New evidence suggests berberine’s role in men’s health

Berberine and Men’s Health

Article Summary:

  • Berberine benefits testosterone levels in the body, suggesting its potential role in promoting men’s health.*

  • The poor bioavailability and absorption of unformulated berberine compromise its efficacy. The bitter taste of berberine further poses challenges to patient compliance. 

  • Tesseract’s BerberActiv® is a hypoallergenic berberine complex that supports a wide range of health functions in men.*  

Berberine is a plant-derived alkaloid — a class of nitrogenous organic compounds that support a wide range of health functions.* The therapeutic effects of berberine have been known for many years, and it has been traditionally used across different cultures. Extensive research has established berberine’s benefits and safety profile, especially its role in supporting glucose and lipid metabolism and healthy weight management.* 

Through various biochemical pathways, berberine promotes healthy hormone levels, particularly testosterone, insulin, and estrogen. Its role in modulating testosterone — a primary sex hormone in males — and exerting sex-specific effects indicate a close association between berberine and men’s health.*

The Correlation Between Berberine and Men’s Health

Berberine’s therapeutic effect on men’s health is attributed to its antioxidant properties and ability to help maintain the body’s natural inflammatory response.* These properties of berberine help limit oxidative damage to the male reproductive system and exert protective effects on sperm viability and motility rate to enhance sperm functions.   

  • Antioxidant Property: Berberine scavenges free radicals and protects cells from the detrimental effects of oxidative stress.* It has been found to enhance the level of glutathione and other antioxidant enzymes.*  
  • Maintaining A Healthy Immune and Inflammatory Response: Proinflammatory cytokines, the small secreted proteins released by cells, can cause adverse immune reactions. Berberine down-regulates the production of these proinflammatory cytokines to help maintain a healthy inflammatory response.*    
SystemBeneficial Applications
Endocrine System
  • Research1 has established berberine’s role in supporting healthy glucose metabolism.*
  • The antioxidant properties of berberine help protect the insulin-producing cells in the pancreas.*
  • Berberine supports healthy testosterone levels in men.*
  • A clinical trial2 highlights its role in limiting the optimal serum concentrations of testosterone and dihydrotestosterone, thereby promoting prostate health.*
Cardiovascular System
  • Berberine’s beneficial role in fatty acid oxidation, by up-regulating the adenosine monophosphate-activated protein kinase (AMPK) pathway, supports optimal cardiovascular health.*
  • By limiting lipid accumulation, berberine helps maintain a healthy low-density lipoprotein cholesterol (LDL-C) level.*
Hepatic System
  • Research3 indicates that men are more susceptible to liver pathologies.
  • The beneficial role of berberine in liver detoxification supports hepatic health in men.*
  • The liver contains the highest amount of berberine metabolites, suggesting berberine’s potential hepatoprotective effects.*
Neuro-Hormonal System
  • By promoting glucose and lipid metabolism, berberine helps in healthy weight management and supports overall body functions.*
Immune System
  • Berberine down-regulates immune cell-mediated inflammatory responses, thereby limiting adverse immune responses.*

Although berberine and men’s health are closely associated, the poor absorption of berberine, and its intensely bitter taste, hinder patient compliance and therefore its efficacy. Less than one percent of berberine is absorbed in the body due to its physico-chemical properties, rapid degradation, and rapid elimination from the body.

Various approaches have been used to enhance berberine’s palatability, bioavailability, and absorption. Advances in formulation technology, especially nanotechnology, have enabled enveloping berberine alone or with other agents to enhance its efficacy as a nutritional supplement.   

Incorporating Berberine Nanoformulations Into Your Diet

Tesseract Medical Research’s BerberActiv® is an innovative, nanoformulated bioactive berberine complex that provides nutritional support for the endocrine, cardiovascular, hepatic, and immune systems.* The proprietary CyLoc® – DexKey® nutrient delivery nanotechnology used in the supplement formulation transcends the common absorption and palatability issues of berberine, making its therapeutic benefits a reality.   

The CyLoc® technology encapsulates individual berberine molecules in its smart delivery system to retain their integrity and mask bitterness. The accompanying DexKey® reactors release each active nutrient molecule at the desired point in the intestinal tract for maximum absorption. The enhanced absorption of berberine enables micro-dosing — the intake of berberine in lesser amounts than previously required, to achieve rapid physiological responses. The result is unparalleled nutritional support for men’s health.* 

The power of Tesseract’s nutritional supplements lies in the proprietary science of proven nutrients and unrivaled smart delivery, making them the most effective for supporting endocrine health.*

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Citations

1Cao C, Meiqing S. Experimental and Therapeutic Medicine vol. 17,4 (2019): 3009-3014. doi:10.3892/etm.2019.7295

2Shabani, E, et al. MC Complementary Medicine and Therapies vol. 21,1 301. 20 Dec. 2021, doi:10.1186/s12906-021-03472-2

3Devarbhavi H, Asrani SK, Arab JP, et al. J Hepatol 2023 Aug;79(2):516-537. doi: 10.1016/j.jhep.2023.03.017. Epub 2023 Mar 27. PMID: 36990226.

Al Czap, Founder | Tesseract

Al Czap has more than four decades of professional experience in preventative medicine. He founded Thorne Research in 1984 (sold in 2010) and he published Alternative Medicine Review for 17 years beginning in 1996. AMR was a highly acclaimed, peer-reviewed, and indexed medical journal. Al was the first to recognize the need for hypoallergenic ingredients and to devise methods of manufacture for and delivery of hypoallergenic products to underserved patient populations. His work has greatly impacted those with impaired immune and digestive systems and compromised health due to environmental exposures.

The advanced formulations based on our revolutionary, patented, and patent-pending technology are only available through Tesseract. No other medical, pharmaceutical, or supplement company is licensed to utilize our proprietary technology.
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
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