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Berberine Benefits You Should Know About

Article Summary:

  • Berberine’s benefits are its antioxidant properties and its role in maintaining a healthy inflammatory response.* 
  • Berberine promotes endocrine health through glucose maintenance, liver detoxification, healthy weight management, hormonal balance, and gut microbiome support.* 
  • Tesseract’s BerberActiv® is an innovative supplement formulation that optimizes the solubility and absorption of berberine through a revolutionary nutrient delivery technology.

With the ongoing trend of touting berberine as a natural solution for optimizing blood glucose levels, you might wonder if you need a berberine supplement in your diet. The therapeutic benefits of berberine go beyond TikTok trends and have been known across different cultures for ages. In this article, we discuss berberine’s key benefits you should know about and why you should include a berberine supplement in your diet to promote optimal endocrine health.*

Key Berberine Benefits That Promote Your Health*

Berberine is a naturally derived compound from barberry, goldenseal, tree turmeric, Oregon Grape, and other similar plants. Chemically, berberine is an alkaloid that promotes normal body metabolism — the process of converting food to energy on a cellular level.* Several studies have established berberine’s role in promoting insulin secretion, enhancing insulin resistance, inhibiting lipogenesis (synthesizing fatty acids from non-lipid precursors), and regulating adipose tissue functions.* 

The following table highlights berberine benefits that promote endocrine health.*

Berberine Benefits That Promote Endocrine Health*
  • Glucose Maintenance: 
    1. Blood glucose regulation is primarily achieved through the hormones released by the pancreas. Berberine protects1 the insulin-producing cells in the pancreas, promotes insulin secretion, and limits insulin resistance through various signaling pathways.*
    2. Berberine limits glucose synthesis from non-carbohydrate sources (gluconeogenesis) in the liver and inhibits intestinal glucose absorption to help maintain healthy blood glucose levels.* 
  • Liver detoxification: 
    1. By inhibiting hepatic gluconeogenesis and the associated lowered oxygen uptake, berberine helps limit ammonia detoxification1 in the liver.*  
    2. Berberine promotes cholesterol excretion from the liver to bile, contributing to healthy blood lipid levels.*
  • Weight Management: 
    1. Berberine is associated with promoting weight management2 through enhancing metabolism, maintaining blood glucose levels, enhancing fatty acid oxidation, and inhibiting lipid accumulation, particularly low-density lipoprotein (LDL).*  
  • Hormonal Balance: 
    1. Berberine plays a critical role in maintaining hormone levels,3 such as insulin, estrogen, and testosterone that can address specific pathologies arising due to an imbalance of androgens (sex hormones) in females.*  
  • Gut Microbiome Support: 
    1. The gut microbiome is an endocrine organ that contributes to metabolic regulation. Clinical studies have established berberine’s role4 in altering gut microbiota and microbiota-associated bile acid metabolism.*   

The therapeutic effects of berberine on endocrine health can be significantly compromised due to its poor absorption and bioavailability. As a hydrophilic compound with a temperature-dependent aqueous solubility, berberine naturally displays poor membrane permeability. As a result, it will undergo first-pass elimination before it reaches systemic diffusion. 

In addition to its poor absorption, the intensely bitter taste of unformulated berberine poses a challenge to taking it in its natural form. A novel berberine supplement formulation can address these shortcomings.    

Including A Berberine Supplement in Your Diet

Commercially available berberine supplements utilize innovative approaches, including nanotechnology, to enhance berberine’s solubility and absorption. Notably, however, the safety and efficacy of berberine will greatly vary depending on the type of formulation.   

BerberActiv® is an innovative, hypoallergenic berberine supplement formulation developed by Tesseract Medical Research to support your endocrine health.* Tesseract’s proprietary CyLoc® – DexKey® nutrient delivery technology encases individual berberine molecules in its smart delivery system to maintain integrity and mask the bitter taste. The DexKey® reactors release berberine molecules at the desired point in the intestinal tract to achieve maximum absorption. Enhanced absorption enables micro-dosing — using a lesser amount of berberine than previously required to achieve a powerful and rapid physiological response. 

BerberActiv’s proprietary complex contains solubility-enhanced berberine derived from the root of Berberis aristata and is available in quick-release and sustained-release formulations. With enhanced absorption and targeted delivery of berberine molecules, BerberActiv® enhances blood glucose metabolism and supports your endocrine system.*   

The power of Tesseract supplements lies in enhancing palatability, maximizing absorption and bioavailability, and nano-dosing multiple nutrients in a single, highly effective capsule. Shop productson our website and learn more about how they can help support optimal health.*

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Citations: 

1Wei X, et al. Evidence-based complementary and alternative medicine : eCAM vol. 2016 (2016): 3593951. doi:10.1155/2016/3593951

2Ilyas Z, et al. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie vol. 127 (2020): 110137. doi:10.1016/j.biopha.2020.110137

3Caliceti C, et al. Oxidative medicine and cellular longevity vol. 2015 (2015): 723093. doi:10.1155/2015/723093

4Zhang L, et al. Frontiers in cellular and infection microbiology vol. 10 588517. 19 Feb. 2021, doi:10.3389/fcimb.2020.588517

Al Czap, Founder | Tesseract

Al Czap has more than four decades of professional experience in preventative medicine. He founded Thorne Research in 1984 (sold in 2010) and he published Alternative Medicine Review for 17 years beginning in 1996. AMR was a highly acclaimed, peer-reviewed, and indexed medical journal. Al was the first to recognize the need for hypoallergenic ingredients and to devise methods of manufacture for and delivery of hypoallergenic products to underserved patient populations. His work has greatly impacted those with impaired immune and digestive systems and compromised health due to environmental exposures.

The advanced formulations based on our revolutionary, patented, and patent-pending technology are only available through Tesseract. No other medical, pharmaceutical, or supplement company is licensed to utilize our proprietary technology.
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
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