(Note: The term ‘anxiety’ used in this article only refers to non-General Anxiety Disorder anxiety and does not promote supplement products that address any anxiety disorders. Please consult your healthcare provider before including these supplements in your diet.)
Article Summary:
- Multiple social and environmental factors can contribute to stress and anxiety, including nutrient deficiencies that can impact brain and gut health.
- Nutritional supplements are not a replacement for a balanced diet, but they can help fill nutrient gaps that may ease stress and anxiety.
- Tesseract’s innovative supplement formulations utilize proprietary nutrient delivery nanotechnology to promote optimal neurological and gastrointestinal health.
Stress and anxiety are the occasional queasy feelings of worry or fear that come from dealing with the daily rigors and ups and downs of life. This type of stress or anxiety is different from the severe or persistent anxiety that can adversely impact an individual’s mental well-being and overall health.
Nutritional supplements, such as anandamide, promote the healthy functioning of the body’s endocannabinoid system (ECS), which in turn supports a healthy response to stress and anxiety1. Additionally, gut health supplements and antioxidants can help maintain a healthy intestinal microbiome, which can indirectly help alleviate occasional feelings of stress and anxiety2.
This blog post highlights several supplements that can help adults navigate the stress of daily life while promoting both neurological and gastrointestinal health.
Anxiety Supplements for Adults: An Overview
What causes stress and anxiety? The exact factors causing stress and anxiety are not fully understood. Various social and environmental factors are certainly potential causes of occasional feelings of stress and anxiety. While nutritional supplements are not a replacement for a well-balanced diet, nutritional supplements may help address nutrient deficiencies, which can result in improved brain and gut health–thus helping to alleviate occasional stress and anxiety..
The body’s endocannabinoid system regulates an individual’s emotions, behavior, mood, and stress responses. The endocannabinoid system is the central integrator linking the perception of external and internal stimuli to specific behavioral outcomes, such as fear, stress, and anxiety. In addition to the ECS system, gut health and oxidative stress have also been attributed to influencing responses to fear, stress, and anxiety.
The following table highlights the relationship between anxiety, endocannabinoid signaling, gut health, and oxidative stress.
| Correlation between Anxiety, Endocannabinoid System, Gut Health and Oxidative Stress | ||
|---|---|---|
| Stress, anxiety, and endocannabinoid signaling | The human body produces two important endocannabinoids: anandamide and 2-arachidonoyl glycerol (2-AG). Enhanced anandamide signaling can alleviate stress and help manage the behavioral signs of anxiety.*3 |
|
| Stress, anxiety, and gut health | Current evidence supports a functional link between the gut and brain, with significant implications for mood, cognition, and mental health4. Imbalances in the gut microbiome (dysbiosis) can contribute to functional gastrointestinal disruptions. These disruptions are mechanistically linked to stress and anxiety through the gut-brain axis5. Short-chain fatty acids, such as butyric acid, help stabilize the gut microbiome, thus promoting better neurological health6. |
|
| Stress, anxiety, and oxidative stress | Oxidative stress is the imbalance between the body’s production of reactive oxygen species (or free radicals) and the ability of the body’s defense mechanism to detoxify these free radicals. The gene expression involved in antioxidative metabolism is closely associated with anxiety-related phenotypes, suggesting that oxidative stress may play a role in triggering stress, anxiety, and emotional distress7. Glutathione, the body’s master antioxidant, helps modulate oxidative stress and supports optimal neurological functions8. |
|
When considering the efficacy of nutritional supplements such as butyric acid, and glutathione to better manage stress and anxiety levels, it is also worth noting that these compounds have naturally low bioavailability. Advanced supplement formulations utilize innovative nutrient delivery technology for enhanced absorption.
Selecting the Best Anxiety Supplements
Tesseract Medical Research, a pioneer in advanced supplement manufacturing, has developed a wide range of stress and anxiety supplements. Tesseract’s proprietary CyLoc® – DexKey® nutrient delivery nanotechnology optimizes the solubility and absorption of the active nutrients in Tesseract supplements. The CyLoc® technology surrounds each nutrient molecule in a dextrin fiber matrix, and the accompanying DexKey® reactors release the molecules at the most desirable location in the intestinal tract.
Tesseract’s innovative smart delivery system enables unprecedented absorption of active nutrients, making these formulations the best choice among the various stress and anxiety supplements on the market. The following table highlights several stress and anxiety supplement formulations developed by Tesseract Medical Research.
| Stress and Anxiety Supplements for Adults | ||
|---|---|---|
| AnaQuell® | This revolutionary and hypoallergenic formulation is developed for enhanced anandamide absorption. AnaQuell® contains anandamide and L-citrulline for promoting a healthy response to stress, mood changes, mild (non-GAD) anxiety, and emotional upset.* Anandamide exerts an inhibitory effect on mild anxiety9. L-citrulline enhances blood flow and the accompanying nutrient delivery to the brain, thereby beneficially influencing the body’s response to stress, mild anxiety, and emotional upset10. |
|
| ProButyrate® | The proprietary complex contains natural butyric acid to promote gut health. Tesseract’s nutrient delivery system overcomes the palatability, bioavailability, and absorption challenges associated with butyric acid. ProButyrate helps maintain a healthy inflammatory response in the gut, thus supporting gastrointestinal and neurological health.* The advanced formulation makes obsolete the conventional method of butyrate supplementation, such as sodium butyrate enemas or oral ingestion of butyrate mineral salts. |
|
| SafeCell® | The formulation contains an acetylated form of glutathione. The body’s ‘master antioxidant’ is traditionally a difficult-to-absorb molecule through oral administration. Tesseract’s nutrient delivery technology enables targeted delivery of glutathione molecules for optimal absorption. SafeCell supports the body’s natural detoxification pathways and neutralizes free radicals, thus promoting optimal neurological health.* |
|
All Tesseract formulations are developed using the highest-quality nutrients, advanced analytical techniques, and a well-designed quality control system and are manufactured following Good Manufacturing Practices (GMPs).
The power of Tesseract supplements lies in enhancing palatability, maximizing solubility, absorption, and bioavailability, and nano-dosing multiple nutrients in a single, highly effective capsule. Shop products on our website and learn more about how they support neurological health.*
References:
1Morena M, et al. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience vol. 39,7 (2019):1275-1292. doi:10.1523/JNEUROSCI.2251-18.2018
2Khan MT, et al. Mol Cell Endocrinol. 2025;607:112599. doi:10.1016/j.mce.2025.112599
3Cryan JF, et al. Physiol Rev. 2019;99(4):1877-2013. doi:10.1152/physrev.00018.2018
4Kalkan AE, et al. Nutrients. 2025;17(8):1305. Published 2025 Apr 9. doi:10.3390/nu17081305
5Hassan W, et al. Curr Neuropharmacol. 2014;12(2):120-139. doi:10.2174/1570159X11666131120232135
6Pizzorno, Joseph. “Glutathione!.” Integrative medicine (Encinitas, Calif.) vol. 13,1 (2014): 8-12.
7Scherma, Maria et al. Acta pharmacologica Sinica vol. 40,3 (2019): 309-323. doi:10.1038/s41401-018-0075-x
7Appleton J. Integrative Medicine (Encinitas, Calif.) vol. 17,4 (2018):28-32.
8Bouayed J, et al. Oxidative Medicine and Cellular Longevity vol. 2,2 (2009):63-67. doi:10.4161/oxim.2.2.7944
10Li, Aiqin et al. Journal of exercise science and fitness vol. 23,3 (2025): 222-228. doi:10.1016/j.jesf.2025.04.004
