Article Summary:

• A coenzyme Q10 supplement benefits several body functions, including heart health, skin health, reproductive health, and immune function.* 
• CoQ10’s naturally poor bioavailability and absorption hinder the efficacy of most CoQ10 supplements.  
• Tesseract Medical Research’s advanced CoQ10 formulation utilizes a proprietary nutrient delivery nanotechnology for unprecedented absorption of CoQ10.

Coenzyme Q10 nutritional supplements come in the form of chewable tablets, capsules, oral sprays, and liquid syrups. CoQ10 supplements contain either the fully oxidized ubiquinone (CoQ10) or fully reduced ubiquinol (CoQ10H2) form of coenzyme Q10. Notably, while some studies (cite) indicate that ubiquinol generally has a higher bioavailability and absorption than ubiquinone, especially in specific populations, another study (cite the original one mentioned in references already) suggests no significant difference between the bioavailability and absorption of ubiquinone and ubiquinol supplements. Ultimately, the findings of these studies highlight that results are inconclusive and research is still emerging on the best delivery methods of CoQ10 supplements.  

So, does your body need a CoQ10 supplement, particularly when CoQ10 is endogenously produced in the body? This lipid-soluble nutrient is critical in cellular energy production across the body’s tissues and organs.* Its concentration is particularly high in the organs that have high metabolism rates, such as the heart, liver, and kidneys. However, endogenous CoQ10 levels declinewith age, certain health conditions, and the use of specific medications. Supplemental CoQ10 may be beneficial in maintaining optimal CoQ10 levels, supporting overall cellular function and health.

This post discusses how a coenzyme Q10 supplement benefits various organs and why you should consider taking an advanced CoQ10 supplement for your health.  

What are the Coenzyme Q10 Supplement Benefits?

The benefits of taking a coenzyme Q10 supplement are attributable to the nutrient’s antioxidant and immunomodulatory properties.* CoQ10’s antioxidant effect helps neutralize reactive oxygen species (ROS), providing protection against oxidative stress. By lowering oxidative stress and protecting cellular components, including mitochondria, it indirectly supports the function (cite) of antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT). This contributes to an overall more effective antioxidant defense system.*  The immunomodulatory properties of CoQ10 also help maintain the body’s normal inflammatory responses.*

The following table highlights the many benefits of a coenzyme Q10 supplement for various health functions in the body.

Health Function	CoQ10 Benefits
Heart*	CoQ10 supplementation promotes good cardiovascular health by — Improving3 lipid profiles, significantly lowering serum triglyceride levels.* Protecting cardiac muscle tissues from vascular oxidative stress through enhanced activity of SOD.* Enhancing blood flow and maintaining optimal blood pressure by preserving nitric oxide levels.* Countering muscle cramping and soreness caused by statin intake.
Skin*	A CoQ10 supplement benefits skin health by —  Limiting oxidative stress4 in skin cells, particularly the dermis layer.* Maintaining cellular metabolism by enhancing the mitochondrial functioning of aging skin cells.*
Reproductive Health*	Cellular mitochondrial dysfunction and oxidative stress are underlying causes of the age-related decline in female reproductive potential. Research5 suggests CoQ10 supplementation protects reproductive health against oxidative stress by — Promoting the development of competent ovarian follicles.*  Restoring oocyte mitochondrial function.*  Influencing female hormonal levels; in particular, enhancing the production of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH).*
Immune Function*	A CoQ10 supplement promotes healthy immune function by — Up-regulating the intensive energy requirements of immune cells to function optimally.* Inhibiting6 inflammatory gene expression to help maintain the body’s natural inflammatory response.*

Although the benefits of taking a CoQ10 supplement are well-established, the naturally poor absorption of CoQ10 compromises the efficacy of most CoQ10 supplements. The high molecular weight of CoQ10, its unstable ubiquinol form, its insolubility in water, and its limited solubility in lipids are the primary factors that adversely affect its bioavailability and subsequent absorption. Studies indicate that a solubilized CoQ10 formulation with an advanced nutrient delivery system displays enhanced bioavailability compared to unformulated CoQ10⁷. 

Including An Advanced CoQ10 Supplement in Your Diet

To enhance CoQ10’s bioavailability and absorption, advanced CoQ10 supplement formulations utilize novel approaches, including microcapsules, nanoparticles, nano-liposomes, solid dispersion systems, and cyclodextrin inclusion compounds. Encasing CoQ10 molecules with cyclodextrins is particularly effective in enhancing solubility. 

CoQ10 Pro® is an advanced CoQ10 supplement developed by Tesseract Medical Research. CoQ10 Pro’s innovative formulation utilizes Tesseract’s proprietary CyLoc® – DexKey® nutrient delivery nanotechnology for optimal absorption of CoQ10 molecules in the intestinal tract. Tesseract’s CyLoc® technology encases individual CoQ10 molecules in its smart delivery system. The accompanying DexKey® reactors release CoQ10 molecules at the desired point in the intestinal tract for maximum absorption. 

The resulting unprecedented absorption enables micro-dosing of the formulation — using the active nutrient in a lesser amount than previously required to increase circulating amounts of CoQ10 and to achieve coenzyme Q10 supplement benefits.*

¹Mantle D, Dybring A. Antioxidants (Basel, Switzerland) vol. 9,5 386. 5 May. 2020, doi:10.3390/antiox9050386

²Zhang Y, et al. Frontiers in Pharmacology vol. 13 936233. 14 Jul. 2022, doi:10.3389/fphar.2022.936233

³Sharifi N, et al. Current Pharmaceutical Design vol. 24,23 (2018):2729-2742. doi:10.2174/1381612824666180406104516

⁴Knott A, et al. BioFactors (Oxford, England) vol. 41,6 (2015):383-390. doi:10.1002/biof.1239

⁵Xu Y, et al. Reproductive Biology and Endocrinology: RB&E vol. 16,1 29. 27 Mar. 2018, doi:10.1186/s12958-018-0343-0

⁶Mantle D, et al. Antioxidants (Basel, Switzerland) vol. 10,5 759. 11 May. 2021, doi:10.3390/antiox10050759

⁷Sood, Brittany, et al. StatPearls – NCBI Bookshelf, 30 Jan. 2024, 

Article Summary:

• Glutathione is known as the body’s master antioxidant because it promotes detoxification, limits oxidative stress, and provides multiple other health benefits.*
• Glutathione’s health benefits are hindered significantly because of its naturally poor bioavailability and absorption. 
• Tesseract Medical Research’s proprietary nutrient delivery nanotechnology results in the optimal bioavailability and absorption of glutathione, helping to realize its beneficial effects. 

Glutathione has been a buzzword for quite some time, particularly in the beauty industry, because of its role in promoting skin health. However, the body’s so-called ‘master antioxidant’ has several other vital health benefits. This superior molecule is present in almost every cell in the body, and in a similar concentration as other important nutrients, such as potassium and glucose. The presence of glutathione in the body  is critical to mitigating oxidative stress by neutralizing and eliminating reactive oxygen species (ROS).*

Glutathione was first discovered in 1888 in extracts from yeast, egg whites, and animal tissue, albeit its specific role and function were not fully understood at that time. With advancements in biochemistry and molecular biology over time, its antioxidant properties have become more well-known to promote healthy aging because they inhibit the production of ROS, a phenomenon closely associated with aging. 

So, how does glutathione support various other body functions? Below, we discuss glutathione’s health benefits, its bioavailability and absorption challenges, and why you should include an advanced glutathione supplement in your healthcare regimen.

Glutathione Health Benefits: An Overview

Reduced glutathione (GSH) is a critical non-enzymatic antioxidant found in mammalian cells.* As a detoxifying agent and a primary antioxidant, glutathione supports the body’s natural innate detoxification pathways.* Although glutathione directly acts against free radicals and pro-oxidants, it also functions as a co-factor for multiple antioxidant and detoxification enzymes, such as the glutathione peroxidases, glutathione S-transferases, and glyoxalases.* 

Glutathione exerts its beneficial effects and protective functions through enzyme (glutathione reductase) reduction, conjugation with and elimination of xenobiotic compounds (heavy metals, toxins, electrophiles, and others), and interaction with other antioxidants (such as vitamin C) to recycle and replenish each other.* The following table highlights several glutathione health benefits that promote health functions. 

Glutathione Health Benefits
Health function	Benefits
Nervous system*	Glutathione plays a pivotal role in the functioning of the central nervous system, including1:  Modulating cell differentiation, proliferation, and cell death (apoptosis)* Neurotransmission*  Enzyme activation* Modulating the toxicity of metals by transporting them across cell membranes as GSH complexes*  Extracellular cysteine storage during protein synthesis.*
Gastrointestinal system*	Glutathione is abundantly distributed in the mucosal cells of the gastrointestinal tract and limits mucosal damage from oxidative stress2.*  A clinical study indicates that dietary supplementation of glutathione enhances the abundance and diversity of beneficial intestinal microbiota3,4,5.*
Immune function*	A delicately balanced intermediate level of glutathione is critical for the optimal functioning of the immune system’s lymphoid cells6.*  Glutathione helps regulate innate immunity at various levels by inhibiting adverse immune responses.*
Endocrine system*	Glutathione helps lower elevated liver enzymes and supports healthy hepatic metabolism.*
Skin and hair*	Glutathione’s antioxidant properties promote healthy skin and hair.*

Why do you need a glutathione supplement when it is abundantly present and endogenously produced in the body? Primarily, it’s because glutathione levels gradually deplete as we age. In addition, poor diet, an unhealthy lifestyle, and certain adverse health conditions can also negatively affect glutathione levels. Research studies indicate that consuming a glutathione supplement daily can enhance the body’s store of its master antioxidant.* 

Glutathione is well-known for being a difficult-to-absorb molecule that negatively impacts its associated health benefits. The rapid natural absorption of oral glutathione in the gastrointestinal tract and its subsequent poor bioavailability are the two major factors that hinder the efficacy of most glutathione supplements. What is needed is an advanced glutathione formulation that can enhance its bioavailability and subsequent absorption of the body’s master antioxidant. 

Including An Advanced Glutathione Supplement in Your Diet

Advanced glutathione supplementation is characterized by the following attributes:

• Targeted delivery: The delivery of glutathione molecules at the desired point in the intestinal tract enhances the bioavailability and subsequent absorption of glutathione. 

• Optimal absorption: A smart nutrient delivery system in an advanced supplement formulation will enable optimal absorption of the nutrient molecules.

• Micro-dosing: Unprecedented absorption of glutathione makes it possible to take in a lesser amount than previously required to achieve the desired health benefits. 

SafeCell® is an innovative glutathione supplement formulation developed by Tesseract Medical Research that solves glutathione’s bioavailability and absorption challenges. The acetylated glutathione formula utilizes Tesseract’s proprietary CyLoc® – DexKey® nutrient delivery technology to maximize glutathione’s absorption, thus achieving glutathione health benefits.

The CyLoc® technology encases glutathione molecules for safe passage through the stomach. The accompanying Dextrin® reactors release the active glutathione molecules at the desired point in the gastrointestinal tract to achieve their optimal absorption. The unique SafeCell formulation supports natural detoxification pathways, modulates oxidative stress, promotes the optimal functioning of other antioxidants, and supports optimal cellular and neurological function by crossing the blood-brain barrier.* The Tesseract Detoxification Solution helps you maintain optimal good health as you age.*

¹Iskusnykh IY, et al. Glutathione in brain disorders and aging. Molecules (Basel, Switzerland) vol. 27,1 324. 5 Jan. 2022, doi:10.3390/molecules27010324

²Loguercio C, Di Pierro M. The role of glutathione in the gastrointestinal tract: a review. Italian Journal of Gastroenterology and Hepatology vol. 31,5 (1999):401-407.

³Wang C, et al. Effects of glutathione on growth, intestinal antioxidant capacity, histology, gene expression, and microbiota of juvenile triploid Oncorhynchus mykiss.” Frontiers in Physiology vol. 12 784852. 29 Nov. 2021, doi:10.3389/fphys.2021.784852

⁴Xiong C, et al. Diet with optimal glutathione supplement improves growth, nonspecific immunity, intestinal microbiota, and antioxidant ability in Micropterus salmoides. J Fish Biol. 2024;104(5):1566-1578. 

⁵Gaike AH, et al. Effect of long-term oral glutathione supplementation on gut microbiome of type 2 diabetic individuals. FEMS Microbiol Lett. 2023;370:fnad116.

⁶Dröge W, Breitkreutz R. Glutathione and immune function. The Proceedings of the Nutrition Society vol. 59,4 (2000):595-600. doi:10.1017/s0029665100000847

Article Summary:

• Coenzyme Q10 (CoQ10) is typically poorly absorbed, adversely impacting the efficacy of most CoQ10 supplement formulations. 
• An advanced CoQ10 supplement should have enhanced bioavailability and absorption of CoQ10. 
• The proprietary nutrient delivery technology developed by Tesseract Medical Research enables targeted delivery of CoQ10 at the desired point in the intestinal tract to ensure optimal absorption.

Coenzyme Q10 (CoQ10) is an endogenous antioxidant that plays a critical role as an electron carrier in the mitochondrial electron transport chain, powering cellular energy production.*  CoQ10 modulates the mitochondrial permeability transition pore to influence cell signaling, cell growth, and apoptosis (cell death).* The beneficial effects of CoQ10 make it one of the most commonly used supplements for promoting optimal cardiovascular health.* 

However, coenzyme Q10’s poor bioavailability and absorption compromise the efficacy of most CoQ10 supplement formulations. So, what is the best coenzyme Q10 formulation that will ensure the optimal absorption of the active nutrient? Below, we discuss the key features of the best CoQ10 supplement formulation and why you should always consider an advanced formulation to support a healthy heart.* 

Key Features of the Best Coenzyme Q10 Supplements

Coenzyme Q10 has two forms: oxidized (ubiquinone) and reduced (ubiquinol). Both forms coexist and regenerate each other in the body through sequential redox reactions. This versatile molecule has been conventionally used as an oral supplement to enhance mitochondrial functions and to limit oxidative damage to cells by functioning as an antioxidant.* 

However, CoQ10’s poor intestinal absorption hinders its beneficial effects. One animal study ¹ indicated that only 3 percent of orally administered CoQ10 is absorbed. To combat this challenge, several approaches have been implemented to enhance CoQ10’s bioavailability and subsequent absorption. It has been observed that the bioavailability of CoQ10 supplement formulations depends on the matrix used to dissolve CoQ10 and the addition of nutrients, such as vitamin C, that help maintain CoQ10 in the reduced, more absorbable state. 

The following are several novel approaches to enhancing CoQ10’s solubility. 

• Liposomes: Nano-liposomes are long-circulating agents made of phospholipids or cholesterol. The lipid bilayers of nano-liposomes encapsulate CoQ10 molecules to enhance their bioavailability and prolong their circulating time in the blood.   

• Lipid-free nanoformulation: Biocompatible and biodegradable nanocarriers deliver small nutrient molecules, nucleic acids, etc. Lipid-based nanoparticles use surfactants to enhance the permeability and absorption of CoQ10 molecules. 

• Self-Nanoemulsifying Drug Delivery Systems: These are lipid-based mixtures that help improve the bioavailability of CoQ10 molecules by enhancing their dissolution in the gastrointestinal tract and enhancing their effectiveness throughout the body. 

• CoQ10-loaded oleogels: Oleogels are lipophilic in nature and are used to deliver water-insoluble molecules. CoQ10-loaded oleogels, a semi-solid gel with an oily matrix, make it easier to consume high doses of fat-soluble CoQ10, leading to more sustained blood levels over time and promoting patient compliance. 

• CoQ10 micellization: Micelles as nutrient delivery carriers offer higher stability. CoQ10 micelles enhance the nutrient’s solubility and cell membrane permeability to maintain high CoQ10 levels in the blood. 

• Water-soluble CoQ10: Encapsulating CoQ10 molecules in β-cyclodextrin inclusion complexes makes them soluble in aqueous environments. CoQ10/β-cyclodextrin complexes have been found² to significantly increase CoQ10’s solubility and enhance its gastrointestinal absorption.  

Based on the delivery systems, several novel CoQ10 supplement formulations have been developed. But how should you determine the best Coenzyme Q10 formulation for supplements? The following table highlights some key characteristics of the best CoQ10 formulations. 

Key Features of the Best Coenzyme Q10 Formulation
Advanced nutrient delivery system: The efficacy of advanced CoQ10 supplement formulations is significantly higher than unformulated CoQ10, owing to smart nutrient delivery systems that enable targeted delivery and sustained release of the CoQ10 molecules at the desired point in the intestinal tract.
Optimal absorption: Targeted delivery and slow release of CoQ10 molecules in the intestinal tract ensure optimal absorption. Research suggests that encasing CoQ10 with cyclodextrins enhances absorption and bioavailability, indicating that this delivery process is superior to oral formulations featuring uncomplexed CoQ10.
Micro-dosing: Unprecedented absorption of CoQ10 allows micro-dosing — consuming a lesser amount than previously required to achieve the desired beneficial health effects.

A coenzyme Q10 supplement formula with these features can be considered an advanced supplement for promoting optimal cardiovascular health. 

An Advanced CoQ10 Formulation Developed by Tesseract Medical Research

CoQ10 Pro® is a unique Coenzyme Q10 formulation developed by Tesseract Medical Research. The proprietary formulation uses the CyLoc® – DexKey® nutrient delivery system — a cyclodextrin technology that ensures optimal solubility and absorption of CoQ10 in microdoses. The CyLoc® technology encases each CoQ10 molecule to protect its integrity during transit through the stomach. The accompanying DexKey® reactors release the CoQ10 molecules at the desired point in the intestinal tract for maximum absorption. 

The targeted and sustained delivery of CoQ10 molecules to the heart and muscle tissues makes CoQ10 Pro® one of the best coenzyme Q10 formulations to support healthy cardiovascular function.* 

¹Bhagavan HN, Chopra RK. Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion vol. 7 Suppl (2007):S78-S88. doi:10.1016/j.mito.2007.03.003

²Pastor-Maldonado CJ, et al. Coenzyme Q10: Novel formulations and medical trends.” International Journal of Molecular Sciences vol. 21,22 8432. 10 Nov. 2020, doi:10.3390/ijms21228432

Article Summary:

• The best supplements for men promote optimal function of the heart, joints, immune system, endocrine system, gastrointestinal system, urinary system, and neurological system.*
• Most active nutrients in supplements have naturally poor absorption and bioavailability, which can undermine the efficacy of the supplement formulations.
• Tesseract’s proprietary nutrient delivery nanotechnology enhances the palatability, solubility, and absorption of active nutrients, making their benefits a therapeutic reality.

Men and women have different nutritional requirements. Although diet, exercise, and a healthy lifestyle are vital to a man’s health, you might not always obtain sufficient amounts of various essential vitamins, minerals, and other nutrients. Including one or more nutritional supplements in your regular diet can enable you to meet your health and wellness goals. 

The best supplements for men address top men’s health issues concerning the heart, joints, gastrointestinal system, endocrine system, urinary system, immune system, as well as mental health and well-being. Let’s look at the therapeutic benefits of key active nutrients on men’s health and examine why you should always consider advanced supplement formulations containing these nutrients and that are formulated for optimal absorption and efficacy.      

Best Supplements for Men’s Health: An Overview 

Almost two-thirds of U.S. adults take dietary supplements. It is estimated that 68 percent of adult males (ages 20 and over) use dietary supplements, and the usage increases with age. The most commonly reported reason for using dietary supplements is to enhance and maintain overall health and wellness. Research¹ suggests men are more likely to use supplements to promote heart health or to help maintain good cholesterol levels.

Best Supplements for Men
Active Nutrient	Therapeutic Benefits on Men’s Health
Coenzyme Q10	CoQ10 is an antioxidant that supports cardiovascular health and helps maintain healthy low-density lipoprotein (LDL) cholesterol levels.  CoQ10 mitigates exercise-induced oxidative stress and skeletal muscle injury, enhancing exercise performance.
Butyric Acid	Butyric acid — a short-chain fatty acid (SCFA), is vital for stabilizing the gut microbiome and supporting a healthy inflammatory response in the gastrointestinal tract.*  Butyric acid promotes healthy weight management, helps maintain healthy blood glucose levels, and enhances intestinal barrier function.*
Saw Palmetto	This bioactive compound modulates the unpleasant urological symptoms associated with an enlarged prostate gland.*
Glutathione	Glutathione, the body’s primary antioxidant and detoxifying agent, supports healthy immune function.* Glutathione down-regulates oxidative stress and its depletion is linked to several adverse health conditions associated with aging.*
Quercetin	Quercetin — the most abundant flavonoid in nature, is known for its cardio-protective and immuno-supportive properties.* Quercetin promotes testosterone synthesis and mitigates swelling of the prostate gland.*
Curcumin	Curcumin helps maintain the body’s normal inflammatory response and positively benefits joint health.* Curcumin and its metabolites promote a healthy gastrointestinal environment, optimal lipid profiles, and supports cardiovascular health.*
Anandamide	Anandamide, one of the body’s primary endocannabinoids, promotes cardiovascular health and supports a healthy response to stress and anxiety (non-General Anxiety Disorder).* Anandamide beneficially influences hormone signaling, stimulating a sense of happiness and mental well-being.*

It should be noted that most of these nutrients are difficult for the body to absorb due to their naturally low bioavailability. In addition, butyric acid and curcumin pose significant challenges to regimen compliance because of their poor palatability. Therefore, supplement formulations that enhance the  palatability, absorption, and bioavailability, of these nutrients help achieve their therapeutic benefits. 

Including Supplements in Your Diet

Tesseract Medical Research’s proprietary CyLoc® – DexKey® nutrient delivery nanotechnology enables unprecedented absorption of active nutrients, thereby enhancing their efficacy. The CyLoc® technology encases individual active nutrient molecules in its dextrin fiber matrix to maintain the integrity of the molecules as they transit through the stomach. The accompanying DexKey® rectors release molecules at the desired point in the intestinal tract to achieve maximum absorption. 

The following are some of the best supplements for men developed by Tesseract Medical Research:

• CoQ10 Pro®: Promotes cardiovascular health with optimal absorption of CoQ10 and addresses muscle soreness due to exercise or side effects of medications, such as statins.*

• ProButyrate®: Ensures palatability and optimal absorption of butyric acid through the gut wall to promote a balanced gut flora and a healthy inflammatory response in the gastrointestinal tract.*

• ProstaSorb^TM: Addresses the side effects of an enlarged prostate gland, including decreased urinary flow and volume, compression of the urethra and bladder, increased frequency of urination, and poor sleep patterns.*

• SafeCell®: The acetylated form of glutathione supports natural detoxification pathways, mitigates oxidative stress, and promotes healthy cellular, hepatic, and neurological functions.*

• QuerciSorb®: This hypoallergenic formulation provides antioxidant support, modulates exaggerated immune responses, supports healthy blood pressure through optimal vasodilation, and inhibits LDL cholesterol oxidation to promote cardiovascular health.*   

• TetraCumin®: Developed in both quick-release and 12-hour sustained-release forms, TetraCumin® helps maintain optimal lipid profiles, cardiovascular health, and an optimal gastrointestinal environment.*  

• AnaQuell®: Anandamide and L-citrulline positively influence the body’s response to stress and anxiousness, in addition to enhancing blood flow and nutrient delivery to the brain.*

Tesseract’s unique pharmacological approach, which combines proprietary science with the therapeutic potential of potent botanical extracts, differentiates our nutritional supplements from other brands in the health and wellness landscape. 

Citation:

¹Bailey RL, et al. JAMA internal medicine vol. 173,5 (2013): 355-361. doi:10.1001/jamainternmed.2013.2299

Article Summary:

• The best supplements for a woman are determined by her nutritional needs, which change with age.
• Active nutrients, such as curcumin, coenzyme Q10, glutathione, berberine, butyric acid, and anandamide, support multiple health functions in women.*
• Tesseract’s unique nutrient delivery nanotechnology ensures optimal absorption of a supplement’s active nutrients to help achieve their therapeutic effects.        

Various surveys indicate the usage of nutritional supplements among women is higher than among men, and supplement use is highest among women 60 and older. Some nutrients, such as folic acid, calcium, vitamin D, and vitamin B12, are critical for female health. Bioactive compounds, including curcumin, coenzyme Q10, berberine, and glutathione, also support several important female health functions. 

The best supplements for women contain active nutrients that promote joint health, immune function, heart health, gastrointestinal health, reproductive health, healthy skin and hair, and mental and emotional well-being.* Let’s look at the therapeutic benefits of these active nutrients and how they help maintain a woman’s overall health.   

Best Supplements for Women: An Overview

Although a balanced diet and exercise are always key to a healthy lifestyle, you might not get all of the nutrients your body requires through your diet, which is why supplements can help fill any nutritional gaps. For women, their dietary needs change with age, with some nutrients, such as folic acid, being required more during the childbearing years, whereas other nutrients, such as vitamin B12 and calcium, are required more during aging. 

The following table highlights several important nutrients and how their beneficial effects promote health functions in women. 

Best Supplements for Women
Active Nutrient	Therapeutic Effects on Women’s Health
Curcumin	Women are more likely to experience poor joint health that progresses with age. Curcumin promotes joint health, providing a healthy inflammatory response to periodic musculoskeletal and joint flare-ups.* The antioxidant properties of curcumin mitigate oxidative stress, which is considered the root cause of several female reproductive conditions.*
Coenzyme Q10	CoQ10 is mostly known for its therapeutic benefits on the heart and muscle tissues, thus promoting optimal cardiovascular health.* Clinical studies1 support the role of CoQ10 in promoting female reproductive health.*
Glutathione	Glutathione, as a master antioxidant, mitigates oxidative stress that influences the adverse signs of aging.* Glutathione promotes healthy skin and hair, as well as playing a role in maintaining hormonal balance in women.*
Berberine	Berberine intake is associated with lowering insulin resistance, maintaining optimal blood glucose levels, and supporting healthy weight management.* Berberine helps regulate menstrual patterns and ovulation rates, thus promoting good reproductive health in women.*
Butyric Acid	Butyric acid supplementation enhances gut health and balanced immune responses in the intestinal mucosal cells.* Animal research2 indicates the potential role of butyric acid in enhancing ovarian functions, thus supporting good reproductive health.*
Anandamide	This important endocannabinoid promotes a healthy response to mood changes, mild anxiety (non-General Anxiety Disorder), and stress.*

Although the therapeutic benefits of these active nutrients on women’s health are well-researched, the poor natural bioavailability and absorption of these compounds hinder their efficacy. When considering the best supplements for women, you should look for advanced supplement formulations that enhance the solubility and absorption of these nutrients.  

An Advanced Supplement Formulation for Women 

The proprietary CyLoc® – DexKey® nutrient delivery nanotechnology developed by Tesseract Medical Research encases the individual active nutrient molecules in Tesseract supplements in a dextrin fiber matrix to maintain their integrity as they transit through the stomach. The smart delivery system also masks the unpleasant taste or odor of nutrients such as turmeric, berberine, and butyric acid to make them more palatable and achieve regimen compliance. 

The accompanying DexKey® reactors release each active nutrient molecule at the desired point in the intestinal tract to achieve maximum absorption. The unprecedented absorption of active nutrients enables micro-dosing — using nutrients in lesser amounts than previously required to achieve the desired physiological outcomes. 

The following are several Tesseract nutritional supplements that support women’s health functions:

• TetraCumin®: Tetrahydrocurcumin, the most bioavailable form of curcumin, promotes musculoskeletal and immune health, in addition to promoting a healthy gastrointestinal environment and maintaining optimal lipid profiles.*

• CoQ10 Pro®: This Coenzyme Q10 supplement supports cardiovascular health and mitigates exercise-induced muscle soreness.* It also addresses the muscle aches and soreness associated with taking a statin medication.*

• SafeCell®: The acetylated form of oral glutathione in SafeCell supports natural detoxification pathways and mitigates oxidative stress, while also promoting the cellular functions that support healthy aging.*  

• BerberActiv®: Berberine supports gastrointestinal health, lipid metabolism, healthy weight management, as well as healthy liver and cardiovascular function.*

• ProButyrate®: This short-chain fatty acid formulation enhances the palatability and absorption of butyric acid to help maintain a healthy gut microbiome and a balanced inflammatory response in the gastrointestinal tract.*

• AnaQuell®: The unique combination of anandamide and L-citrulline positively influences the body’s response to stress and anxiety (non-GAD), thus promoting mental and emotional well-being.*

Note: Although the safety profiles of these nutrients are well-established, it is always recommended to consult your health-care provider before including a new nutritional supplement in your diet, especially if you are pregnant or breastfeeding.    

Citations:

¹Florou P, et al. Journal of assisted reproduction and genetics vol. 37,10 (2020): 2377-2387. doi:10.1007/s10815-020-01906-3

²Liu K, et al. Clinical epigenetics vol. 15,1 86. 13 May. 2023, doi:10.1186/s13148-023-01487-9

Updated on September 16, 2024

Are you considering including butyric acid supplements in your diet? Butyric acid has numerous health benefits, including promoting gastrointestinal and neurological health.* But when do you need a butyric acid supplement? What are the best butyric acid supplements? And are butyric acid supplements safe?

This article answers all these questions about this multi-functional molecule and why  taking an advanced butyric acid supplement may be beneficial. Use the links below to jump to specific topics about butyric acid and butyric acid supplements.

The Basics of Butyric Acid: An Overview

Butyric acid, or butyrate, is a short-chain fatty acid (SCFA) produced in the large intestine  when beneficial gut bacteria ferment dietary fiber. Butyric acid can also be consumed from plant oils, animal fats, and nutritional supplements. Butyric acid is a multi-functional molecule known for its distinctive strong odor and wide range of health benefits. 

Butyric acid’s health benefits are attributed to the following: 

• Epigenetic regulator: Epigenetic regulators are specific molecules that control the expression of certain genes. Butyric acid acts as an epigenetic regulator to inhibit DNA synthesis in cells exhibiting abnormal growth and regulates cell growth and division by inducing changes in gene expression¹.*
• Energy substrate: Butyric acid is the primary energy source for colon cells (colonocytes), contributing to 60-70 percent of their energy requirement².* 
• Transmembrane protein activator: Butyric acid activates several transmembrane proteins involved in multiple cell signaling pathways³.*

Why Might You Need A Butyric Acid Supplement?

Butyric acid naturally occurs in milk, hard cheese (such as parmesan), butter, cream, yogurt, fermented soy, pickled cucumber, and other foods. Additionally, plant products containing dietary fibers are a particularly good source of endogenous production of butyric acid through bacterial fermentation. A diet rich in legumes, whole grains, fruits and vegetables, nuts and seeds, and dairy products helps your body maintain an optimal butyric acid level. 

So, why do you need a butyric acid supplement? You should consider adding a butyric acid supplement to your diet when: 

1. A fiber-rich diet does not suit you.  Certain gastrointestinal conditions make digesting a large amount of fiber uncomfortable or even painful. Other gastrointestinal conditions can make it challenging to increase butyrate levels through dietary fiber intake alone. In addition, many consuming a Western diet find it difficult, if not impossible, to eat an adequate amount of fiber on a daily basis.

2. The gut microbiome fails to produce the necessary amount of butyrate. Individuals who have certain gastrointestinal disorders may have low butyric acid levels because the inflamed gastrointestinal mucosa cannot absorb any butyrate that is produced. Other conditions where dysbiosis (negative alterations in populations of gut microbes) is present, decrease the formation of butyric acid(4). Even with the recommended dietary fiber intake, your intestines might not produce the required amount of butyrate. 

Under such conditions, a butyric acid supplement can be a suitable alternative (or addition) to a fiber-rich diet. 

Raw Butyric Acid versus Butyric Acid Supplements

Conventional butyrate supplementation is achieved through oral ingestion of butyrate mineral salts or through the use of a sodium butyrate enema. However, when sodium butyrate salt comes in contact with moisture, it emits a strong, distinctive, and foul odor, making it difficult to ingest orally. On the other hand, a sodium butyrate enema is less preferred over oral supplements because it must be injected rectally under medical supervision. 

When considering a butyric acid supplement, it is worth noting that not all oral supplements are formulated alike. The following table highlights the differences between the palatability and absorption of raw butyric acid and butyric acid supplements.  

Comparison: Raw Butyric Acid versus Butyric Acid Supplement
	Raw Butyric Acid	Butyric Acid Supplements
Palatability	Highly pungent odor and acrid taste make it difficult to ingest.	Advanced supplement formulations make butyrate palatable.
Absorption	Quickly absorbed in the upper intestinal tract and rapidly eliminated from the body.	Encapsulated butyrate supplements enable targeted delivery of butyric acid molecules for enhanced absorption.*

Potential Benefits of Butyric Acid Supplements

The gut microbiome plays a critical role in the functioning of various organs. Researchers have found that butyric acid supplements can help enhance glutathione levels, which, in turn, can help limit oxidative damage to the gastrointestinal system and other organs⁵.* 

In addition to influencing intestinal health and oxidative stress, the gut microbiome has been linked to modulating cognition through the ‘gut-brain axis’, potentially regulating behavior, learning and memory⁶. 

The following table highlights how butyric acid supplementation can help promote gastrointestinal and neurological health. 

Benefits of Butyric Acid Supplements
Gastrointestinal System	The presence of butyric acid in the gut inhibits the growth of pathogenic (bad) bacteria, which negatively affect gut health and function7.* Butyric acid supplementation promotes gastrointestinal health by:   Addressing Oxidative Stress:  Research has  shown that butyrate can modulate the effects of oxidative stress in the colon8.*  Acting as an Intestinal Barrier: Butyrate stimulates the production of mucin, the glycoproteins (mucus) produced by colon cells that act as a protective internal coating9.*  Metabolic Regulation: Butyrate stimulates the colon to absorb sodium chloride (NaCl), a protective mechanism against dehydration9.* Immune Function: Butyric acid beneficially influences immune responses in intestinal mucosa by modulating the migration of immune cells, their adhesion, and cellular functions10.* Colonic motility: Butyric acid enhances colonic motility,the peristaltic motion of the intestine that allows for quick and easy passage of stool11.*
Neurological System	Butyrate has been shown to have beneficial effects on neurological health due to its neuroprotective effects and modulation of the gut-brain axis, supporting healthy cognitive function12.*

Future Explorations of Butyric Acid Benefits

The properties of butyric acid and its role in gastrointestinal and neurological health are well-established. In recent years, newer research is focusing on the previously unknown properties and health benefits of butyric acid. The following are some of the future explorations of butyric acid benefits:

• Butyric acid for weight management: The association between intestinal microflora and metabolic health has been recently established¹³. Butyrate exerts beneficial effects on cellular energy metabolism and intestinal homeostasis.* Low butyrate levels have been associated with several metabolic conditions, including blood glucose levels, insulin resistance, and weight gain¹⁴. Butyric acid supplementation has been found to promote healthy weight management¹⁵.*
• Butyric acid for heart health: Research studies show that butyric acid is absorbed into the portal vein, which can beneficially influence lipid metabolism, glucose homeostasis, and other critical metabolic processes.* Imbalance in the gut microbiota has been recognized as one of the factors involved in developing adverse cardiovascular conditions¹⁶. Butyric acid supplementation may exert cardioprotective effects by stabilizing microbial composition in the gut¹⁷.*   
• Butyric acid for kidney health: Butyric acid exerts immunomodulatory effects and influences the activity of regulatory T cells (Tregs) and T-helper cells to help maintain normal inflammatory responses.* Research on its role as a potential immunoregulatory agent to address conditions arising from renal injury is ongoing¹⁸. 

Frequently Asked Questions About Butyric Acid Supplements

The following are frequently asked questions about butyric acid supplements: 

What is the recommended amount of butyric acid intake in supplement form?

The recommended amount of butyric acid in currently available nutritional supplements is 150-300 mg/ day¹⁹.   

Are butyric acid supplements safe?

The safety profile of butyric acid is well-established. No toxicity or adverse side effects have been reported, and butyric acid supplements are well-tolerated, even when ingested in high amounts. 

Can I take a butyric acid supplement with a prescription medicine? 

It is always advised to consult with your health-care provider before including a butyric acid supplement in your diet or taking it with a prescription medicine and/or other nutritional supplements as interactions may exist.

How do I determine the best butyric acid supplement to support my health? 

The key features of the best butyric acid supplement are: 

• Enhanced absorption: Targeted delivery of butyric acid molecules at the desired point in the intestinal tract, which enables optimal absorption.
• Enhanced bioavailability: Optimal absorption translates to enhanced bioavailability of butyric acid molecules. 
• Enhanced palatability: Supplement formulations that successfully mask the unpalatable taste and odor of butyric acid result in better regimen compliance. 

ProButyrate® is an innovative butyric acid formulation developed by Tesseract Medical Research that enhances butyric acid’s absorption, bioavailability, and palatability. Tesseract’s proprietary CyLoc® – DexKey® nutrient delivery nanotechnology protects the integrity of the butyric acid molecules during transit through the stomach and enables their targeted delivery in the intestinal tract. The encapsulated butyrate molecules have enhanced palatability, making it easier to ingest orally. With improved bioavailability, ProButyrate® can help you realize the  health benefits of butyric acid.*  

Citations: 

¹Steliou K, et al. BioResearch Open Access vol. 1,4 (2012): 192-198. doi:10.1089/biores.2012.0223

²Donohoe DR, Garge N, Zhang X, et al. Cell Metab. 2011;13(5):517-526. doi:10.1016/j.cmet.2011.02.018

³Peng K, et al. Frontiers in Endocrinology vol. 14 1098881. 24 Feb. 2023, doi:10.3389/fendo.2023.1098881

⁴Amiri P, et al. Frontiers in Pharmacology vol. 12 837509. 2 Feb. 2022, doi:10.3389/fphar.2021.837509

⁵Chen Z, et al. Frontiers in Cell and Developmental Biology vol. 9 733308. 2 Nov. 2021, doi:10.3389/fcell.2021.733308

⁶Carabotti, Marilia et al. Annals of gastroenterology vol. 28,2 (2015): 203-209.

⁷Zhu, Li-Bin et al. World journal of clinical pediatrics vol. 10,5 84-92. 9 Sep. 2021, doi:10.5409/wjcp.v10.i5.84

⁸Canani, Roberto Berni et al. World journal of gastroenterology vol. 17,12 (2011): 1519-28. doi:10.3748/wjg.v17.i12.1519

⁹Zeissig S, Fromm A, Mankertz J, et al. Gastroenterology. 2007;132(1):236-248. doi:10.1053/j.gastro.2006.10.033

¹⁰Böcker U, Nebe T, Herweck F, et al. Clin Exp Immunol. 2003;131(1):53-60. doi:10.1046/j.1365-2249.2003.02056.x

¹¹Sui SJ, Tian ZB, Wang QC, et al. Eur Rev Med Pharmacol Sci. 2018;22(14):4730-4738. doi:10.26355/eurrev_201807_15533

¹²Alpino GCÁ, Pereira-Sol GA, Dias MME, Aguiar AS, Peluzio MDCG. Beneficial effects of butyrate on brain functions: A view of epigenetic. Crit Rev Food Sci Nutr. 2024;64(12):3961-3970. doi:10.1080/10408398.2022.2137776

¹³Portincasa P, Bonfrate L, Vacca M, et al. Int J Mol Sci. 2022;23(3):1105. Published 2022 Jan 20. doi:10.3390/ijms23031105

¹⁴Brahe LK, Astrup A, Larsen LH. Obes Rev. 2013;14(12):950-959. doi:10.1111/obr.12068

 ¹⁵Peng K, et al. Frontiers in Endocrinology vol. 14 1098881. 24 Feb. 2023, doi:10.3389/fendo.2023.1098881

¹⁶Amiri P, et al. Frontiers in Pharmacology vol. 12 837509. 2 Feb. 2022, doi:10.3389/fphar.2021.837509

¹⁷Aguilar EC, Leonel AJ, Teixeira LG, et al. Nutr Metab Cardiovasc Dis. 2014;24(6):606-613. doi:10.1016/j.numecd.2014.01.002

¹⁸Chen Z, et al. Frontiers in Cell and Developmental Biology vol. 9 733308. 2 Nov. 2021, doi:10.3389/fcell.2021.733308
¹⁹Peng K, et al. Butyrate and obesity: Current research status and future prospect. Frontiers in Endocrinology vol. 14 1098881. 24 Feb. 2023, doi:10.3389/fendo.2023.1098881

Article Summary:

• Vitamins B, C, and E, citrulline, coenzyme Q10, and lipoic acid are a few of the nutrients that promote healthy veins.*
• The poor bioavailability and absorption of these nutrients can adversely impact the efficacy of most vein health supplements.
• The proprietary nutrient delivery nanotechnology developed by Tesseract Medical Research achieves the optimal solubility of active nutrients, thus enhancing endothelial and vascular functions.*

Veins are blood vessels in the human body that play a critical role in blood circulation, facilitating the return of blood low in oxygen back to the lungs to reload with oxygen and, finally, to head back to the heart to be pumped again. Veins constitute a network of connecting tubes throughout the body, ranging in diameter from 1 mm to 2 cm. Healthy veins promote healthy blood circulation for optimal functioning of the body’s different organs.*

A balanced diet and an active lifestyle are integral to keeping your heart, blood, and blood vessels (arteries, arterioles, capillaries, venules, and veins) healthy. Vein health supplements can help fill nutritional gaps and promote cardiovascular health.* In this article, we discuss some key vein health supplements and why you should consider including an advanced vein health supplement formulation in your diet to support overall circulatory and vascular health.*

Vein Health Supplements: How They Promote Your Cardiovascular Health 

Your dietary choices significantly impact your vascular health. Food sources that are high in sodium, sugar, unhealthy fats, and low in fiber can compromise venous function¹. A balanced diet for vein health should consist of fruits and vegetables, fiber-rich foods, and foods containing omega-3 fatty acids and vitamin E. Hydration is also critical to maintaining vein health. The following table highlights some key nutrients that support vein health, and the food sources rich in those nutrients and their benefits. 

Vein Health Supplement Nutrients, Their Food Sources, and Benefits
1. Vitamin B (B1, B6, B12, Folic Acid)	B vitamins are water-soluble vitamins found in various foods, including fortified cereals, whole grains, lentils, bananas, liver, shellfish, and eggs.  Vitamin B1 promotes better blood circulation through endothelium-dependent vasodilation — the widening of arteries or veins2.   Vitamin B6 and B12 help limit instances of blood clot formation in veins.  Folic acid, too, enhances endothelium-dependent vasodilation in peripheral circulation.
2. Vitamin C	Citrus fruits, bell peppers, cherries, tomatoes, cruciferous vegetables, and white potatoes are rich in vitamin C.  Vitamin C is an antioxidant that helps protect vascular vessels from the harmful effects of oxidative stress3.
3. Vitamin E	Vitamin E, a fat-soluble vitamin, is found in various fruits, vegetables, nuts and seeds, and cooking oils, including wheat germ oil, sunflower seeds, soybean oil, pumpkin, red bell peppers, spinach, and avocado.  Vitamin E modulates molecular mechanisms, limiting blood clot formationwithin veins and arteries and maintaining a natural inflammatory response in blood vessels4.
4. Citrulline	Citrulline is an amino acid found in pumpkin, squash, cucumber, melons, and watermelon.  It enhances L-arginine and nitric oxide (NO) levels to increase blood flow and induce vasodilation5.*
5. Coenzyme Q10	CoQ10 is a fat-soluble compound synthesized in animal tissues. Food sources rich in CoQ10 include oily fish, organ meats, and whole grains.  CoQ10 acts as an antioxidant to resist aging and the dysfunction caused by oxidative stress in vascular endothelial cells6.*  CoQ10 supplementation has been found to alleviate various adverse health conditions associated with blood vessel dysfunction or insufficiencies.*
6. Lipoic Acid	Vegetables like broccoli, spinach, Brussels sprouts, tomato, red meat, and organ meats are rich in the naturally occuring compound, lipoic acid.  Lipoic acid enhances endothelial function by increasing the bioavailability of endothelium-derived NO and functioning as an antioxidant by limiting oxidative stress and adverse inflammatory reactions7.*

Although these nutrients can be obtained through diet, nutritional supplements are also a suitable alternative for supporting healthy veins.* 

Including An Advanced Vein Health Supplement in Your Diet 

NOX-FLO^TM is an advanced vein health supplement developed by Tesseract Medical Research. Its formula contains clinically validated rutinosides, Hesperidin 2S, and Diosmin citrus flavonoids, along with citrulline, Coenzyme Q10, and R-lipoic acid, for enhancing NO synthesis and NO-dependent endothelial function and vasodilation.* Its potent blend of nutrients is powered by Tesseract’s proprietary CyLoc® – DexKey® nutrient delivery nanotechnology for optimal bioavailability and absorption. 

This groundbreaking vein health supplement’s unprecedented absorption of active nutrients provides nutritional support to individuals experiencing compromised endothelial function and vascular insufficiencies.*

¹He J, Ma F, Yao J, et al. Dietary Effects on Chronic Venous Disease. Ann Vasc Surg. 2023;88:257-267. doi:10.1016/j.avsg.2022.06.015

²Arora S, et al. Thiamine (vitamin B1) improves endothelium-dependent vasodilatation in the presence of hyperglycemia. Annals of Vascular Surgery vol. 20,5 (2006):653-658. doi:10.1007/s10016-006-9055-6

³Ren J, et al. Vascular benefits of vitamin C supplementation against fine particulate air pollution in healthy adults: A double-blind randomised crossover trial. Ecotoxicology and Environmental Safety vol. 241 (2022): 113735. doi:10.1016/j.ecoenv.2022.113735

⁴Garg A, Lee JC-Y. Vitamin E: Where are we now in vascular diseases? Life (Basel, Switzerland) vol. 12,2 310. 18 Feb. 2022, doi:10.3390/life12020310

⁵Miyatake S, et al. Oral administration of l-citrulline alters the vascular delivery of substances to rat skeletal muscles. Biochemistry and Biophysics Reports vol. 28 101149. 8 Oct. 2021, doi:10.1016/j.bbrep.2021.101149

⁶Zozina VI, et al. Coenzyme Q10 in cardiovascular and metabolic eiseases: Current state of the problem. Current Cardiology Reviews vol. 14,3 (2018):164-174. doi:10.2174/1573403X14666180416115428
⁷Hajizadeh-Sharafabad F, Zahabi ES. Role of alpha-lipoic acid in vascular function: A systematic review of human intervention studies. Critical Reviews in Food Science and Nutrition vol. 62,11 (2022): 2928-2941. doi:10.1080/10408398.2020.1861425

Article Summary:

• Curcumin supplements are among the top-selling nutritional supplements in the United States.
  
• The efficacy of most curcumin supplements is adversely affected by poor natural bioavailability and absorption. 
  
• Tesseract’s advanced curcumin supplement formulation contains tetrahydrocurcumin, the most bioavailable form of curcumin, delivered through the proprietary CyLoc® – DexKey® nutrient delivery nanotechnology. 

Are you considering including a curcumin supplement in your diet? The yellow pigment extracted from the roots of the turmeric plant is well-known for its multiple health benefits. Although turmeric has been used in many cultures for culinary and food coloring purposes for centuries, more recently the biological activities of turmeric are being extensively studied to understand its beneficial health effects. 

Beneficial health properties of curcumin include musculoskeletal system,  immune,  cardiovascular, gut, and liver support.* Research studies indicate that curcumin can help manage several health-related conditions triggered by oxidative stress and adverse immune responses¹.* 

This article discusses the key benefits of curcumin supplements, how curcumin can support different systems in the body, and why you should include an advanced curcumin supplement in your diet for optimal health benefits. 

How A Curcumin Supplement Benefits You 

Curcumin’s benefits are attributable to its antioxidant and immunomodulatory properties². Curcumin possesses a neutralizing effect on free radicals (agents of oxidative stress) making it a powerful antioxidant.* It helps to mitigate  adverse immune reactions by decreasing  several cell signaling pathways, including the nuclear factor NF-κB pathway³.* The following table highlights how a curcumin supplement can benefit your health and wellness. 

Curcumin Supplement Benefits You Should Know About
Musculoskeletal system*	Curcumin supplements may help mitigate exercise-induced inflammation and muscle soreness by promoting a healthy inflammatory response4.* This effect is critical in enhancing recovery from periodic musculoskeletal and joint flare-ups.*
Immune function*	Curcumin supplements enhance the body’s natural defense capacity by up-regulating the activity of various immune cells (macrophages, dendritic cells, B, T, and natural killer cells)5. Curcumin has also been shown to support a healthy inflammatory response6.*
Heart health*	Curcumin has been shown to positively affect several risk factors associated with cardiovascular conditions as well as limit oxidative stress to cardiac cells7.*
Gastrointestinal health*	Recent research indicates that curcumin may positively affect the gut microbiome by favoring the growth of beneficial bacterial strains8.* Curcumin also helps promote a healthy inflammatory response in the intestinal tract9.*
Liver health*	Curcumin supplements limit oxidative stress in the liver by inhibiting lipid peroxidation, free radical formation, and DNA damage10.* Curcumin interacts with various molecular and cellular mechanisms to exert hepatoprotective effects.*

Curcumin has   low toxicity, with minimal adverse side effects reported¹¹. It is categorized by the U.S. FDA as a Generally Recognized As Safe (GRAS) nutrient. Although the health benefits of curcumin are well-established, it is always recommended to consult with your health-care provider before including a curcumin supplement in your diet. 

It should be noted that natural curcumin alone does not yield the associated health benefits because of its poor  absorption, poor bioavailability as well as rapid metabolism (elimination from the body). Adding other nutrients have been been shown to  enhance curcumin’s bioavailability. For example, piperine, the primary active component of black pepper, is known to significantly increase curcumin’s bioavailability¹². 

Innovative curcumin formulations have recently displayed better absorption than free, unformulated curcumin. However, not all  curcumin supplements are formulated the same. The poor absorption and bioavailability of curcumin continues to impact the efficacy of most new supplement formulations. Advanced curcumin formulations include various encapsulation techniques, including nanotechnology, in an effort to enhance the solubility of curcumin. 

Including An Advanced Curcumin Supplement in Your Diet

TetraCumin®, developed by Tesseract Medical Research, is an advanced curcumin supplement formulation consisting of tetrahydrocurcumin – the most bioavailable form of curcumin.* Although tetrahydrocurcumin displays physiological properties similar to curcumin, it is more stable and more easily absorbed through the gut wall¹³.* The proprietary CyLoc® – DexKey® nutrient delivery nanotechnology further optimizes the solubility and absorption of tetrahydrocurcumin to better achieve the health benefits of this innovative curcumin supplement. 

The CyLoc® technology encases individual tetrahydrocurcumin molecules to protect their integrity during their transit through the stomach. The accompanying DexKey® reactors release the CyLoc® molecules at the desired point in the intestinal tract for maximum absorption. 

The unprecedented absorption through this revolutionary delivery technology results in rapid physiological responses to enhance tetrahydrocurcumin’s many health-promoting benefits.* TetraCumin’s advanced formulation enables micro-dosing, making it possible to take the supplement in lesser amounts than previously required to achieve the desired beneficial effects.*

The power of Tesseract supplements lies in enhancing palatability, maximizing absorption and bioavailability, and micro-dosing multiple nutrients in a single, highly effective capsule. Shop products on our website and learn more about how they can support your immune health.* 

Citations:

¹Hewlings SJ, Kalman DS. Foods (Basel, Switzerland) vol. 6,10 92. 22 Oct. 2017, doi:10.3390/foods6100092

²Allegra A, et al. International Journal of Molecular Sciences vol. 23,23 14710. 25 Nov. 2022, doi:10.3390/ijms232314710

³Olivera, Anlys et al. International immunopharmacology vol. 12,2 (2012): 368-77. doi:10.1016/j.intimp.2011.12.009

⁴Fernández-Lázaro, Diego et al. Nutrients vol. 12,2 501. 15 Feb. 2020, doi:10.3390/nu12020501

⁵Farzaei MH, et al. Nutrients vol. 10,7 855. 1 Jul. 2018, doi:10.3390/nu10070855

⁶Peng, Ying et al. Drug design, development and therapy vol. 15 4503-4525. 2 Nov. 2021, doi:10.2147/DDDT.S327378

⁷Cox FF, et al. Cells vol. 11,3 342. 20 Jan. 2022, doi:10.3390/cells11030342

⁸Scazzocchio B, et al. Nutrients vol. 12,9 2499. 19 Aug. 2020, doi:10.3390/nu12092499

⁹Dulbecco, Pietro, and Vincenzo Savarino. World journal of gastroenterology vol. 19,48 (2013): 9256-70. doi:10.3748/wjg.v19.i48.9256

¹⁰Farzaei, Mohammad Hosein et al. Nutrients vol. 10,7 855. 1 Jul. 2018, doi:10.3390/nu10070855

¹¹Soleimani V, Sahebkar A, Hosseinzadeh H. Phytother Res. 2018;32(6):985-995. doi:10.1002/ptr.6054

¹²Stati G, Rossi F, Sancilio S, Basile M, Di Pietro R. Front Pharmacol. 2021;12:780330. Published 2021 Oct 29. doi:10.3389/fphar.2021.780330

¹³Maiti, Panchanan et al. Antioxidants (Basel, Switzerland) vol. 10,10 1592. 11 Oct. 2021, doi:10.3390/antiox10101592

Your mental health refers to your emotional, psychological, and social well-being and is integral to your overall health. Your mental health affects how you think, feel, act, and cope with the normal stresses and anxieties of life. So, it is critical to take care of your mental health through proper nutrition, adequate exercise and sleep, and stress management practices. 

Nutrition’s vital role in supporting mental health is gaining increasing awareness. In addition to food sources, nutritional supplements for supporting mental health can fill many nutritional gaps. So, what are the best mental health support supplements? Are cannabinoids good for your mental health? Are there mental health support supplement formulations? 

Get the answers to questions about the top mental health support supplements, including how they promote your emotional health, the role of endocannabinoids as mental health support supplements, and advanced supplement formulations. Use the links below to jump ahead to different topics on the page.

Neurological Health: An Overview	The Relationship Between Neurological and Gastrointestinal Health
Food Sources That Promote Your Neurological Health	Cannabinoids: Are They Good for You?
Anandamide: The Cannabinoid the Body Produces	Tesseract’s Advanced Mental Health Support Supplement Formulations
Frequently Asked Questions About Mental Health Support Supplements

Neurological Health: An Overview

Your neurological system is responsible for your intelligence, learning, memory, thoughts, sensations, emotions, perception, physical movement, and autonomic body functions.  Neurological health is defined as the healthy functioning of the brain, spinal cord and peripheral nervous system (the nerves). Mental health refers to the state of our emotional, psychological, and social well-being. It affects how we think, feel, and behave, and influences how we handle stress, relate to others, and make choices. Your mental health is largely dependent on the health of your nervous system in addition to your general physical health.

Emerging research highlights the relationship between nutrient imbalances and neurological conditions¹. There is also a growing body of evidence supporting the connection between nutrition and mental health. Several studies and reviews have highlighted the potential impact of diet on mood disorders, including depression and anxiety^2,3. Both macronutrients (carbohydrates, protein and fat) and micronutrients (vitamins, minerals and antioxidants) play a vital role in the proper functioning of the nervous system, promoting mental well-being. 

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The Relationship Between Neurological and Gastrointestinal Health

A growing body of evidence suggests that disturbances in the gut-brain axis (the communication system between the gut and the brain) can contribute to mental health disorders. We now know that the gastrointestinal tract is lined with trillions of beneficial microbes (bacteria, fungi, viruses and others) collectively known as the gut microbiome. These microbes do many beneficial things for us including digesting food, producing vitamins, regulating the immune system, protecting against harmful pathogens, metabolizing drugs, maintaining gut health, regulating metabolism and influencing mood and mental health⁴. Dysfunction in the gut microbiome has been associated with poor cognitive performance⁵. Conversely, certain neurological conditions can affect gut function and cause adverse inflammatory responses in the gastrointestinal environment⁶. Micronutrients as well as prebiotic and probiotic supplements have been shown to support a healthy gut microbiome,  indicating their potential beneficial role for promoting mental health^7,8.   

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Food Sources That Promote Your Neurological Health

Food sources rich in vitamins (folic acid, vitamin D), minerals (zinc and magnesium), poly-unsaturated fatty acids (Omega-3 fatty acids), amino acids (glycine, N-acetylcysteine), and probiotics (as well as postbiotics) are known to promote mental health. The following table highlights the food sources that promote good neurological health. 

Foods Promoting Brain Function
Vegetables and fruits	Vegetables and fruits contain kaempferol, a flavonoid with antioxidant and neuroprotective effects9.  Cruciferous, yellow, and green leafy vegetables, such as kale, cabbage, green beans, cucumber, squash, tomatoes, broccoli, and Brussels sprouts.  Fruits include berries (gooseberries, blackberries, raspberries, strawberries), apples, grapes, citrus fruits, peaches, and grapefruit.
Proteins	Meat, fish, seafood, and eggs are rich sources of arachidonic acid — an essential polyunsaturated fatty acid that displays immuno-modulating properties and plays a critical role in neurodevelopment10.
Spices and herbs	Spices, such as black pepper and long pepper, contain a novel plant compound guineensine, that helps maintain normal inflammatory responses in the nervous system11. Herbs like dill, chives, saffron, and tarragon contain kaempferol.
Beverages	Beverages like tea — particularly green and black Kenyan tea — also contain kaempferol.
Chocolates and Truffles	The mood-boosting effects of (unprocessed) chocolate are attributed to cacao beans or nibs, which contain various beneficial compounds, including anandamide (a cannabinoid neurotransmitter also produced by the body).  Truffles are underground mushrooms that contain endocannabinoid metabolic enzymes that enhance the endocannabinoid system (ECS) in our body (a system that regulates our neurotransmitters, immune function, metabolism, pain and sensory perception, and protection of the nervous system).
Probiotics & Postbiotics	Food rich in probiotics, like yogurt, cheese, and kombucha, support the growth of the beneficial bacteria in the gut microbiome, indirectly promoting  mental wellness.  Certain microbiome imbalance can lead to low levels of butyric acid, a short-chain fatty acid produced by certain bacteria in your gut when they break down fiber. Butyric acid plays an important role in keeping the gut healthy by providing energy to the cells lining the intestines and helping to maintain a strong barrier against harmful substances. Supplementation may be useful in conditions where levels are low. Postbiotic nutrients, such as butyric acid, support brain health by countering gastrointestinal disturbance caused by certain  microbiome imbalances.

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Cannabinoids: Are They Good for You?

Cannabinoids are a class of compounds with psychoactive properties (substances that can affect your mind, mood, emotions, or behavior) which exert an overall modulatory effect on the brain reward circuitry, thereby supporting mental and emotional health¹². Cannabinoids can be derived from plants, and some are produced by our bodies (referred to as ‘endocannabinoids’). Examples of plant-derived cannabinoids include Tetrahydrocannabinol (THC) and cannabidiol (CBD). Anandamide (AEA) and 2-arachidonoyl glycerol (2-AG) are the cannabinoids produced in the body. 

The plant-derived cannabinoid THC interacts directly with the endocannabinoid receptors (CB1 and CB2) to mimic the functions of endocannabinoids. CBD, on the other hand, works indirectly with CB1 receptors to enhance endogenous anandamide signaling. So, are plant-derived cannabinoids good for you?

It is worth noting that the use of THC or CBD products as nutritional supplements or food additives is much debated. In contrast, anandamide supplements are a suitable alternative to THC/CBD and are widely recognized as one of the top mental health support supplements for promoting brain health and overall well-being.

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Anandamide: The Cannabinoid Your Body Produces

Let’s understand what anandamide is before considering its beneficial effects. The endocannabinoid system (ECS) in our body consists of a group of neuro-modulatory lipids that influence emotional processing. The key components of the ECS are —

• Endocannabinoids: Anandamide (AEA) and 2-arachidonoyl glycerol (2-AG)

• Endocannabinoid receptors: Including CB1 and CB2 receptors

• Associated enzymes: Including fatty acid amide hydrolase (FAAH) and monoacylglycerol acid lipase (MGL)  

Chemically, anandamide is arachidonyl-ethanolamide (AEA), a lipid-based neurotransmitter that binds to the cannabinoid receptors in different regions of the body and brain. The following table highlights the potential benefits of anandamide on brain health. 

How Does Anandamide Promote Mental Health?

Anandamide binds to CB1 receptors that help induce dopamine release in the brain, resulting in a sense of temporary pleasure13. This endocannabinoid participates in maintaining serotonin levels, which beneficially influences stress-related behaviors14. Anandamide modulates vigilance states and benefits sleep cycles15,16. Anandamide supports the release of endorphins, thereby promoting a sense of well-being15.

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Tesseract’s Advanced Mental Health Support Supplement Formulations

Tesseract Medical Research’s AnaQuell^® is an innovative nutritional supplement formulation that supports the body’s natural response to stress.* The combination of anandamide and L-citrulline in the proprietary complex supports a healthy response to mood changes and mild non-GAD anxiety.* The addition of L-citrulline to the complex supports nitric oxide (NO) production, maintaining healthy blood flow and promoting cardiovascular health.*

AuRx® is a gold-standard medical food for ASD, featuring a stabilized butyric acid complex delivered in a palatable powder to ensure user compliance, especially in children. This hypoallergenic medical food supports healthy levels of butyric acid, promoting healthy behavior, language and emotional stability in ASD children.*

Tesseract’s proprietary and revolutionary CyLoc^® – DexKey^® technology enhances the solubility and absorption of active nutrients in the above two formulations to achieve their benefits. It is a nanomolecular nutrient delivery system that maintains the integrity of nutrient molecules during transit through the stomach, thereby enabling their targeted delivery at the desired point in the intestinal tract for optimal absorption. 

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FAQs: Frequently Asked Questions About Mental Health Support Supplements 

Why should you consider taking a mental health support supplement?

You should consider a mental health support supplement to:

1. Complement an inadequate diet or support low plasma levels of a specific nutrient to achieve the recommended nutrient intake. 
2. Fill nutritional gaps of specific nutrients lacking in a typical Western diet. 
3. Enhance the bioavailability and absorption of nutrients to achieve their health benefits. 

Are there side effects to taking a mental health support supplement?

Mental health support supplements are generally safe for oral intake. However, research shows that the overstimulation of CB1 receptors can disrupt the brain’s reward circuitry, resulting in unhealthy dietary patterns and subsequent weight gain. Hence, it is always recommended to consult with your healthcare provider before including a mental health support supplement in your diet. 

Can I take a mental health support supplement with a prescription medicine?

There may be an interaction between a mental health support supplement and a prescription medication. There is limited data on the use of these supplements with medications as well as limited data on prolonged intake of these supplements with prescription medications. Therefore, you should always consult with your healthcare provider before taking a mental health support supplement with a prescription medication.  

What are the features of an advanced mental health support supplement?

When considering an advanced mental health support supplement, you should look for the following features:

1. Optimal absorption: Formulations with advanced nutrient delivery systems enhance the bioavailability of active nutrients, resulting in optimal absorption.  

2. Targeted delivery: Targeted delivery of active nutrients at the desired point in the intestinal tract enables the controlled release of the nutrient molecules.  

3. Micro-dosing: Micro-dosing refers to achieving the desired health benefits of an active nutrient in lower doses than previously required. It allows for multiple nutrients to be highly efficacious in a single capsule.  

Tesseract’s mental health support supplement formulations have these three features to achieve the benefits of active nutrients promoting emotional and mental well-being.*

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¹Tsalamandris G, et al. The role of nutrition in neurological disorders. Nutrients vol. 15,22 4713. 7 Nov. 2023, doi:10.3390/nu15224713

²Carabotti M, et al. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Annals of Gastroenterology vol. 28,2 (2015):203-209.

³Scherma M, et al. Brain activity of anandamide: a rewarding bliss? Acta Pharmacologica Sinica vol. 40,3 (2019):309-323. doi:10.1038/s41401-018-0075-x

⁴Ameri A, et al. Effects of the endogenous cannabinoid, anandamide, on neuronal activity in rat hippocampal slices. British Journal of Pharmacology vol. 126,8 (1999):1831-1839. doi:10.1038/sj.bjp.0702478

⁵Tooley, Katie Louise. “Effects of the Human Gut Microbiota on Cognitive Performance, Brain Structure and Function: A Narrative Review.” Nutrients vol. 12,10 3009. 30 Sep. 2020, doi:10.3390/nu12103009

⁶Cannon AR, Anderson LJ, Galicia K, et al. TRAUMATIC BRAIN INJURY-INDUCED INFLAMMATION AND GASTROINTESTINAL MOTILITY DYSFUNCTION. Shock. 2023;59(4):621-626. doi:10.1097/SHK.0000000000002082

⁷Hemarajata, Peera, and James Versalovic. “Effects of probiotics on gut microbiota: mechanisms of intestinal immunomodulation and neuromodulation.” Therapeutic advances in gastroenterology vol. 6,1 (2013): 39-51. doi:10.1177/1756283X12459294

⁸Madabushi, Jayakrishna S et al. “Gut Biome and Mental Health: Do Probiotics Work?.” Cureus vol. 15,6 e40293. 12 Jun. 2023, doi:10.7759/cureus.40293

⁹Calderón-Montaño JM, Burgos-Morón E, Pérez-Guerrero C, López-Lázaro M. A review on the dietary flavonoid kaempferol. Mini Rev Med Chem. 2011;11(4):298-344. doi:10.2174/138955711795305335

¹⁰Hadley KB, Ryan AS, Forsyth S, Gautier S, Salem N Jr. The Essentiality of Arachidonic Acid in Infant Development. Nutrients. 2016;8(4):216. Published 2016 Apr 12. doi:10.3390/nu8040216

¹¹Reynoso-Moreno I, Najar-Guerrero I, Escareño N, Flores-Soto ME, Gertsch J, Viveros-Paredes JM. An Endocannabinoid Uptake Inhibitor from Black Pepper Exerts Pronounced Anti-Inflammatory Effects in Mice. J Agric Food Chem. 2017;65(43):9435-9442. doi:10.1021/acs.jafc.7b02979

¹²Solinas M, Goldberg SR, Piomelli D. The endocannabinoid system in brain reward processes. Br J Pharmacol. 2008;154(2):369-383. doi:10.1038/bjp.2008.130

¹³Scherma M, et al. Brain activity of anandamide: a rewarding bliss? Acta Pharmacologica Sinica vol. 40,3 (2019):309-323. doi:10.1038/s41401-018-0075-x

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¹⁵Ameri A, et al. Effects of the endogenous cannabinoid, anandamide, on neuronal activity in rat hippocampal slices. British Journal of Pharmacology vol. 126,8 (1999):1831-1839. doi:10.1038/sj.bjp.0702478
¹⁶Murillo-Rodríguez, E et al. “Anandamide modulates sleep and memory in rats.” Brain research vol. 812,1-2 (1998): 270-4. doi:10.1016/s0006-8993(98)00969-x

Are you looking for an advanced supplement formulation that promotes your cardiovascular health?

Are you aware of the different types of CoQ10 supplements available commercially?

Do you know about the novel approaches that enhance the bioavailability and absorption of CoQ10 in the body?

Get the answers to common queries about CoQ10 supplements, their different types and forms, the common absorption challenges associated with commercially available CoQ10 supplements, and the factors you should consider while determining the right CoQ10 supplement for your health. Use the links below to jump ahead to different topics on the page.

CoQ10 and Heart Health	How does CoQ10 Counter the Side Effects of Statins?
Ubiquinone or Ubiquinol — Which CoQ10 Supplement Form Works Better?	Absorption Challenges of CoQ10 Supplements
Novel CoQ10 Supplement Formulations for Enhanced Absorption	Are CoQ10 Supplements Safe?
How to Choose the Best CoQ10 Supplement	FAQs: Frequently Asked Questions

CoQ10 and Heart Health

Oxidative stress and mitochondrial dysfunction are potential factors contributing to cardiovascular disorders. 

• Oxidative Stress: Increased Reactive Oxygen Species (ROS) can inhibit nitric oxide (NO) availability — an important vasodilator factor. Low NO availability can result in arterial dysfunction due to the constriction of blood vessels, thereby making the heart work harder to pump blood. 
    
• Mitochondrial Dysfunction: Because oxidative metabolism in the mitochondria is the primary energy source of the heart, the inability to generate and transfer energy is considered the primary mechanism linking mitochondrial dysfunction and decreased cardiac contractility. 

Coenzyme Q10 (or CoQ10) plays a prominent role in electron transport and oxidative phosphorylation of mitochondria and acts as a cofactor in cellular energy production.* As a potent antioxidant, CoQ10 inhibits the oxidation of DNA and proteins to reduce oxidative stress in cardiac tissues.* With such a critical role in the optimal functioning of heart cells, it is not surprising that individuals who are experiencing cardiac dysfunction often have a CoQ10 deficiency.      

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How Does CoQ10 Counter the Side Effects of Statins?

Low-density lipoprotein (LDL) cholesterol (the “bad” cholesterol) builds up inside the arteries, making them narrower. Narrowing arteries makes it hard for the blood to circulate and increases the potential risks of heart attack or stroke. Statins reduce LDL cholesterol significantly and, consequently, the incidence of cardiac events. However, statins also have side effects, including CoQ10 depletion that results in cramping, muscle pain, and general weakness. These side effects are associated with a reduction in mitochondrial CoQ10.

The following table summarizes how CoQ10 supplements can counter the side effects of statin therapy¹.

CoQ10 and Statins
Increase in Creatine Kinase (CK): Statin intake is associated with an elevated level of the CK enzyme, which is found in skeletal muscles, heart muscles, and the brain. An elevated CK level can indicate damage to skeletal muscle or heart muscle. CoQ10 supplementation helps restore CK activity to its baseline level.*
Musculoskeletal toxicity: Statins can cause musculoskeletal toxicity, resulting in muscle cramping, soreness, fatigue, and, in rare cases, rapid muscle breakdown. CoQ10 supplementation enhances CoQ10 concentration in muscle cell membranes, thus countering these statin-induced conditions.

Ubiquinone or Ubiquinol — Which CoQ10 Supplement Form Works Better?

Both ubiquinone and ubiquinol are different forms of CoQ10, and most commercially available CoQ10 supplements are in one of these forms. 

• The fully oxidized Ubiquinone form (CoQ10): It is involved in the electron transport chain in the inner membranes of mitochondria for energy production.* 

• The fully reduced Ubiquinol form (CoQ10H2): It provides antioxidant protection to cellular membrane lipids and lipoprotein lipids present in circulation.*

There is much debate about the most effective form of CoQ10 supplementation. It was earlier hypothesized that ubiquinol is more bioavailable because regardless of the initial dietary form of CoQ10 (ubiquinone or ubiquinol), it remains in the blood and lymph in the ubiquinol form. CoQ10 molecules in the body convert back and forth from the oxidized state to the reduced state, depending on the body’s need for optimal cell function. 

Several studies suggest there is no statistically significant difference between the bioavailability of ubiquinone and ubiquinol supplements.

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Absorption Challenges of CoQ10 Supplements

Commercially available CoQ10 supplements include capsules, chewable tablets, oral sprays, and liquid syrups. However, the poor absorption of most CoQ10 supplements compromises their efficacy. The following table highlights the factors contributing to the low absorption and bioavailability of CoQ10.  

Why are Most CoQ10 Supplements Poorly Absorbed?
High molecular weight: Ubiquinol has a relatively high molecular weight that adversely affects its absorption in the gastrointestinal tract.
Instability: Because the ubiquinol form is unstable, it inhibits the absorption of CoQ10 in the body.
Limited solubility: CoQ10 is insoluble in water and shows limited solubility in lipids.

These factors slow down and limit the absorption of oral CoQ10 supplement formulations that use conventional delivery methods. Several recent studies indicate that solubilized CoQ10 formulations exhibit enhanced bioavailability².

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Novel CoQ10 Supplement Formulations for Enhanced Absorption

If CoQ10 absorption is limited through conventional delivery systems, then why can’t the CoQ10 concentration per capsule be elevated for the desired therapeutic benefits? Unfortunately, it is not a feasible approach to enhance the bioavailability of CoQ10.  

Notably, the bioavailability and absorption of a CoQ10 supplement depends on how it is formulated³. Because conventional CoQ10 supplement formulations fail to enhance the bioavailability of the active nutrient, several novel approaches have been explored to address these absorption challenges. The following table highlights some of the novel pharmacological approaches implemented to enhance the solubility of CoQ10. 

Novel Approaches to Enhance the Solubility of CoQ10 Formulations
Nanoparticles
Solid Dispersion Systems
Microcapsules
Nano-liposomes
Cyclodextrin inclusion compounds

It has been shown that encasing CoQ10 with cyclodextrins will significantly enhance CoQ10 absorption and bioavailability, indicating this delivery process is superior to formulations that feature only uncomplexed CoQ10. 

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Are CoQ10 Supplements Safe?

CoQ10 is produced naturally in the body and is also included in the diet as an additional supplement. The safety studies of CoQ10 supplements suggest that CoQ10 has low toxicity. 

The acceptable daily intake (ADI) of CoQ10 is 12 mg/kg/day⁴. 

In humans, the no-observed-adverse-effect level (NOAEL) of CoQ10 translates to 720 mg/day for an individual weighing 60 kg (or 132 pounds).  

Although preclinical and clinical studies indicate that CoQ10 is highly safe for use as a dietary supplement, there can be potential side effects of CoQ10 supplements.

Potential Side Effects of CoQ10 Supplements
Gastrointestinal side effects include nausea, stomach upset, vomiting, and diarrhea.
Headache, fatigue, heartburn, irritability, dizziness
Potential contraindications with prescription medicines for blood thinning, kidney and liver disorders, and glucose metabolism.

Hence, it is always recommended to consult with your healthcare provider before including a CoQ10 supplement in your diet.

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How to Choose the Best CoQ10 Supplement

CoQ10 supplements are conventionally produced through a yeast fermentation process. However, not all CoQ10 supplements are developed for optimal efficacy. When selecting the best CoQ10 supplement to support your cardiovascular health, you should consider a formulation that is:

• Bioavailable: Carrier lipids and the solubilization of the formulation determine the bioavailability of a CoQ10 supplement. The proportion and addition of preservatives, such as vitamin C, to supplement formulations also influence the bioavailability of the active nutrient.
  
  
• Easily Absorbed: CoQ10 can only be absorbed in the body as individual molecules. Raw CoQ10 is not easily absorbed in the gastrointestinal tract. The polymorphic crystals should be separated into single molecules throughout the formulation’s shelf life for enhanced absorption.

The formulation should also be manufactured using appropriate techniques and manufacturing standards to ensure the highest quality supplement available.

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FAQs: Frequently Asked Questions About CoQ10 Supplements

Can I take a CoQ10 supplement with a prescription medicine?

Although the safety profile of CoQ10 supplements is well established, they can have potential contraindications with prescription medicines. Always consult with your healthcare provider before including a CoQ10 supplement in your diet.

Can I take a CoQ10 supplement while pregnant or breastfeeding? 

The data is inconclusive on the safety of taking a CoQ10 supplement during pregnancy and breastfeeding. It is always recommended to consult with your healthcare provider before taking a CoQ10 supplement during pregnancy or when breastfeeding.

How do I choose the best CoQ10 supplement?

The efficacy of a CoQ10 supplement is determined in part by the delivery technology used in the formulation. Tesseract Medical Research’s CoQ10 Pro® is an innovative supplement formulation that uses the proprietary and ground-breaking CyLoc^® – DexKey^® nutrient delivery nanotechnology for unparalleled absorption of CoQ10 molecules in the intestinal tract. The unprecedented absorption of CoQ10 enables micro-dosing — taking CoQ10 in an amount much less than previously required to accomplish the desired therapeutic benefits to support your heart health.* 

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Citations:

¹Taylor BA. American journal of cardiovascular drugs: drugs, devices, and other interventions vol. 18,2 (2018): 75-82. doi:10.1007/s40256-017-0251-2

²Pravst, Igor et al. Nutrients vol. 12,3 784. 16 Mar. 2020, doi:10.3390/nu12030784

³Bhagavan HN, Chopra RK. Free radical research vol. 40,5 (2006): 445-453. doi:10.1080/10715760600617843

⁴Hidaka T, et al. BioFactors (Oxford, England) vol. 32,1-4 (2008): 199-208. doi:10.1002/biof.5520320124