Article Summary:
- The presence of CB1 and CB2 cannabinoid receptors throughout the body allows more widespread beneficial effects of anandamide.
- The immense therapeutic potential of anandamide has led to its use in supporting mental health and overall well-being, including memory, sleep, and appetite.*
- Anandamide in nutritional supplement form can help support a healthy response to mild anxiety (not generalized anxiety disorder – GAD) and stress.*
Our body’s endocannabinoid system (ECS) has immense untapped therapeutic potential, and anandamide is an integral part of that system. Often called the ‘bliss molecule,’ anandamide supports the optimal functioning of a wide range of processes throughout the nervous, cardiovascular, immune, renal, and gastrointestinal systems.* Although the signaling pathways through which anandamide works are not yet fully understood, clinical studies have established its positive role in maintaining a stable internal environment, or homeostasis.*
Below, we discuss some common anandamide uses to support mental and physical health and well-being.*
Anandamide Uses: An Overview
You might be wondering how anandamide imparts such widespread beneficial effects throughout the body. Endocannabinoids, like anandamide and 2-Archidonoylglycerol, express themselves when they bind to cannabinoid receptors, CB1 and CB2. These two receptors are present throughout the body, located predominantly in the cells of the nervous and immune systems. It is the ubiquity of the body’s two primary cannabinoid receptors that help transmit the beneficial effects of anandamide to multiple organs and systems.*
Anandamide’s uses for various therapeutic applications can be linked to how anandamide benefits body functions. Anandamide is known to support mental health, including memory, sleep, and appetite.* The following table highlights some common uses for anandamide based on current research.
| Short-Term Memory* | The pharmacological elevation of anandamide has been found1 to alter the neurophysiology in the hippocampus, thereby impacting the short-term memory. | |
| Inducing Sleep* | In studies2, anandamide has been found to enhance extracellular levels of adenosine that plays a key role in sleep-wake regulation.* | |
| Regulating Emotions | Research3 suggests the therapeutic role of the endocannabinoid system and anandamide in benefiting emotion and stress responses.* | |
| Dilating Blood Vessels* | Anandamide appears to induce4 vasorelaxation — the widening of blood vessels, particularly pulmonary arteries, indicating a potential use for maintaining healthy cardiovascular function.* | |
| Regulating Appetite* | Anandamide has been found5 to initiate and modulate positive appetitive behavior in rats and humans.* | |
Although your body naturally produces anandamide, certain health conditions can inhibit its sufficient production and therefore its ability to help maintain homeostasis. Excessive enzyme activity — such as fatty acid amide hydrolase (FAAH) — has been found to aggravate the degradation of the bliss molecule. A suboptimal anandamide level might adversely affect the entire body, especially compromising a person’s ability to adapt to stress-related environments.*
It is possible to stimulate the body’s natural production of anandamide by consuming anandamide-rich foods, including cacao nibs, dark chocolate, black truffles, meat, fish, seafood, eggs, and certain herbs and spices like oregano, black pepper, cloves, etc. Ingesting anandamide in the form of a nutritional supplement is another convenient way to enhance the anandamide levels.
Using an Anandamide Supplement to Support Your Overall Health and Well-Being*
AnaQuell®, a proprietary nutritional supplement formulation developed by Tesseract Medical Research, contains anandamide and L-citrulline to beneficially impact the body’s response to stress and mild (non-GAD) anxiety. L-citrulline is a natural precursor of L-arginine and is a critical component for nitric oxide production. AnaQuell’s innovative formula brings the best of both ingredients — the beneficial effects of anandamide in supporting good mental health and enhancing blood flow, as well as nutrient delivery to the brain through citrulline.*
The ground-breaking CyLoc® – DexKey® nano-molecular nutrient delivery technology further ensures the delivery of anandamide molecules through the gut wall for maximum absorption and bioavailability. The CyLoc® technology encases each molecule of the active ingredients to protect them from early degradation. The DexKey® technology releases the active ingredient molecules at the desired point in the intestinal tract for optimal absorption and enhanced therapeutic efficiency in modulating responses to stress and mild (non-GAD) anxiety.*
AnaQuell® is available as both a quick-release (QR) formula for an immediate physiological response, and as sustained release (SR) formula, for prolonged benefits during situations causing stress or mild (non-GAD) anxiety.*
The power of Tesseract supplements lies in enhancing palatability, maximizing bioavailability and absorption, and micro-dosing multiple nutrients in a single, highly effective capsule. Shop products on our website and learn more about how they can help support neurological health.*
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Citations:
1Goonawardena, Anushka V, et al. Neuropharmacology vol. 61,5-6 (2011): 1016-25. doi:10.1016/j.neuropharm.2011.07.003
2Murillo-Rodríguez, E, et al. Brain Research vol. 812,1-2 (1998): 270-4. doi:10.1016/s0006-8993(98)00969-x
3Marco, EM, Viveros MP. Mini reviews in medicinal chemistry vol. 9,12 (2009): 1407-15. doi:10.2174/138955709789957468
4Giménez M, Margarita V, et al. Therapeutic advances in cardiovascular disease vol. 12,7 (2018): 177-190. doi:10.1177/1753944718773690
5Jamshidi, N, and Taylor, DA. British Journal of Pharmacology vol. 134,6 (2001): 1151-4. doi:10.1038/sj.bjp.0704379
