQ10 intake in the form of organ meat, soy oil, sardines, and peanuts helps maintain the endogenous level of the antioxidant. Reduced dietary intake can result in a CoQ10 deficiency.
Impaired biosynthesis	CoQ10 is naturally produced in the liver. Aging and various health conditions can lead to a gradual decrease in CoQ10 synthesis and an increase in its degradation. A deficit due to impaired biosynthesis cannot be compensated for by diet and results in a CoQ10 deficiency.
Increased usage of CoQ10 in the body	Certain health conditions can result in an increased usage of CoQ10 by cells, thereby depleting the overall CoQ10 level in plasma and resulting in a CoQ10 deficiency.

How are CoQ10 Deficiency and Anxiousness Related?

The perception of threat activates the sympathetic nervous system, triggering an acute stress response of ‘fight’ or ‘flight.’ Being consistently anxious is a state of uneasiness and enhanced vigilance in the absence of an immediate threat. Cognitive and behavioral distress responses frequently accompany consistent anxious feelings.   

Although the exact pathophysiology of having these feelings of anxiousness is not clearly understood, much effort has been made to explore the underlying reasons. Research suggests that mitochondrial dysfunction is a contributing factor to the underlying mechanisms². In brain tissues, a CoQ10 deficiency can cause ataxia—a state of impaired balance or coordination. Prolonged ataxia can often cause intense feelings of anxiousness, highlighting the correlation between a CoQ10 deficiency and feeling anxious.

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Including a CoQ10 Supplement in Your Diet to Address non-GAD Anxiousness* 

CoQ10 supplementation has been found to address several conditions associated with primary and secondary CoQ10 deficiencies.* The following table highlights how a CoQ10 supplement helps manage these situations.* 

CoQ10 Supplementation to Address Long-Term Anxiousness – How is Long-Term Anxiousness different from GAD?
Positive effects on cognitive impairment related to mitochondrial dysfunction: There is a hypothesis that a CoQ10 deficiency can contribute to mitochondrial impairments, which is reflected through cognitive, affective, and energy disturbances. A study has explored the potential interaction of mitochondrial dysfunction and an increase in inflammatory cytokines as contributing factors3. CoQ10 supplementation has shown positive effects on cognitive impairment and fatigue in several neurological conditions related to mitochondrial dysfunction4.*
CoQ10 supplementation and functioning of the cerebellum: Clinical studies have shown the role of CoQ10 supplementation (300 – 3,000 mg/ day) in enhancing the functioning of the cerebellum—a vital component in the human brain that regulates motor movement and controls balance5.*

Types of CoQ10 Supplements 

Commercially available CoQ10 supplements are mostly chewable tablets, capsules, liquid syrups, and oral sprays. It is worth noting that when supplemental CoQ10 is produced through yeast fermentation, it is obtained as crystals that are not well absorbed from the gastrointestinal tract. The poor absorption of CoQ10 in the intestines affects its efficacy through the oral route.  

The poor absorption and bioavailability of CoQ10 in oral supplements is due to: 

• The molecular weight of CoQ10: A relatively high molecular weight of CoQ10 adversely affects its absorption in the gastrointestinal tract.

• Limited solubility: Although CoQ10 is a lipophilic compound, it displays limited solubility in lipids and is insoluble in water. 

• Instability: The frequent inter-conversion of CoQ10 between the oxidized (ubiquinone) and reduced (ubiquinol) forms also adversely affects its absorption in the body.

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Ubiquinone or Ubiquinol? 

CoQ10 exists in three oxidation states:

• The fully oxidized Ubiquinone form (CoQ10)

• The fully reduced Ubiquinol form (CoQ10H2)

• The radical Ubisemiquinone intermediate (CoQ10H.)

Both the ubiquinone and ubiquinol forms coexist in the body and regenerate each other through sequential redox reactions. Ubisemiquinone is a highly unstable, intermediate form of CoQ10. There has been much debate about the most effective form of CoQ10 supplementation. 

Regardless of the initial dietary form of CoQ10 (ubiquinone or ubiquinol), it remains in the blood and lymphatic fluid in the ubiquinol form. 

It is worth noting that several clinical studies have established that there is no significant difference between the bioavailability of ubiquinone and ubiquinol supplements⁶. 

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How to Choose the Best CoQ10 Supplement?

The process of CoQ10 absorption is complex, and there is variability in the bioavailability of CoQ10 supplements depending on their formulations. It is essential that CoQ10 crystals produced through yeast fermentation are dispersed into single CoQ10 molecules to enable optimal bioavailability. Research³ indicates that in the absence of such crystal dispersion in supplemental CoQ10 formulations, bioavailability is limited by 75 percent.  

CoQ10 absorption is subjective, and the level of CoQ10 in the blood following the intake of oral supplements can vary widely depending on the individual and the type of formulation. When selecting a CoQ10 supplement to promote your mental well-being,* you should consider the following factors:

• Bioavailability: The bioavailability of a CoQ10 supplement largely depends on carrier lipids and the solubilization of the formulation. The proportion and addition of preservatives, such as vitamin C, to supplement formulations can also affect the bioavailability of CoQ10.

• Absorption: For enhanced absorption of a CoQ10 supplement, the polymorphic crystals should be disassociated to single CoQ10 molecules throughout the formulation’s shelf life.  

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CoQ10 Supplement Formulations to Promote Mental Well-being*

The bioavailability and absorption of CoQ10 depend on the supplement’s formulation. The limited ability of CoQ10 to cross the blood-brain barrier affects the responsiveness of certain neurological conditions to CoQ10 supplementation. Several novel approaches have been implemented to enhance the solubility and absorption of CoQ10 formulations, including:

• Nanoparticles
• Solid dispersion systems 
• Microcapsules
• Cyclodextrin inclusion compounds
• Nano-liposomes 

For neurological conditions associated with a CoQ10 deficiency, the analogs of CoQ10 precursors—such as β-resorcylic acid (β-RA)—have been explored in an attempt to enhance endogenous CoQ10 biosynthesis. Among the novel approaches, encasing CoQ10 with cyclodextrins has been found to significantly enhance CoQ10 absorption and bioavailability, suggesting this delivery process is superior to oral formulations that feature only uncomplexed CoQ10⁷.

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FAQs: Frequently Asked Questions About CoQ10 Deficiency

Can a CoQ10 supplement help stabilize mood?

Several neurological conditions are linked to oxidative stress and mitochondrial dysfunction. Although studies have explored the role of CoQ10 as an antioxidant to promote mental and emotional well-being, its role as a mood stabilizer is still being investigated. 

Can I take a CoQ10 supplement with a prescription medication for mental health? 

Although the safety profile of CoQ10 is well established, there might be potential contraindications when combined with a prescription medication. Consult with your healthcare provider before including a CoQ10 supplement in your diet to promote mental health.  

How do I choose the best CoQ10 supplement?

The efficacy of a CoQ10 supplement is determined in part by the delivery technology used in the formulation. Tesseract’s CoQ10 Pro® is an innovative supplement formulation that uses the proprietary CyLoc^® – DexKey^® nutrient delivery nanotechnology for unparalleled absorption of CoQ10 in the intestinal tract. The unprecedented absorption of CoQ10 enables micro-dosing, meaning you can take CoQ10 in much lower amounts than previously required to accomplish the desired therapeutic benefits to support your mental health.*  

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Citations:

¹Manzar, Haider et al. International journal of molecular sciences vol. 21,23 9299. 6 Dec. 2020, doi:10.3390/ijms21239299

²Liu L, et al. Translational psychiatry vol. 13,1 216. 21 Jun. 2023, doi:10.1038/s41398-023-02518-y

³Mantle, David, and Alex Dybring. Antioxidants (Basel, Switzerland) vol. 9,5 386. 5 May. 2020, doi:10.3390/antiox9050386

⁴Bagheri, Shokufeh et al. Frontiers in neuroscience vol. 17 1188839. 23 Jun. 2023, doi:10.3389/fnins.2023.1188839

⁵Mantle, David et al.Antioxidants (Basel, Switzerland) vol. 11,1 2. 21 Dec. 2021, doi:10.3390/antiox11010002

⁶López-Lluch G, et al. Nutrition (Burbank, Los Angeles County, Calif.) vol. 57 (2019): 133-140. doi:10.1016/j.nut.2018.05.020

⁷Pastor-Maldonado, Carmen J et al. vol. 21,22 8432. 10 Nov. 2020, doi:10.3390/ijms21228432

• Anandamide supplements support the endocannabinoid system and help maintain anandamide homeostasis to support healthy neurological function.* 
• The best anandamide supplement is characterized by the ingredients it contains, its enhanced absorption and the bioavailability of active nutrients in a micro-dosing format.  
• Tesseract’s AnaQuell® utilizes the proprietary CyLoc® – DexKey® nutrient delivery nanotechnology for unprecedented absorption of anandamide, to enhance its therapeutic potential. 

Anandamide, or the ‘bliss’ molecule, is a vital component of the body’s endocannabinoid system (ECS) that helps regulate and control several critical body functions.* Although our body produces anandamide naturally, certain factors can adversely impact the body’s ability to synthesize and maintain sufficient anandamide levels. A suboptimal anandamide level can adversely affect the entire body, particularly influencing the ability to cope with stress. 

The systemic intake of anandamide in the form of nutritional supplements has been associated with regulating neuronal signaling, thereby providing significant support for individuals experiencing stress and anxiousness (non-General Anxiety Disorder).* But what is the best anandamide supplement you can include in your regular diet? Understanding the key features of anandamide supplements and how these features can make a difference in positively influencing our emotional and mental well-being will help you select the right supplement formulation.  

Key Features of Best Anandamide Supplements

Let’s examine the intrinsic and extrinsic factors that affect anandamide levels in the body:

• Genetic predisposition: Research shows that inhibiting the activity of the FAAH enzyme will limit the breakdown of anandamide, thereby enhancing its level.¹ However, some individuals are genetically predisposed to higher anandamide levels due to a variant FAAH gene.

• Stress-induced environments: Research highlights that stress-induced environments trigger a dip in anandamide levels, with continuous exposure to high-stress environments resulting in the down-regulation or the loss of the body’s CB1 receptors that anandamide binds to². 

• Aging: Age-dependent adaptive changes of endocannabinoid metabolism have also been found to adversely influence the level of anandamide in the body. 

• Poor lifestyle choices: The runner’s high experienced by some individuals during and after endurance exercises is attributed to the release of endocannabinoids, particularly anandamide. A lack of physical activities and poor sleep habits, including an irregular sleep schedule, can adversely influence the circulating level of anandamide.  

Anandamide supplements support the endocannabinoid system by providing an adequate amount of anandamide to better regulate various physiological functions.* When looking for the best anandamide supplement, it is important to consider features of the formulation, including the quality of ingredients, nutrient delivery system, and recommended use. The following table highlights what you should look for to determine the best anandamide supplement.

What to Look for in Determining the Best Anandamide Supplement
Ingredients: Although the cellular uptake of anandamide is not well understood, studies indicate that a low concentration of anandamide enhances nitric oxide (NO) levels in platelet cells in the blood.* Binding of extracellular anandamide to cannabinoid receptors leads to the activation of nitric oxide synthetase (NOS) and intracellular nitric oxide production from L-arginine.3 Supplement formulations containing ingredients such as L-citrulline (a natural precursor of L-arginine) enhance overall  NO production, promoting blood flow and nutrient delivery to the brain.*
Optimal Absorption: Gastrointestinal enzymes hinder the intact absorption of anandamide in free form through the gut wall. Formulations using encapsulation techniques that trap anandamide molecules in nanocarriers are more readily absorbed through the gut wall.*
Micro-Dosing: Anandamide intake in significantly higher amounts (3 mg/ kg) produces anxiety-inducing effects due to the overstimulation of CB1 receptors that anandamide binds to. This, in turn, can disrupt the brain’s reward circuitry. A supplement formulation that enables micro-dosing (the intake of anandamide in lesser amounts than previously required) helps maintain a sufficient level of anandamide in the body.

The best anandamide supplement formulation enhances the absorption and bioavailability of anandamide in micro-doses, making the ‘bliss molecule’ a therapeutic reality.   

An Advanced Anandamide Formulation that Supports Your Health

Tesseract Medical Research’s AnaQuell® supplement is an innovative anandamide formulation that supports the body’s natural response to stress and anxiety (non-GAD).* The combination of anandamide and L-citrulline in Tesseract’s proprietary complex enhances nitric oxide production.* AnaQuell utilizes Tesseract’s proprietary CyLoc® – DexKey® nutrient delivery nanotechnology that solubilizes the anandamide, enabling its unprecedented absorption across the gut wall.*  The enhanced absorption and bioavailability of the anandamide in AnaQuell allow for micro-dosing of the active ingredient to promote emotional health and mental well-being.* 

Hypoallergenic AnaQuell formulations available in both quick- and sustained-release formats are manufactured in a Good Manufacturing Practices (GMP) – compliant environment, using scientifically advanced analytical techniques and a well-designed quality control system.   

Citations:

¹Ahn K, et al. Expert opinion on drug discovery vol. 4,7 (2009): 763-784. doi:10.1517/17460440903018857

²Morena M, et al. Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology vol. 41,1 (2016): 80-102. doi:10.1038/npp.2015.166

³Maccarrone, Mauro, et al. Journal of Biological Chemistry, vol. 275, no. 18, 2000, pp. 13484-13492, https://doi.org/10.1074/jbc.275.18.13484. Accessed 18 Aug. 2024.

Article Summary:

• Glutathione supplementation supports a wide range of health functions, in the nervous system, the gastrointestinal system, immune function, the endocrine system, as well as skin and hair health.* 
• Although intravenous or intramuscular glutathione injections provide better absorption of glutathione than their oral counterparts, these injections require medical supervision and might not be compatible with certain health conditions. 
• Tesseract’s unique glutathione supplement formulation uses CyLoc® – DexKey® nutrient delivery nanotechnology to enhance glutathione’s palatability, absorption and bioavailability. 

The aging process is typically associated with increased production of reactive oxygen species (ROS) in the body. Excessive ROS  cause oxidative stress and can severely damage cellular components, including DNA, lipids, proteins, and organelle membranes. The decline in the body’s natural antioxidant defense system and the damage caused by ROS contribute to the aging process. 

Glutathione, which acts as an antioxidant, is present in every body cell and is crucial in eliminating ROS and addressing oxidative stress.* Glutathione’s critical role as a detoxifying agent and free radical scavenger is why it is often referred to as the master antioxidant. Impairment of glutathione function in the brain is linked to the loss of neurons during the aging process and can result in  neurological disorders. Low levels of glutathione have also been associated with deteriorating gastrointestinal (GI) and endocrine health, as well as the health of skin and hair. 

One of the best ways to enhance depleted glutathione levels in the body is by including a glutathione supplement in your regular diet. Let’s examine the benefits of glutathione supplements and why you should include an advanced formulation to support healthy aging.*  

What Are Glutathione Supplement Benefits? 

Glutathione supplements vary based on the mode of delivery, including oral, intranasal, intravenous/intramuscular, and nebulized. The following table highlights the benefits of glutathione supplements and how they promote various health functions.*

Benefits of Glutathione Supplementation
Health Function	Benefits
Nervous system*	Glutathione supplementation provides neuronal defense against damage caused by free radicals.1
Gastrointestinal system*	Several studies indicate a direct correlation between low glutathione concentration and mucosal damage in various adverse conditions of the GI tract.2 Glutathione supplements protect mucosal cells in the GI tract from oxidative stress.3
Immune Function*	Glutathione supplements help maintain a delicately balanced intermediate glutathione level in lymphoid cells for optimal immune system functioning.4
Endocrine System*	As a detoxifying agent and antioxidant, glutathione protects the liver from oxidative stress.5 Glutathione can help reduce elevated liver enzymes and support hepatic metabolism.6
Skin and Hair	Topical and intravenous glutathione supplements can help promote healthy skin and hair via their antioxidant mechanisms.7

Although oral glutathione is the most popular delivery method for glutathione supplementation, it has not been always considered the most effective. The rapid absorption of oral glutathione in the gastrointestinal tract and its poor bioavailability are the key factors contributing to the low efficacy of oral glutathione supplements. 

Alternative delivery methods, such as intravenous or intramuscular glutathione injections, have been explored because they bypass the absorption of glutathione in the gastrointestinal tract, allowing it to directly  enter the bloodstream . These injections are particularly trending for skin care and wellness applications. However, IV glutathione drips require medical supervision and might not be compatible with certain health conditions.

When considering adding an oral glutathione supplement to your diet, it is worth selecting an advanced formulation that ensures optimal bioavailability and absorption.  

Incorporating An Advanced Glutathione Supplement Into Your Diet

Tesseract Medical Research’s SafeCell® is a unique supplement formulation that solves the common challenges of palatability, bioavailability, and absorption of glutathione. SafeCell’s acetylated form of glutathione formula utilizes the proprietary CyLoc® – DexKey® nutrient delivery technology that enables unprecedented absorption of glutathione. SafeCell promotes the optimal functioning of other antioxidants, supports natural detoxification pathways, modulates oxidative stress, and because it crosses the blood-brain barrier, it supports optimal cellular and neurological function.* The Tesseract Detoxification Solution helps you maintain optimal health as we age.*

Citations:

¹Park, Min Kyu et al. International journal of molecular sciences vol. 24,3 2950. 2 Feb. 2023, doi:10.3390/ijms24032950

²Loguercio C, Di Pierro M. Italian journal of gastroenterology and hepatology vol. 31,5 (1999): 401-407.

³Bhattacharyya, Asima et al. Physiological reviews vol. 94,2 (2014): 329-54. doi:10.1152/physrev.00040.2012

⁴Dröge, W, and R Breitkreutz. “Glutathione and immune function.” The Proceedings of the Nutrition Society vol. 59,4 (2000): 595-600. doi:10.1017/s0029665100000847

⁵Vairetti, Mariapia et al. Antioxidants (Basel, Switzerland) vol. 10,3 364. 28 Feb. 2021, doi:10.3390/antiox10030364

⁶Honda, Yasushi et al. BMC gastroenterology vol. 17,1 96. 8 Aug. 2017, doi:10.1186/s12876-017-0652-3

⁷Weschawalit, Sinee et al. “Glutathione and its antiaging and antimelanogenic effects.” Clinical, cosmetic and investigational dermatology vol. 10 147-153. 27 Apr. 2017, doi:10.2147/CCID.S128339

Onions are a staple in kitchens around the world, but their benefits go far beyond a flavoring agent. These nutrient-dense vegetables are packed with antioxidants, the most notable being quercetin. Quercetin is a powerful plant compound linked to a wide range of health benefits, from supporting immune function to promoting cardiovascular health. However, do dietary sources alone provide a therapeutic dose, or is supplementation worth considering? Let’s explore the science behind quercetin and what makes supplementation of quercetin a valuable addition to your wellness routine. 

In this blog we’ll aim to answer  common questions about the benefits of quercetin supplementation, including how a quercetin supplement can support health and wellness. Use the links below to jump ahead to a topic of interest.

Quercetin: Origin and Potential Applications	How Quercetin Supports Cardiovascular Health
Quercetin Supports Healthy Immune Function	Quercetin and Healthy Aging
Factors Affecting Quercetin’s Absorption	Quercetin Supplement Formulations
FAQs: Frequently Asked Questions

Quercetin: Origin and Potential Applications

Quercetin is a flavonoid (a type of plant compound known for its antioxidant properties) found in various fruits and vegetables. Some of the richest sources include onions, capers, apples, berries, grapes, green leafy vegetables, and honey, as well as green and black tea. Onions contain a high amount of quercetin, with the outer layers containing the highest concentration.¹ 

Quercetin’s unique biological properties are linked to maintaining the body’s natural inflammatory response and limiting oxidative stress to promote overall health and wellness.*

Quercetin displays antioxidant and immunomodulatory properties,*² in addition to possessing mast cell stabilization and cytoprotective activities of the gastrointestinal tract.*⁴ Quercetin’s benefits are attributed to the following two primary properties of the flavonoid:  

• Antioxidative properties of quercetin: Quercetin’s antioxidant properties enable it to regulate both  enzyme-mediated and non-enzyme-dependent antioxidant defense systems.* Quercetin also regulates cell signaling pathways triggered by reactive oxygen species (ROS) to enhance  the antioxidant defense system.*⁵ 

• Immunomodulatory properties of quercetin: Quercetin supports a healthy immune response by up-regulating beneficial immune cells, such as dendritic cells, T-helper cells, neutrophils, and microglia, making quercetin a promising botanical compound for responding to various immune-related conditions.*^6,7,8,9

The following table summarizes the potential beneficial applications of quercetin:

System	Beneficial Applications
Cardiovascular Health*	Quercetin inhibits the oxidation of low-density lipoproteins (LDL) and helps maintain normal blood pressure levels and healthy arteries.* 10 Learn more about quercetin for heart health support.*
Immune Health*	Quercetin down-regulates the release of proinflammatory cytokines and histamine, limiting adverse immune and allergic responses.* 11 Learn more about quercetin’s immune support properties.*
Renal Health*	Quercetin’s antioxidant properties support the reduction of oxidative stress on the kidneys, promoting healthy kidney function.* 12 Learn more about quercetin for kidney health.*
Skin Health*	Quercetin can help maintain healthy skin integrity,* which can be compromised by UV radiation and exposure to toxic chemicals by reducing oxidative stress, promoting a healthy inflammatory response, and limiting collagen degradation*. Additionally, quercetin plays a beneficial role in skin restoration by supporting skin hydration through its moisturizing effects.* 13 Learn more about quercetin’s skin benefits.*
Gastrointestinal Health*	Quercetin helps maintain gut microbial diversity and a normal inflammatory response in the gastrointestinal tract.* 14 Learn more about quercetin and gut health.*

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How Does Quercetin Support Cardiovascular Health? 

Oxidative stress is closely related to several cardiovascular disorders. The antioxidant and immuno-supportive properties of quercetin mitigate oxidative stress and the presence of free radicals that can damage cardiovascular tissues.* The following table summarizes how quercetin benefits heart health:* 

Quercetin and Heart Health*
Inhibiting Oxidation of Low-Density Lipoprotein (LDL)*	Quercetin inhibits oxidative damage to LDL by down-regulating cell signaling pathways, particularly the TLR-NF-κB pathway.* 15
Helping Maintain Normal Blood Pressure*	A meta-analysis found that quercetin supplementation (500 mg or more daily) helped those with high blood pressure maintain healthier blood pressure levels.* 16
Inhibiting Expression of Adhesion Molecules*	Quercetin down-regulates the expression of specific cell surface proteins called adhesion molecules in aortic endothelial cells to help maintain healthy arteries.* 17
Maintaining a Normal Inflammatory Response in Adipocytes and Support Healthy Glucose Metabolism*	Quercetin helps maintain a normal inflammatory response in adipocytes and promotes healthy glucose and insulin metabolism, thus supporting cardiovascular health.* 18

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Quercetin Supports Healthy Immune Function

Quercetin alters several cell signaling pathways to down-regulate adverse allergic reactions and help maintain normal inflammatory responses.* The following table highlights how quercetin supports healthy immune function and strengthens the body’s natural defense mechanisms:*    

Quercetin and Immune Function
Supporting a healthy histamine response: Quercetin promotes beneficial stabilization of mast cells, which release histamine — a signaling chemical involved in local allergic and immune response communication.* 19
Inhibiting proinflammatory cytokine production: Quercetin down-regulates cell signaling pathways (NF-κβ1 and Iκβ), resulting in inhibited production of proinflammatory cytokines and promoting a healthy inflammatory response.* 20
Inhibiting the production of leukotrienes: Quercetin is a potent inhibitor of leukotrienes — the biochemical mediators produced in white blood cells that cause adverse immune responses, such as the tightening of airway muscles.* 21
Enhancing Th1/Th2 balance: Quercetin promotes the balance between the two types of T-helper (Th) cells — Th1 and Th2 cells — promoting a healthy adaptive immune response.* 22
Down-regulation of antigen-specific IgE antibody formation: Quercetin inhibits the formation of immunoglobulin E (IgE) antibodies that trigger antigen-specific allergic reactions.* 23

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Quercetin and Healthy Aging

The following table highlights several mechanisms through which quercetin promotes healthy aging:

Quercetin Supports Healthy Aging*
Limiting bone mass and bone mineral loss Quercetin upregulates bone mineralization to promote bone health and limit bone loss.*
Upregulating SIRT1 cell signaling pathway The SIRT1 protein signaling pathway promotes healthy mitochondrial function. Research 1 indicates quercetin targets SIRT1 to upregulate multiple beneficial aging-related cellular processes.*
Mitigating the effects of aging Senescence-associated secretory phenotype (SASP) — a set of characteristics displayed by aging (senescent) cells, including the secretion of high levels of inflammatory cytokines, growth factors, immune modulators, and proteases. Quercetin limits the expression of senescent cell markers and inhibits the production of SASP.*
Exerting benefits on the central nervous system It has been found 2 that quercetin protects against age-related neurodegeneration.* Quercetin regulates the SIRT1/Nrf2/HO-1 cell signaling pathway, which counteracts and limits oxidative stress-mediated neuronal death 3.*
Limiting glutathione depletion Quercetin enhances the activity of superoxide dismutase and catalase, thereby beneficially inhibiting glutathione depletion.* By helping to maintain mitochondrial glutathione levels, quercetin protects against free radical damage to multiple cellular components.*
Addressing immunosenescence Quercetin has a direct beneficial effect on up-regulating the positive functions of multiple immune cells, including inhibiting histamine and serotonin release from intestinal mast cells.* The role of quercetin in enhancing immune resilience helps promote healthy aging.
Inhibiting the activity of NF-κB signaling pathway Quercetin inhibits 4 the activity of the NF-κB signaling pathway, which protects cardiac tissues from damage caused by free radicals.*

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Factors Affecting Quercetin’s Absorption in the Body

Post-ingestion,  quercetin undergoes a process called deglycosylation and is then absorbed by the small intestine.²⁴ Post-absorption, quercetin is metabolized in various organs, primarily the small intestine and then the liver. Quercetin and its metabolites are finally excreted mainly through the urine. 

Historically, quercetin supplements have shown poor absorbability and, therefore, have decreased bioavailability.²⁵ The key factors limiting quercetin’s absorption and bioavailability in the body are:

• Low Aqueous Solubility (does not dissolve well in water)

• Poor Permeability (does not easily pass through the intestinal barrier)

• Short Biological Half-Life (quick elimination from the body)

• Instability in the stomach and intestine (easily broken down by stomach acid and other digestive substances before reaching systemic circulation)

• Extensive First-Pass Metabolism in the Liver (rapid biotransformation into other molecules before reaching systemic circulation)

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Quercetin Supplement Formulations

Quercetin accounts for up to 75 percent of an individual’s daily estimated flavonoid intake, ranging from 50 – 800 mg/day.²⁶ Quercetin’s daily intake through food sources primarily depends on consuming fruits, vegetables, and tea. So, even if 10 – 100 mg of quercetin is consumed daily through different food sources, a supplement formulation can fill nutritional gaps to help achieve quercetin’s many health-promoting benefits.* 

Commercially formulated quercetin supplements are available in oral (tablet, capsule, powder), intravenous (injectable formulations), intranasal (spray, nasal drops), and topical (ointments, gels, sprays) formats. A quercetin capsule or tablet typically contains 400 – 600 mg of the active nutrient.

Novel Formulations

Novel supplement formulations that have innovative delivery systems can overcome quercetin’s absorbability and bioavailability challenges²⁷*. The following benefits of nano-formulated molecules enhance the overall efficacy of quercetin supplement absorption:

• Nanoformulated molecules achieve a larger surface area per molecule than their raw material counterparts.  

• Such molecules can be customized for targeted delivery to the desired part of the intestine, protecting the molecules from early degradation and promoting their optimal absorption.

• Nanoformulated nutrient delivery also enables the controlled release of quercetin molecules at the desired point in the intestinal tract.  

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FAQs: Frequently Asked Questions About Quercetin Supplement Benefits 

Are there side effects to taking a quercetin supplement?

There is no significant reported toxicity or side effects of quercetin, and its intake as a nutritional supplement at one gram daily is generally considered safe. However, there is limited data on the prolonged usage of quercetin at or above one gram daily for longer than 12 weeks.²⁸ Ingesting too high an amount of quercetin can cause unwanted effects, such as depletion of intracellular glutathione content.²⁸ 

The complexity of potential interactions of prolonged quercetin intake dictates that quercetin use as a supplement should begin only after medical consultation.  

Can I take a quercetin supplement with a prescription medicine?

Quercetin can interact with certain prescription medications by reducing their absorption and effectiveness and raising the risk of side effects. Consult a healthcare practitioner to be informed about potential interactions and contraindications before initiating  quercetin supplementation. 

How do I determine the efficacy of a quercetin supplement?

The best indication of the efficacy of a quercetin supplement lies in the enhanced absorption and bioaccessibility of the active nutrient molecules. 

QuerciSorb QR^® — innovative quercetin supplement formulations developed by Tesseract Medical Research in a quick-release or sustained-release format incorporate a proprietary nanomolecular nutrient delivery technology (CyLoc® – DexKey®) that enhances quercetin’s solubility and absorption. 

QuerciSorb Immuphore SR^® contains quercetin, as well as additional immune-supporting ingredients, including vitamins C and D and zinc, to promote healthy immune function.* 

Tesseract’s proprietary CyLoc® – DexKey® nutrient delivery nanotechnology further enhances the absorption of quercetin molecules at the desired point in the intestinal tract. The unprecedented absorption unlocks quercetin’s many health-promoting benefits, including supporting optimal cardiovascular health and immune function.*

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References:

1. Lee J, Mitchell AE. J Agric Food Chem 2011;59(3):857-863. doi:10.1021/jf1033587

2. Aghababaei F, Hadidi M. Pharmaceuticals (Basel) 2023;16(7):1020. Published 2023 Jul 18. doi:10.3390/ph16071020

3. Ding Y, Che D, Li C, et al. Int Immunopharmacol 2019;66:185-197. doi:10.1016/j.intimp.2018.11.025

4. Martín MJ, La-Casa C, Alarcón-de-la-Lastra C, et al. Z Naturforsch C J Biosci 1998;53(1-2):82-88. doi:10.1515/znc-1998-1-215

5. Aghababaei F, Hadidi M. Pharmaceuticals (Basel) 2023;16(7):1020. Published 2023 Jul 18. doi:10.3390/ph16071020

6. Zhou Y, Qian C, Tang Y, et al. Phytother Res 2023;37(11):4999-5016. doi:10.1002/ptr.7966

7. Huang RY, Yu YL, Cheng WC, et al. J Immunol 2010;184(12):6815-6821. doi:10.4049/jimmunol.0903991

8.Yu ES, Min HJ, An SY, et al. Biochem Pharmacol 2008;76(1):70-78. doi:10.1016/j.bcp.2008.03.020

9. Liu J, Li X, Yue Y, et al. Cell Mol Immunol 2005;2(6):455-460.

10. Kao TK, Ou YC, Raung SL, et al. Life Sci 2010;86(9-10):315-321. doi:10.1016/j.lfs.2009.12.014

11. Mlcek J, et al. Molecules (Basel, Switzerland) vol. 21,5 623. 12 May. 2016, doi:10.3390/molecules21050623

12. Xu D, et al. Molecules (Basel, Switzerland) vol. 24,6 1123. 21 Mar. 2019, doi:10.3390/molecules24061123

13. Ha AT, et al. International Journal of Molecular Sciences vol. 23,1 433. 31 Dec. 2021, doi:10.3390/ijms23010433

14. Sun L, et al. Molecules (Basel, Switzerland) vol. 27,10 3269. 19 May. 2022, doi:10.3390/molecules27103269

15. Bhaskar S, et al. Immunobiology vol. 216,3 (2011): 367-373. doi:10.1016/j.imbio.2010.07.011

16. Serban M-C, et al. Journal of the American Heart Association vol. 5,7 e002713. 12 Jul. 2016, doi:10.1161/JAHA.115.002713

17. Li C, et al. Redox Biology vol. 9 (2016): 104-113. doi:10.1016/j.redox.2016.06.006

18. Wang Y, et al. Nutrients vol. 16,8 1102. 9 Apr. 2024, doi:10.3390/nu16081102

19. Shaik Y, et al. Central-European Journal of Immunology vol. 43,4 (2018):476-481. doi:10.5114/ceji.2018.81347

20. Cheng S-C, et al. International Journal of Molecular Sciences vol. 20,12 2957. 17 Jun. 2019, doi:10.3390/ijms20122957

21. Loke WM, et al. Biochemical Pharmacology vol. 75,5 (2008):1045-1053. doi:10.1016/j.bcp.2007.11.002

22. Ke X, et al. Autoimmunity vol. 56,1 (2023):2189133. doi:10.1080/08916934.2023.2189133

23. Mlcek J, et al. Molecules (Basel, Switzerland) vol. 21,5 623. 12 May. 2016, doi:10.3390/molecules21050623

24. Almeida AF, Borge GIA, Piskula M, et al. Compr Rev Food Sci Food Saf 2018;17(3):714-731. doi:10.1111/1541-4337.12342

25. Alizadeh SR, Savadkouhi N, Ebrahimzadeh MA. Expert Opin Drug Discov 2023;18(10):1117-1132. doi:10.1080/17460441.2023.2241366

26. de Vries JH, Janssen PL, Hollman PC, et al. Cancer Lett 1997;114(1-2):141-144. doi:10.1016/s0304-3835(97)04645-4

27. Tomou, Ekaterina-Michaela et al. Pharmaceutics vol. 15,6 1656. 5 Jun. 2023, doi:10.3390/pharmaceutics15061656

28. Andres S, Pevny S, Ziegenhagen R, et al. Mol Nutr Food Res 2018;62(1):10.1002/mnfr.201700447. doi:10.1002/mnfr.201700447

28. Jazvinšćak JM, Čipak GA, Vuković L, et al. Naunyn Schmiedebergs Arch Pharmacol 2012;385(12):1185-1197. doi:10.1007/s00210-012-0799-y

Although your blood pressure changes throughout the day based on your activities, consistently elevated blood pressure is the root cause of several cardiovascular disorders. You might not be aware of experiencing high blood pressure until it causes a severe health condition. High blood pressure is often called a ‘silent killer’ because it can quietly damage blood vessels and adversely affect your heart health. Therefore, it is essential to have your blood pressure checked regularly. 

Diet, exercise, and prescription medications (if required) are critical to maintaining a normal blood pressure level. A blood pressure support supplement can also promote your cardiovascular health and help keep your blood pressure healthy.*  

Get the answers to questions about blood pressure support supplements, including how they help maintain normal blood pressure and the best formulations that promote cardiovascular health. Use the links below to jump ahead to different topics on the page.

Understanding Your Blood Pressure

Your blood pressure is recorded as two numbers —

1. Systolic blood pressure: This upper number indicates how much pressure the blood exerts against the artery walls when your heart contracts. This number rises steadily with age as arteries stiffen, and especially when plaque builds up, which can lead to cardiovascular disorders. 
2. Diastolic blood pressure: This lower number indicates how much pressure the blood exerts against the artery walls when your heart muscles rest between contractions. 

A blood pressure of 120/80 mm of Hg (millimeters of mercury) is considered normal. However, consistently elevated systolic blood pressure readings of 130-139 mm of Hg or higher and diastolic pressure readings of 80-89 mm of Hg call for lifestyle changes and potentially medications prescribed by ahealth-care professional.     

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Ways to Maintain A Healthy Blood Pressure

Understanding your blood pressure level is the key to making dietary and lifestyle changes for a healthy heart, kidneys, and other organs. The following table summarizes ways to support a healthy blood pressure within the normal range.  

How to Maintain A Healthy Blood Pressure
Healthy Diet	Organic Fruits, vegetables, whole grains, dairy products, grass-fed  meats, beans, nuts, and vegetable oils should be included in the diet.  Foods high in saturated fat, seed oils like vegetable oil, canola and peanut oil, refined salt (sodium), and sugar should be limited.  The amount of potassium in the diet should be increased. Foods high in potassium include bananas, avocados, apricots, potatoes, leafy green vegetables as well as nuts and beans.
Regular Exercise	Aerobic exercises, such as brisk walking, help the heart beat harder and pump more blood with less effort to lower the pressure of blood against the arteries1.  Regular moderate-intensity aerobic exercise helps maintain a healthy weight and a lower blood pressure.2
Weight Management	Being overweight increases your risk of high blood pressure.  Healthy weight management through diet and lifestyle changes can lower arterial stiffness and enhance blood vessel function3.
Stress Management	Managing stress improves your emotional and physical health and may help maintain a healthy blood pressure4.  Some commonly used stress management techniques include exercising, meditating, and deep breathing.
Limiting Alcohol and Smoking	Because consuming too much alcohol raises blood pressure, it should be limited to one drink daily for women and two drinks daily for men5.  Cigarette smoking is closely linked to rising blood pressure and heart rate. Quitting smoking is the best way to maintain normal blood pressure6.

Vitamins, Minerals, and Other Nutrients to Help Maintain Normal Blood Pressure 

A wide range of vitamins, minerals, and botanicals have been shown to protect the heart from the damaging effects of oxidative stress and help maintain the normal inflammatory responses in cardiac cells.* The following table highlights some essential vitamins, minerals, and other nutrients that can also be taken in blood pressure support supplements. 

Vitamins, Minerals, and Other Nutrients as Blood Pressure Support Supplements
Vitamins	Vitamin C: An antioxidant that neutralizes superoxide anions and limits peroxynitrite formation contributing to improved endothelial function and vasodilation, promoting healthy blood pressure.7,8  Vitamin E: Clinical trials indicate that vitamin E exerts antioxidant effects and helps blood vessels dilate, thus helping to maintain normal blood pressure.9
Minerals	Calcium: Calcium supports healthy blood pressure by regulating vascular smooth muscle cell contractility and modulating peripheral vascular resistance* — the resistance in the circulatory system that creates blood pressure.10 Magnesium: The combined intake of magnesium and potassium coupled with reduced sodium intake has been found to be effective in maintaining normal blood pressure.11 Potassium: Potassium helps increase blood flow by promoting vasodilation.12 Low potassium intake is associated with high blood pressure.13
Other Compounds	Coenzyme Q10: CoQ10 is an important antioxidant for the cardiovascular system. Several studies have established the role of CoQ10 in supporting heart health.14,15,16 Clinical trials also show the beneficial effect of CoQ10 in maintaining normal blood pressure.17   Quercetin: Quercetin is a flavonoid that displays cardioprotective effects.*18 It helps maintain normal blood pressure by enhancing endothelial function and by down-regulating the activity of angiotensin-converting enzyme — a key component in blood pressure regulation.19 L-Arginine: An amino acid that enhances endothelial function and helps maintain normal blood pressure. 20  R-Lipoic Acid: A natural antioxidant that enhances vasodilation through nitric oxide mediation, resulting in improved endothelial function, helping to maintain normal blood pressure.21

Why do Certain Blood Pressure Support Supplements Work Better than Others?

Not all nutritional supplements are formulated alike. The efficacy of a blood pressure support supplement depends on the absorption and bioavailability (ability to be used where needed by the body) of its nutrients. Nutrients such as curcumin, quercetin, coenzyme Q10, and L-arginine display poor natural absorption owing to several factors including higher molecular weight (larger molecules) poor permeability (poor absorption through the gut wall), early degradation in the stomach (broken down by stomach acid and other digestive enzymes), and rapid metabolism (quickly transformed into a different molecule by the liver). On the other hand, supplements formulated with advanced delivery systems display better absorption than their natural counterparts. 

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Tesseract’s Advanced Blood Pressure Support Supplement Formulations

Tesseract Medical Research has developed a wide range of advanced blood pressure support supplements that promote cardiovascular health.* Tesseract’s innovative supplement formulations contain potent botanical extracts that have been conventionally difficult to absorb. The proprietary CyLoc® – DexKey® nutrient delivery nanotechnology addresses the bioavailability challenges of active nutrients, thus achieving targeted delivery and unprecedented absorption.* The following Tesseract formulations are among the best blood pressure support supplements available over the counter.*  

• CoQ10 Pro®: This solubility-enhanced CoQ10 formulation supports normal heart function and healthy blood pressure.*   
• QuerciSorb SR®: This hypoallergenic quercetin formulation is available in a sustained-release format to provide consistent and effective cardiovascular support: promoting vasodilation and a healthy blood pressure.*  
• NOX Flo SR®: Engineered for optimal circulatory function, NOX Flo SR contains the clinically validated rutinosides Hesperidin 2S and Diosmin citrus flavonoids. It also contains Citrulline, Coenzyme Q10, and R-lipoic acid, which enhance nitric oxide (NO) synthesis and improve NO-dependent endothelial function and vasodilation.*

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FAQs: Frequently Asked Questions 

Are there side effects to taking a blood pressure support supplement?

The safety profiles of most nutrients in blood pressure support supplements are well-established, and minimal adverse side effects have been reported. However, it is always recommended to consult your health-care provider before including any new nutritional supplement in your diet. 

Can I take a blood pressure support supplement with a prescription medicine?

Adverse interactions may exist between certain blood pressure medications and blood pressure support supplements. In addition, limited data is available on the prolonged use of these supplements or their effects on pregnant or breastfeeding women. Therefore, you should consult with your health-care provider before taking a blood pressure support supplement with your prescription medications.   

What are the features of an advanced blood pressure support supplement?

When considering an advanced blood pressure support supplement, you should always look for the following features:

1. Optimal absorption: Formulations with advanced nutrient delivery systems enhance the absorbability  of the supplement’s nutrients, resulting in optimal bioavailability to the tissues and organs.  
2. Targeted delivery: Targeted delivery of the active nutrients at the desired point in the intestinal tract enables the controlled release and maximum absorption of the nutrient molecules.  
3. Micro-dosing: Micro-dosing refers to achieving the desired health benefits of an active nutrient in lower doses than previously required, thus allowing for multiple nutrients to be highly efficacious in a single capsule.  

Tesseract’s supplement formulations have all these features, thereby achieving optimal bioavailability of each  nutrient,  helping to maintain a healthy blood pressure.*

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Citations:

¹Whelton SP, Chin A, Xin X, He J. Ann Intern Med. 2002;136(7):493-503. doi:10.7326/0003-4819-136-7-200204020-00006

²Jabbarzadeh Ganjeh B, Zeraattalab-Motlagh S, Jayedi A, et al. Hypertens Res. 2024;47(2):385-398. doi:10.1038/s41440-023-01467-9

³Bacon SL, et al. Sports Medicine (Auckland, N.Z.) vol. 34,5 (2004): 307-316. doi:10.2165/00007256-200434050-00003

⁴Spence JD, Barnett PA, Linden W, Ramsden V, Taenzer P. Canadian Hypertension Society, Canadian Coalition for High Blood Pressure Prevention and Control, Laboratory Centre for Disease Control at Health Canada, Heart and Stroke Foundation of Canada. CMAJ. 1999;160(9 Suppl):S46-S50.

⁵Appel LJ, Brands MW, Daniels SR, et al. Hypertension. 2006;47(2):296-308. doi:10.1161/01.HYP.0000202568.01167.B6

⁶Primatesta P, Falaschetti E, Gupta S, Marmot MG, Poulter NR. Hypertension. 2001;37(2):187-193. doi:10.1161/01.hyp.37.2.187

⁷Kirsch M, de Groot H. J Biol Chem. 2000;275(22):16702-16708. doi:10.1074/jbc.M909228199

⁸Czernichow S, Blacher J, Hercberg S. Curr Hypertens Rep. 2004;6(1):27-30. doi:10.1007/s11906-004-0007-7

⁹Boshtam M, et al. International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition vol. 72,5 (2002):309-314. doi:10.1024/0300-9831.72.5.309

¹⁰Kim Mi-H, et al. Nutrition Research and Practice vol. 6,5 (2012):421-428. doi:10.4162/nrp.2012.6.5.421

¹¹Houston M. Journal of Clinical Hypertension (Greenwich, Conn.) vol. 13,11 (2011):843-847. doi:10.1111/j.1751-7176.2011.00538.x

¹²Haddy FJ, Vanhoutte PM, Feletou M. Am J Physiol Regul Integr Comp Physiol. 2006;290(3):R546-R552. doi:10.1152/ajpregu.00491.2005

¹³Castro H, Raij L. Semin Nephrol. 2013;33(3):277-289. doi:10.1016/j.semnephrol.2013.04.008

¹⁴Mortensen SA, Rosenfeldt F, Kumar A, et al. JACC Heart Fail. 2014;2(6):641-649. doi:10.1016/j.jchf.2014.06.008

¹⁵Yang YK, Wang LP, Chen L, et al. Clin Chim Acta. 2015;450:83-89. doi:10.1016/j.cca.2015.08.002

¹⁶Martelli A, Testai L, Colletti A, Cicero AFG. Antioxidants (Basel). 2020;9(4):341. Published 2020 Apr 22. doi:10.3390/antiox9040341

¹⁷Zhao D, Liang Y, Dai S, et al. Adv Nutr. 2022;13(6):2180-2194. doi:10.1093/advances/nmac100

¹⁸Patel RV, Mistry BM, Shinde SK, Syed R, Singh V, Shin HS. Eur J Med Chem. 2018;155:889-904. doi:10.1016/j.ejmech.2018.06.053

¹⁹Larson AJ, et al. Pharmaceuticals (Basel, Switzerland) vol. 3,1:237-250. 19 Jan. 2010, doi:10.3390/ph3010237

²⁰Dong JY, Qin LQ, Zhang Z, et al. Am Heart J. 2011;162(6):959-965. doi:10.1016/j.ahj.2011.09.012

²¹Vasdev S, et al. Journal of Hypertension vol. 18,5 (2000):567-573. doi:10.1097/00004872-200018050-00009

Oxidative stress is an underlying cause of several adverse cardiovascular conditions. When there is an imbalance between reactive oxygen species (ROS) and the body’s antioxidant defenses, this imbalance can cause damage to cellular macromolecules, including DNA, lipids, and proteins, which can eventually result in cell dysfunction and even cell death.* 

Increased ROS negatively impacts cardiovascular health by:

• Lowering nitric oxide availability, which can lead to vasoconstriction and impaired blood* flow¹.
• Causing arterial hypertension, which can lead to increased strain on the heart and blood vessels².
• Negatively influencing myocardial calcium handling, which can affect the heart’s contractility and rhythm³. 
• Causing plaque formation, leading to an increased risk of a cardiovascular event⁴. 

Fortunately, our bodies have several natural enzymatic and non-enzymatic antioxidants that counter ROS and oxidative stress. In addition, specific vitamins, minerals, and compounds such as endocannabinoids can also mitigate oxidative stress in cardiac cells. 

Get answers to common questions about the best heart health supplements, including how they support healthy heart function and why you should select an advanced supplement formulation to include in your wellness routine. Use the links below to jump ahead to a topic of interest.

Factors Affecting Heart Health	Heart Health and Diet
Best Heart Health Supplements — An Overview	Advanced Heart Health Supplements to Include in Your Wellness Routine

Factors Affecting Heart Health

Your heart health can be adversely impacted by several factors, including: 

• Health conditions: such as elevated blood pressure, imbalanced cholesterol levels, increased blood glucose levels, and poor weight management⁵.* 

Elevated blood pressure increases strain on the heart muscle,  arteries and other blood vessels which can negatively affect the heart and other major organs of the body, including the brain and kidneys. 

Imbalanced cholesterol levels, especially elevated LDL cholesterol can lead to a buildup of plaque in arteries, increasing the potential risks of heart attack or stroke⁶.* 

Increased blood glucose levels can, over time, damage blood vessels and nerves, which can compromise heart function. 

Poor weight management can contribute to the development of high blood pressure and high glucose levels that negatively affect heart health⁷. *

• Lifestyle:  Diets high in trans fat, saturated fat, and cholesterol are associated with plaque buildup in arteries, increasing cardiovascular risk. Excessive salt intake may elevate blood pressure, while heavy alcohol use and tobacco products are also linked to heart disease⁸*. Additionally, a sedentary lifestyle with minimal physical activity can lead to higher blood pressure, elevated blood glucose, and increased cholesterol levels. 

• Other factors: A family history of heart disease can significantly increase the risk of unhealthy heart conditions in an individual. The risk of heart disease also increases with age. 

Heart Health and Diet

A healthy diet can help keep your heart healthy. A heart-healthy eating plan focuses on fruits, vegetables, and whole grains, as well as fat-free and low-fat dairy products. The following are popular diet plans aimed at improving heart health:

• Dietary Approaches to Stop Hypertension (DASH): This is a flexible and balanced eating plan focusing on daily and weekly nutritional goals. The DASH plan recommends the intake of: 

• Fruits, vegetables, and whole grains
• Fat-free and low-fat dairy products, poultry, beans, nuts, fish, and vegetable oils

The DASH diet recommends limiting the intake of sugar-sweetened food and beverages and foods high in saturated fats, such as full-fat dairy products and fatty meats. 

• Mediterranean diet: This diet is based on the traditional cuisines of the countries that border the Mediterranean Sea. It is mostly plant-based, which means meals are built around vegetables, fruits, nuts, herbs, beans, and whole grains. The diet recommends a limited intake of red meat and foods with added sugar. 

Antioxidants and micronutrients, including vitamins and minerals such as folic acid, vitamins C and E, selenium, copper, manganese, and zinc, are involved in pathways that mitigate oxidative damage and help maintain normal inflammatory responses in cardiac tissues and cells. The following table highlights several macro- and micronutrients that should be included in a diet to promote heart health. 

Best Heart Health Nutrients
Nutrient	Cardiovascular benefits
Omega-3 fatty acids	Omega-3 fatty acids, the key constituent of fish oil supplements, help maintain the normal inflammatory response in cardiac cells.9 Omega-3 fatty acids enhance endothelial function by promoting the release of nitric oxide from endothelial cells.10  It has been found that omega-3 fatty acids help lower serum levels of triglycerides, enhance flow-mediated arterial dilation, and promote the heart’s mechanical function.11
Folate	The naturally occurring form of vitamin B9, aka folate, is associated with healthy vascular reactivity, allowing for normal dilation and constriction of the blood vessels.12  Folate acts as an essential co-factor in homocysteine-methionine metabolism. An elevated homocysteine level is associated with plaque buildup in arteries.13
Vitamin D	A low blood level of vitamin D can increase the risk of adverse cardiovascular conditions.6  The vitamin D receptor is expressed in cells throughout the vascular system. Vitamin D plays a role in inhibiting vascular smooth muscle proliferation and vascular calcification.7  Vitamin D helps regulate blood pressure volume and glucose metabolism, limiting adverse inflammatory responses in the cardiovascular system.8,9
Potassium	Both a low or a high potassium level is linked to an irregular heartbeat.10  Potassium also helps maintain normal blood pressure levels.11
Magnesium	Magnesium activates the adenosine triphosphatase (ATPase) class of enzymes, which is essential for cell membrane functioning. A magnesium deficiency is associated with less polarized membrane potential, which can cause irregular heartbeat.12  Magnesium is a critical co-factor for the healthy functioning of the cardiac mitochondria (the cellular organelles responsible for producing the energy needed for cardiac muscular contraction and relaxation).13  Magnesium protects against potassium loss in the cardiac mitochondria, which is  critical for maintaining a healthy heart rate and rhythm.14

Best Heart Health Supplements: An Overview

Heart health supplement formulations that contain active nutrients, such as coenzyme Q10, quercetin, citrulline, R-lipoic acid, and anandamide, support cardiovascular wellness by addressing potential nutritional gaps.. 

Active Nutrients in Heart Health Supplements
Anandamide	Endocannabinoids, such as anandamide and 2-arachidonoylglycerol, are synthesized from membrane phospholipids in cardiac tissues. The endocannabinoids exert their cardioprotective effects1 by — Acting as a stress response system.*  Inhibiting plaque buildup in arterial walls.*  Relaxing the coronary and other arteries to decrease cardiac exertion.*
Coenzyme Q10	As an endogenous antioxidant that has its highest concentration in the heart, CoQ10 promotes heart health by2 — Lowering oxidative stress and mitochondrial dysfunction.*  Helping to maintain healthy levels of total cholesterol and low-density lipoprotein (LDL) levels.*  Enhancing endothelial function and limiting vascular stiffness.*
Quercetin	Quercetin, a flavonoid, exerts antioxidant effects and helps maintain the body’s natural inflammatory response.* Quercetin supports healthy heart function through3 — Inhibiting LDL oxidation in endothelial cells in arteries.*   Up-regulating the cell signaling pathways to inhibit oxidation of low-density lipoprotein (LDL).*  Helping to maintain normal blood pressure levels.*
Citrulline	The amino acid L-citrulline, found naturally in high concentrations in watermelon, exerts cardioprotective effects through4 — Enhancing endogenous synthesis of L-arginine and nitric oxide (NO) to help enhance vasodilation and maintain healthy blood pressure.*
R-Lipoic Acid	A natural antioxidant synthesized in the mitochondria of the liver and other tissues, lipoic acid plays a critical role in metabolism.* Lipoic acid promotes heart health through5 — Regulating cellular oxidation and limiting oxidative stress on cardiac cells.* Scavenging reactive oxygen species (ROS) and regenerating other antioxidants, including glutathione and vitamins E and C.*

Advanced Heart Health Supplements to Include in Your Diet

The poor natural absorption and bioavailability of many nutrients can impair their efficacy as ingredients in heart health supplements. Tesseract Medical Research optimizes the solubility of these active nutrients through its proprietary CyLoc® – DexKey® nutrient delivery nanotechnology. 

The following are some of the best heart health supplements developed by Tesseract Medical Research that achieve optimal therapeutic benefit of active nutrients for healthy heart function *

• AnaQuell®: This formulation contains anandamide and L-citrulline as active nutrients to promote a healthy response to stress and anxiety (non-GAD).* L-citrulline, by enhancing NO production, promotes cardiovascular health.* 

• CoQ10 Pro®: This formulation stands out among commercially available CoQ10 supplements because it enhances the solubility, absorption, and targeted delivery of CoQ10 molecules.* CoQ10 Pro promotes cardiovascular health and counters muscle pain, a common side effect of taking a cholesterol lowering prescription medication .* 

• NOX Flo SR®: This proprietary blend – of Diosmin citrus flavonoids, Citrulline, Hesperidin 2S rutinosides, CoEnzyme Q10, and R-Lipoic Acid – enhances the synthesis of nitric oxide (NO) and promotes NO-dependent endothelial function and vasodilation.* 

• QuerciSorb®: This proprietary quercetin complex helps maintain healthy blood pressure, down-regulates exaggerated immune responses, inhibits LDL cholesterol oxidation, and supports optimal heart functions.*

Tesseract’s proprietary nutrient delivery technology protects active nutrients from breaking down during their transit through the gastrointestinal tract and enables their targeted delivery in the body. The optimal absorption and bioavailability of active nutrients help achieve their benefits as heart health supplements. 

References:

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Article Summary:

• Vitamins, minerals, and specific botanicals support healthy immune function and strengthen the body’s defense system.*
  
  
• Certain compounds, such as zinc and quercetin, have naturally poor absorption, which can negatively impact the efficacy of immune supplement formulations.
  
  
• Tesseract’s proprietary nutrient delivery nanotechnology enhances the solubility and absorption of nutrient molecules for improved bioaccessibility for the immune system .*

The immune system is critical in protecting the body against pathogens (bacteria, parasites, viruses, and fungi), harmful pollutants, unwanted cellular changes and undesirable cellular growth that can adversely impact various body functions. The immune system, which is vital to the overall functioning of your body, requires the regular intake of adequate amounts of vitamins, minerals, and specific plant-derived compounds that exert antioxidant and immune-supporting effects.

Below, we discuss some of the best immune supplements, their benefits, and why you should include an advanced immune supplement formulation with your diet.  

Best Immune Supplements — An Overview

If you do not receive an adequate amount of specific vitamins and minerals through your regular diet, then it can compromise your immune function. A deficiency of certain vitamins and minerals has been linked to altered immune responses.¹ The following table highlights some of the best immune supplements — vitamins C and D, zinc, and quercetin — that should be in your diet, either in the form of food or as supplements. 

Some of the Best Immune Supplements to Support Your Health

Vitamin C: Vitamin C is one of the most critical micronutrients for supporting immune function.* White blood cells (key components of the immune system) rely on vitamin C to carry out their immune function as they accumulate vitamin C up to 100 times greater than that of the surrounding plasma (the liquid part of the blood).2  Vitamin C supports most aspects of immune function, including innate and adaptive immune functions.3  As an antioxidant, vitamin C protects immune cells from reactive oxygen species (ROS) produced during an immune response.4

Vitamin D: Vitamin D inhibits B-cell proliferation, differentiation, and immunoglobulin secretion, thereby decreasing the production of harmful inflammatory cytokines and adverse immune responses.5

Zinc:  Zinc is involved in regulating pathways in both innate and adaptive immune responses.6 Zinc protects the natural tissue barriers in the body (such as the cells lining the respiratory tract) and maintains the function of the immune and antioxidant systems.7  Zinc acts as an antioxidant by limiting oxidative stress and the production of inflammatory cytokines.8

Quercetin: Quercetin, a flavonoid derived from various plants, is an antioxidant that modulates various cell signaling pathways to limit the production of pro-inflammatory cytokines.9  Quercetin exerts a stabilizing effect on mast cells, a type of immune cell that releases histamine  (a signaling chemical that triggers adverse allergic responses).10  Quercetin helps maintain a balance between immune cells, particularly T-helper cells (Th1/Th2), thereby promoting a healthy immune response.11  Quercetin down-regulates adverse immune responses by inhibiting the production of leukotriene — an inflammatory mediator that activates immune cells.12

It is worth noting that because high amounts of immune supplements can cause side effects, you should always consult with your healthcare provider before including an immune supplement in your diet. 

But what are the best immune supplement formulations available over the counter? To promote healthy immune function, you should consider an advanced immune supplement with enhanced absorption and bioaccessibility.  

Including An Advanced Immune Supplement in Your Diet

Tesseract Medical Research has developed various nutritional supplements that support healthy immune function. QuerciSorb Immunophore SR® is a unique quercetin supplement formulated for optimal solubility and absorption. The formulation contains some of the best immuno-supportive nutrients — vitamins C and D, zinc, and quercetin for effective immune support.* 

The challenge with most immune-enhancing nutrients, such as zinc and quercetin, is they are not well-absorbed naturally. Tesseract’s groundbreaking CyLoc® – DexKey® nutrient delivery nanotechnology enables optimal absorption of active nutrients through the gut wall. The CyLoc® technology encases nutrient molecules, maintaining their integrity during the transit through the stomach. The accompanying DexKey® reactors release each molecule at the desired point in the intestinal tract for maximum absorption. 

Additionally, QuerciSorb Immunophore SR’s nutrients are delivered in a sustained-release format to support healthy immune function all day.* These features of Tesseract’s supplement formulation make it one of the best commercially available immune supplements.

Citations:

_¹Gombart, Adrian F et al. Nutrients vol. 12,1 236. 16 Jan. 2020, doi:10.3390/nu12010236

²Moore A, Deepesh K. Cureus vol. 15,1 e33740. 13 Jan. 2023, doi:10.7759/cureus.33740

³Carr AC, Maggini S. Nutrients. 2017;9(11):1211. Published 2017 Nov 3. doi:10.3390/nu9111211

⁴Kesarwani P, Murali AK, Al-Khami AA, Mehrotra S. Antioxid Redox Signal. 2013;18(12):1497-1534. doi:10.1089/ars.2011.4073

⁵Aranow C. Journal of Investigative Medicine: the official publication of the American Federation for Clinical Research vol. 59,6 (2011):881-886. doi:10.2310/JIM.0b013e31821b8755

⁶Prasad AS. Molecular Medicine (Cambridge, Mass.) vol. 14,5-6 (2008):353-357. doi:10.2119/2008-00033.Prasad

⁷Luan, Rumei et al. European journal of clinical nutrition vol. 77,4 (2023): 427-435. doi:10.1038/s41430-022-01191-6

⁸Jarosz, Magdalena et al. Inflammopharmacology vol. 25,1 (2017): 11-24. doi:10.1007/s10787-017-0309-4

⁹Ahn, Hye In et al. Journal of microbiology and biotechnology vol. 33,4 (2023): 430-440. doi:10.4014/jmb.2208.08034

¹⁰Li Y, et al. Nutrients vol. 8,3 167. 15 Mar. 2016, doi:10.3390/nu8030167

¹¹Tanaka, Yoshihito et al. Medicines (Basel, Switzerland) vol. 7,8 46. 30 Jul. 2020, doi:10.3390/medicines7080046

¹²Jafarinia, Morteza et al. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology vol. 16 36. 14 May. 2020, doi:10.1186/s13223-020-00434-0

Article Summary:

• Quercetin promotes various health functions, including the heart, kidneys, gastrointestinal system, immune function, and the neurological system.*
  
  
• The poor natural bioavailability and absorption of quercetin are a significant hindrance to its efficacy as an antioxidant and immunomodulatory agent.*
  
  
• Tesseract’s groundbreaking CyLoc® – DexKey® nutrient delivery nanotechnology addresses quercetin’s solubility and absorption challenges, making its use a therapeutic reality.  

As a polyphenol compound, quercetin displays antioxidant properties and protects against oxidative stress.* The immunomodulatory properties of quercetin help maintain the body’s natural inflammatory responses to mitigate adverse allergic reactions.* These properties of quercetin are crucial in supporting various health functions, including the heart, kidneys, gastrointestinal system, immune function, and others.* 

Although quercetin is abundantly present in multiple fruits and vegetables, free quercetin is poorly absorbed and has limited bioavailability, so it is  often recommended to include a quercetin supplement in your diet. Supplemental quercetin formulations typically use different delivery systems to overcome the solubility and absorption challenges. However, before incorporating a quercetin supplement into your diet, you should understand the benefits of  quercetin and how it supports various health functions.   

The Benefits of Quercetin — An Overview

Quercetin is derived from the Latin word ‘Quercetum’ which means oak forest. Although the body does not make quercetin, it plays a critical role in the peroxidation of lipids and platelet aggregation. The following table highlights quercetin’s benefits and how it can promote optimal health.*

Therapeutic Benefits of Quercetin
Health Function	Potential Benefits
Cardiovascular Health*	Quercetin modulates cell signaling pathways to inhibit the oxidation of low-density lipoprotein (LDL).*  Research1 shows that a regular daily intake of 500 mg of quercetin helps maintain normal blood pressure levels.* Quercetin also helps maintain healthy arteries by inhibiting the expression of adhesion molecules in human aortic endothelial cells.*
Immune Health*	Quercetin inhibits immune cells from releasing histamines — the body’s chemicals that trigger allergic reactions.*  Quercetin helps reduce the production of the proinflammatory cytokines that are involved in the up-regulation of inflammatory reactions.* Quercetin helps maintain the balance between the beneficial activities of T-helper 1 and T-helper 2 cells (Th1/Th2 balance).*
Neurological Health*	The lipophilic nature of quercetin helps it pass through the blood-brain barrier and function as a neuroprotective agent.*  Quercetin helps reduce lipid peroxidation and limits the oxidative damage to neurons.* In aging individuals, quercetin helps delay the onset of neurodegeneration.*
Gastrointestinal Health*	Quercetin helps maintain normal inflammatory responses in the gastrointestinal tract.* Several studies suggest that quercetin modulates gut microbial diversity, promotes the proliferation of beneficial bacteria, and suppresses the presence of pathogens.*
Renal Health*	Several studies demonstrate that quercetin protect kidneys by alleviating renal toxicity.* Quercetin helps maintain normal renal function by limiting the accumulation of senescent cells in the kidneys.*  Acting as an antioxidant, quercetin inhibits oxidative stress by scavenging toxins and limiting renal injury.*

The therapeutic role of quercetin and its safety profile is well established. However, you should consider including an advanced quercetin supplement formulation in your diet that resolves the poor solubility and absorption of this important nutrient.   

Including An Advanced Quercetin Supplement in Your Diet

Tesseract Medical Research has developed an innovative quercetin supplement formulation that supports cardiovascular health and immune function.* QuerciSorb® features the proprietary CyLoc® – DexKey® nutrient delivery nanotechnology, which is engineered to ensure the optimal absorption of quercetin and its rapid delivery throughout the intestinal tract. The CyLoc® technology encases quercetin molecules in a dextrin fiber matrix, thereby creating nano-sized particles that are easily absorbed. The accompanying DexKey® technology breaks the dextrin fiber cage at the desired release point in the intestinal tract for maximum absorption and efficacy. 

Tesseract’s ‘Three Pillar Approach’ ensures unprecedented absorption of quercetin while masking its bitterness. Enhanced absorption of the active nutrient enables micro-dosing — using less quercetin than previously required to achieve a potent and rapid physiological response.* With QuerciSorb®, quercetin’s cardioprotective and immuno-supportive benefits are unlocked to support your overall health.* 

Citations

1Serban M-C, et al. Effects of quercetin on blood pressure: A systematic review and meta-analysis of randomized controlled trials. Journal of the American Heart Association vol. 5,7 e002713. 12 Jul. 2016, doi:10.1161/JAHA.115.002713

2Feng J, et al. Quercetin alleviates intestinal inflammation and improves intestinal functions via modulating gut microbiota composition in LPS-challenged laying hens. Poultry science vol. 102,3 (2023): 102433. doi:10.1016/j.psj.2022.102433