Article Summary:
- The long-term adverse effects of standard allergy medications have led affected individuals to seek out natural alternatives.
- Quercetin’s antioxidant and immunomodulatory properties can help manage allergy symptoms.*
- Tesseract’s innovative quercetin supplement formulation utilizes proprietary nutrient delivery nanotechnology to optimize quercetin’s bioavailability.
What is an Allergy?
An allergy is an adverse reaction or exaggerated response of the body’s immune system to foreign substances that are not usually harmful, such as environmental allergens, including pollen, dust mites, specific food items, medications, or insect bites/stings. Allergic reactions can vary in severity, from mild reactions, such as a runny nose and sneezing, to severe reactions, such as hives, shortness of breath, and swelling of the lips, tongue, and/or airway.
What Happens in an Allergic Reaction?
An allergic reaction is triggered by the activation of the body’s mast cells and basophils (a type of white blood cell). These cells release signaling chemicals, including histamine, that generate allergy symptoms. The standard approach to addressing an allergic reaction is to block the effects of histamine through prescription or over-the-counter medications, called antihistamines.
However, these medications are associated with adverse side effects, including drowsiness, dry mouth, and blurred vision. Additionally, prolonged use has been linked to the adverse impacts of multiple physiological systems, particularly the nervous, cardiovascular, and gastrointestinal systems.
Quercetin, a flavonoid abundant in fruits and vegetables, has emerged as a natural alternative to help manage allergy symptoms. This blog post explains the potential of quercetin for allergy support and why you should consider adding an advanced quercetin supplement to your allergy care routine.
Quercetin for Allergy Support
Quercetin is well known for its antioxidant activity—it scavenges free radicals to protect cellular components from the damaging effects of oxidative stress.* Quercetin also displays immunomodulatory effects, including:
- Stimulating a healthy immune response by maintaining the equilibrium between two types of T-helper cells in the immune system.*
- Inhibiting histamine release*
- Down-regulating the production of pro-inflammatory cytokines, the signaling molecules that trigger or heighten imbalanced inflammatory responses*
Extensive research has explored the potential benefits of quercetin for allergy support. The following table lists several research studies that highlight the beneficial effects of quercetin for allergy support.
| Quercetin for Allergy Support | |
|---|---|
| Inhibiting mast cell activation* | Quercetin inhibits mast cell activation by inhibiting calcium influx, prostaglandins, and leukotrienes.*4 |
| Decreasing IgE-mediated food allergies | In an animal study, quercetin limited adverse peanut-induced allergic reactions.*5 |
| Inhibiting histamine release* | By stabilizing the cell membranes of mast cells, quercetin inhibits the production and release of histamine.*6 |
In addition to quercetin, other potential alternative therapies can address allergy symptoms, such as disodium cromoglycate, commonly known as cromolyn. Cromolyn is considered a “mast cell stabilizer” because it works by inhibiting the release of cytokines from mast cells. However, clinical studies indicate that quercetin is more effective than cromolyn in down-regulating pro-inflammatory cytokines, making quercetin a more promising candidate as an effective mast cell inhibitor.*7
Quercetin’s poor natural absorption and bioavailability impacts its efficacy as a nutritional supplement. Various approaches have been explored to enhance quercetin’s solubility, including nutrient-delivery nanotechnology, which has shown optimal absorption of quercetin through targeted delivery8.*
Including An Advanced Quercetin Supplement for Allergy Support
QuerciSorb® Immuphore SR, developed by Tesseract Medical Research, is an innovative nutritional supplement formulated with a highly soluble form of quercetin that supports healthy immune function.* Zinc (as zinc picolinate), vitamin C (as ascorbic acid), and vitamin D (as cholecalciferol) are also bioactive and bioavailable ingredients included in this hypoallergenic formulation that support the immune system’s optimal functioning.*
Tesseract’s proprietary CyLoc – DexKey® nutrient delivery technology achieves quercetin’s benefits for promoting optimal immune function.*
- Maintaining the integrity of the quercetin molecule: Tesseract’s CyLoc® technology surrounds each quercetin molecule to maintain its integrity during transit through the stomach.
- Targeted delivery of the quercetin molecule: Tesseract’s DexKey® reactors accompany each CyLoc® molecule, releasing quercetin molecules at the desired point in the gastrointestinal tract.
The resulting optimal absorption of each QuerciSorb molecule makes it a bioavailable reality, increasing the potential for quercetin for allergy support.*
The power of Tesseract supplements lies in enhancing palatability, maximizing solubility, absorption, and bioavailability, and micro-dosing a single or multiple nutrients in a single, highly effective capsule. Shop products on our website and learn more about how they support healthy immune function.*
References:
1Yanai K, et al. Curr Med Res Opin. 2012;28(4):623-642. doi:10.1185/03007995.2012.672405
2Miligkos M, et al. Pediatr Allergy Immunol. 2021;32(7):1533-1558. doi:10.1111/pai.13522
3Estelle F, Simons R. Ann Allergy Asthma Immunol. 1999;83(5):481-488. doi:10.1016/s1081-1206(10)62855-4
4Chirumbolo S. Iranian Journal of Allergy, Asthma, and Immunology vol. 10,2(2011):139-140.
5Shishehbor F, et al. Iranian Journal of Allergy, Asthma, and Immunology vol. 9,1(2010):27-34.
6Thornhill SM, Kelly AM. Alternative Medicine Review : A Journal of Clinical Therapeutics vol. 5,5(2000):448-454.
7Weng Z, et al. PloS One vol. 7,3(2012):e33805. doi:10.1371/journal.pone.0033805
8Altemimi, Ammar B et al. Nutrients vol. 16,5 636. 25 Feb. 2024, doi:10.3390/nu16050636
