Chemical structure of anandamide

Best Anandamide Supplement: What to Look For

  • Anandamide supplements support the endocannabinoid system and help maintain anandamide homeostasis to support healthy neurological function.* 
  • The best anandamide supplement is characterized by the ingredients it contains, its enhanced absorption and the bioavailability of active nutrients in a micro-dosing format.  
  • Tesseract’s AnaQuell® utilizes the proprietary CyLoc® – DexKey® nutrient delivery nanotechnology for unprecedented absorption of anandamide, to enhance its therapeutic potential. 

Anandamide, or the ‘bliss’ molecule, is a vital component of the body’s endocannabinoid system (ECS) that helps regulate and control several critical body functions.* Although our body produces anandamide naturally, certain factors can adversely impact the body’s ability to synthesize and maintain sufficient anandamide levels. A suboptimal anandamide level can adversely affect the entire body, particularly influencing the ability to cope with stress. 

The systemic intake of anandamide in the form of nutritional supplements has been associated with regulating neuronal signaling, thereby providing significant support for individuals experiencing stress and anxiousness (non-General Anxiety Disorder).* But what is the best anandamide supplement you can include in your regular diet? Understanding the key features of anandamide supplements and how these features can make a difference in positively influencing our emotional and mental well-being will help you select the right supplement formulation.  

Key Features of Best Anandamide Supplements

Let’s examine the intrinsic and extrinsic factors that affect anandamide levels in the body:

  • Genetic predisposition: Research shows that inhibiting the activity of the FAAH enzyme will limit the breakdown of anandamide, thereby enhancing its level.1 However, some individuals are genetically predisposed to higher anandamide levels due to a variant FAAH gene.
  • Stress-induced environments: Research highlights that stress-induced environments trigger a dip in anandamide levels, with continuous exposure to high-stress environments resulting in the down-regulation or the loss of the body’s CB1 receptors that anandamide binds to2. 
  • Aging: Age-dependent adaptive changes of endocannabinoid metabolism have also been found to adversely influence the level of anandamide in the body. 
  • Poor lifestyle choices: The runner’s high experienced by some individuals during and after endurance exercises is attributed to the release of endocannabinoids, particularly anandamide. A lack of physical activities and poor sleep habits, including an irregular sleep schedule, can adversely influence the circulating level of anandamide.  

Anandamide supplements support the endocannabinoid system by providing an adequate amount of anandamide to better regulate various physiological functions.* When looking for the best anandamide supplement, it is important to consider features of the formulation, including the quality of ingredients, nutrient delivery system, and recommended use. The following table highlights what you should look for to determine the best anandamide supplement.

What to Look for in Determining the Best Anandamide Supplement
  • Ingredients: Although the cellular uptake of anandamide is not well understood, studies indicate that a low concentration of anandamide enhances nitric oxide (NO) levels in platelet cells in the blood.* Binding of extracellular anandamide to cannabinoid receptors leads to the activation of nitric oxide synthetase (NOS) and intracellular nitric oxide production from L-arginine.3 Supplement formulations containing ingredients such as L-citrulline (a natural precursor of L-arginine) enhance overall  NO production, promoting blood flow and nutrient delivery to the brain.*
  • Optimal Absorption: Gastrointestinal enzymes hinder the intact absorption of anandamide in free form through the gut wall. Formulations using encapsulation techniques that trap anandamide molecules in nanocarriers are more readily absorbed through the gut wall.*  
  • Micro-Dosing: Anandamide intake in significantly higher amounts (3 mg/ kg) produces anxiety-inducing effects due to the overstimulation of CB1 receptors that anandamide binds to. This, in turn, can disrupt the brain’s reward circuitry. A supplement formulation that enables micro-dosing (the intake of anandamide in lesser amounts than previously required) helps maintain a sufficient level of anandamide in the body. 

  

The best anandamide supplement formulation enhances the absorption and bioavailability of anandamide in micro-doses, making the ‘bliss molecule’ a therapeutic reality.   

An Advanced Anandamide Formulation that Supports Your Health

Tesseract Medical Research’s AnaQuell® supplement is an innovative anandamide formulation that supports the body’s natural response to stress and anxiety (non-GAD).* The combination of anandamide and L-citrulline in Tesseract’s proprietary complex enhances nitric oxide production.* AnaQuell utilizes Tesseract’s proprietary CyLoc® – DexKey® nutrient delivery nanotechnology that solubilizes the anandamide, enabling its unprecedented absorption across the gut wall.*  The enhanced absorption and bioavailability of the anandamide in AnaQuell allow for micro-dosing of the active ingredient to promote emotional health and mental well-being.* 

Hypoallergenic AnaQuell formulations available in both quick- and sustained-release formats are manufactured in a Good Manufacturing Practices (GMP) – compliant environment, using scientifically advanced analytical techniques and a well-designed quality control system.   

The power of Tesseract supplements lies in enhancing palatability, maximizing absorption and bioavailability, and micro-dosing of multiple nutrients in a single, highly effective capsule. Shop products on our website and learn more about how they can support your neurological health.* 

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Citations:

1Ahn K, et al. Expert opinion on drug discovery vol. 4,7 (2009): 763-784. doi:10.1517/17460440903018857

2Morena M, et al. Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology vol. 41,1 (2016): 80-102. doi:10.1038/npp.2015.166

3Maccarrone, Mauro, et al. Journal of Biological Chemistry, vol. 275, no. 18, 2000, pp. 13484-13492, https://doi.org/10.1074/jbc.275.18.13484. Accessed 18 Aug. 2024.

Al Czap, Founder | Tesseract

Al Czap has more than four decades of professional experience in preventative medicine. He founded Thorne Research in 1984 (sold in 2010) and he published Alternative Medicine Review for 17 years beginning in 1996. AMR was a highly acclaimed, peer-reviewed, and indexed medical journal. Al was the first to recognize the need for hypoallergenic ingredients and to devise methods of manufacture for and delivery of hypoallergenic products to underserved patient populations. His work has greatly impacted those with impaired immune and digestive systems and compromised health due to environmental exposures.

The advanced formulations based on our revolutionary, patented, and patent-pending technology are only available through Tesseract. No other medical, pharmaceutical, or supplement company is licensed to utilize our proprietary technology.
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
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