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Butyrate supplement benefits help keep your gut happy.

Butyrate Supplement Benefits: An Overview

If you are looking for more information on how butyrate can support gut health, then you’re not alone. The beneficial effects of this short-chain fatty acid (SCFA) on maintaining gastrointestinal stability and energy metabolism have made it the subject of significant interest among practitioners, patients, and researchers alike.* The growing evidence of butyrate’s beneficial effect on the gut-brain axis further highlights its immense potential.  

Here’s what you need to know about this remarkably versatile molecule for promoting gut health and overall well-being, too.*

What Is Butyrate? 

Butyrate is also known as butanoic acid, and butyric acid.. This fatty acid is produced in the intestinal tract by microbial fermentation of undigested dietary carbohydrates—in other words, breaking down fiber. 

Butyric acid, along with acetic acid (found in vinegar) and propionic acid, make up 90-95 percent of the SCFAs in the human gut. Although it is the least abundant SCFA produced, butyrate is the main energy source for our colon cells (colonocytes), as it contributes  up to 60-70 percent of their energy requirements.* As the primary metabolic regulator for energy in those cells, butyrate yields therapeutic effects for functions both inside the intestinal tract and out.*

How Butyrate Supports Your Gut and Overall Health* 

Butyrate provides beneficial effects for several distinct systems. A growing number of studies have further revealed new results and nutritional support benefits of butyrate on a wide range of health functions.* The table below lists several examples in which butyrate plays an important role in benefiting the gastrointestinal environment and overall health.*

Beneficial Effects of Butyrate
Metabolic RegulationButyrate stimulates the colon to absorb sodium chloride (NaCl), guarding against symptoms of dehydration.*
Cell RegulationButyrate regulates the cell cycle — i.e.,  growth and division — by inducing changes in gene expression associated with multiple signaling pathways.* 
Intestinal-Barrier FunctionButyrate stimulates the MUC2 gene to produce mucin — the glycoproteins (mucus) produced by colonocytes, that acts as  a protective internal coating.* 
Oxidative StressPre-clinical studies1 have shown that butyrate modulates oxidative stress in the colonic mucosa — the glands and connective tissue that cover the inside of the colon.*  
Immune RegulationButyrate can influence immune responses in intestinal mucosa by modulating the migration of immune cells, their adhesion, and cellular functions.* 
Intestinal MotilityButyrate has been reported to enhance colonic motility — the peristaltic motion of the intestine that keeps you “regular.”* 

Beyond the gastrointestinal environment, butyrate has been found to display a range of benefits, like maintaining equilibrium through the gut-brain axis, which highlights its potential for addressing various health-related issues.  

Food Sources Containing Butyrate

You’ve probably heard that including fiber in your diet helps your digestion, sometimes communicated as “Eat more roughage.” The presence of undigested dietary fiber in the intestine is closely associated with the gut’s production of butyrate. Dietary fiber (“roughage”) refers to the edible plant parts resistant to digestion or absorption in the small intestine. 

These resistant dietary carbohydrates — made up of non-starch polysaccharides, non-digestible oligosaccharides, and resistant starch — are fermented into SCFAs by bacteria in the large intestine. Any remaining dietary fiber not broken down by bacteria travels intact to the colon and adds bulk and weight to stool, making it easier to pass.  

Let’s look at some food sources that add fiber to your diet and enhance butyrate production in the gut.


Beans, lentils, soybeans, and peas are all good sources of fermentable fiber. Dried legumes contain 20-30 percent resistant starch and also contain a high amount of galactooligosaccharides (GOS) – prebiotics made of plant sugars. 

Whole Grains

Whole grains, partially milled grains, cooked and cooled rice, and brans from cereals like wheat, rye, and oats are good sources of resistant starch. Studies report that consuming whole-grain cereals or brans can reduce intestinal transit time and accelerate the body’s production of butyrate from fiber.  

Fruits and Vegetables 

Apples, unripe bananas, plantains, apricots, kiwis, pears, blueberries, and raspberries contain fermentable fibers for butyrate production. Cooked and cooled potatoes are another great source of resistant starch. Red and green cabbages, leeks, garlic, broccoli, scallions, white onions, and kale all contain high levels of oligosaccharides.    

Nuts and Seeds

The coatings of nuts and edible seeds are another food source rich in resistant starch. Almonds are a good source of fiber, providing about three grams per ounce. Other seeds, like pistachios, sunflower kernels, and chia also add fiber to your diet.  

Dairy Products 

Moderate servings of full-fat dairy products, like cheese and butter, also help with butyrate production in the intestine. 

A well-balanced diet that includes a variety of these butyrate-rich food sources supports the intestinal ecosystem. The USDA recommends 38 grams of dietary fiber daily for men and 25 grams daily for women.   

Butyrate Supplements: An Alternative to Fiber-Rich Diets

So, if a fiber-rich diet helps with butyrate production, then why do you need a butyrate supplement to support your gut health?*

  1. Not all gut microbiomes are created equally. 
    Even with consuming the recommended amount of dietary fiber, your intestines might not produce the necessary level of butyrate. 
  1. Increasing fiber intake in your diet requires a habituation period. 
    A sudden increase in dietary fiber without sufficient fluids and exercise can lead to constipation and painful bowel movements. 
  1. You may be intolerant to a fiber-rich diet. 
    Some physiological conditions make it challenging for individuals to enhance the level of butyrate in their gut with increased fiber intake alone.

In such situations, butyrate supplementation offers a suitable alternative to dietary intake. The conventional method to increase butyrate supplementation is through oral ingestion of butyrate mineral salts or via a sodium butyrate enema. 

When considering an oral butyrate supplement, you might wonder whether it really works. Although several animal studies have established the beneficial effects of butyrate supplementation in maintaining a healthy gut microbiome,* let’s look at these benefits more closely. 

Butyrate Supplement Benefits 

Although research studies are inconclusive about the optimal intake of butyrate supplementation, 150 - 300 mg/day is usually the suggested amount for a butyrate supplement. Even in significantly higher amounts, clinical evidence2 indicates good tolerance of oral butyrate with no adverse reactions or side effects. Let’s look at how a butyrate supplement benefits you, compared to the oral intake of raw butyric acid.

Comparison: Raw Butyric Acid vs. Butyrate Supplement
Raw Butyric AcidButyrate Supplement
PalatabilityRaw butyric acid has a highly pungent odor and acrid taste, making it difficult to tolerate.
(i.e., It’s stinky and it tastes bad.)
Advanced supplement formulations make butyrate more palatable, resulting in patient compliance.
(i.e., Not horrible.)
AbsorptionRaw butyric acid is quickly absorbed in the upper part of the GI tract, reducing its beneficial effects lower down in the colon.
(Ineffective delivery.)
Encapsulated butyrate supplements have the capability to address the utility limitation of raw butyric acid if they are property designed and formulated to enhance both absorption and release  timing.
(Target acquired.)

These key butyrate supplement benefits make this short-chain fatty acid a reality for maintaining optimal gut health.*      

Choosing the Appropriate Butyrate Supplement 

Determining the right butyrate supplement can be challenging while analyzing the various products available on the market. The efficacy of a butyrate supplement depends on:

  • Bioavailability 
    Not all butyrate supplements are formulated alike. It is essential to select a butyrate supplement that is formulated to optimize both bioavailability and localized absorption in the required areas of the gut. 
  • Palatability
    The palatability of a butyrate supplement is equally critical for masking its unpleasant taste and odor and making it tolerable for oral intake.

ProButyrate® — a hypoallergenic butyrate formulation developed by Tesseract Medical Research uses a revolutionary delivery system that enhances the bioavailability and palatability of butyrate molecules. 

The proprietary CyLoc® - DexKey® nutrient delivery technology enables the delivery of butyrate molecules through the gastrointestinal tract — one palatable molecule at a time. CyLoc® technology encases each butyrate molecule and creates nano-sized particles, thereby masking its unpalatable taste and smell, and protecting it from breaking down during transit through the stomach. DexKey® technology accompanies each CyLoc® molecule and releases it at the desired point in the intestinal tract for maximum absorption and effectiveness. 

This unprecedented absorption of butyrate molecules in the gastrointestinal tract enables micro-dosing — using a lower amount of the active ingredient in the ProButyrate® formulation to achieve and help maintain a healthy inflammatory response in the gastrointestinal tract.* With ProButyrate®, you can take control of your gut health and introduce butyrate supplementation in your diet with ease.*

Tesseract Medical Research is committed to Good Manufacturing Practices (GMP). We utilize the most appropriate and scientifically-advanced analytical techniques, along with a well-designed quality control system to develop the finest quality nutritional supplements.  

Tesseract Medical Research is a pioneer in developing advanced supplement formulations with unprecedented absorption of active ingredients. Visit our website to learn more about butyrate supplement benefits and how our products support various health functions.


1Hamer HM, Jonkers DM, Bast A, et al. Clinical Nutrition 2009 Feb;28(1):88-93. doi: 10.1016/j.clnu.2008.11.002. Epub 2008 Dec 23. PMID: 19108937.
2Banasiewicz T, Domagalska D, Borycka-Kiciak K, Rydzewska G. Prz Gastroenterology 2020;15(2):119-125. doi: 10.5114/pg.2020.95556. Epub 2020 Jun 8. PMID: 32550943; PMCID: PMC7294979.

Al Czap, Founder | Tesseract

Al Czap has more than four decades of professional experience in preventative medicine. He founded Thorne Research in 1984 (sold in 2010) and he published Alternative Medicine Review for 17 years beginning in 1996. AMR was a highly acclaimed, peer-reviewed, and indexed medical journal. Al was the first to recognize the need for hypoallergenic ingredients and to devise methods of manufacture for and delivery of hypoallergenic products to underserved patient populations. His work has greatly impacted those with impaired immune and digestive systems and compromised health due to environmental exposures.

The advanced formulations based on our revolutionary, patented, and patent-pending technology are only available through Tesseract. No other medical, pharmaceutical, or supplement company is licensed to utilize our proprietary technology.
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
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