Best Supplements for Heart Health

Article Summary:

  • Heart health supplements, including antioxidants and micronutrients, counter the adverse effects of reactive oxygen species (ROS) on cellular components.
  • The poor absorption of active ingredients in most heart health supplements adversely impacts their efficacy.
  • Tesseract’s proprietary nutrient delivery nanotechnology enhances the bioavailability and absorption of active nutrients.

A healthy diet is one of the best defenses against adverse cardiovascular health conditions. Many common cardiovascular health conditions are associated with oxidative stress, which occurs when there is an imbalance between reactive oxygen species (ROS) and the body’s antioxidant defenses. ROS are highly reactive molecules that can damage cellular macromolecules, including DNA, lipids, and proteins, even eventually resulting in cell dysfunction and even cell death. Increased ROS negatively impacts cardiovascular health through:

  • Lowering nitric oxide availability, leading to vasoconstriction and impaired blood flow
  • Causing arterial hypertension, leading to increased strain on the heart and blood vessels
  • Negatively influencing myocardial calcium handling, affecting the heart’s contractility and rhythym
  • Causing plaque buildup

Fortunately, our bodies have several natural enzymatic and non-enzymatic antioxidants that can counter ROS and oxidative stress. Specific vitamins, minerals, and compounds such as endocannabinoids, are also involved in the mitigating oxidative stress in cardiac cells. 

Below, we discuss some of the best supplements for heart health and an advanced heart supplement formulation developed by Tesseract Medical Research.

Best Supplements for Heart Health: An Overview

Antioxidants and micronutrients, including vitamins and minerals such as folic acid, vitamins C and E, selenium, copper, manganese, and zinc, are involved in pathways that mitigate oxidative damage and help maintain normal inflammatory responses in cardiac tissues and cells.* A healthy diet containing whole grains, fatty fish, fruits, and vegetables is rich in the antioxidants and micronutrients that support heart health. Heart health supplement formulations can fill any nutritional gaps in a balanced diet.   

The following table highlights some of the best supplements for heart health and how they promote healthy cardiovascular functions.*

Best Supplements for Heart Health

Folic Acid

Homocysteine is a critical amino acid produced by the body, and high levels of it can damage the inner lining of arteries. Folic acid lowers the plasma level of homocysteine.*

Vitamin C


Vitamin C enhances nitric oxide (NO) production, increasing vasodilation.* 

Vitamin E

Vitamin E is recycled back to its native unoxidized form by other antioxidants, such as vitamin C and CoQ10. A critical antioxidant activity of vitamin E helps terminate chain reactions triggered by lipid peroxyl radicals.* The cardio-protective effects of vitamin E include 1 inhibiting the oxidation of low-density lipoprotein (LDL) cholesterol in plasma.* 

Anandamide

Supplementation with endocannabinoids, such as anandamide and 2-arachidonoylglycerol, has been found 2 to cause beneficial hemodynamic changes in blood pressure and heart rate.* Endocannabinoids are synthesized from membrane phospholipids in the heart and other cardiovascular tissues. They act as a stress response system to relax coronary and other arteries.*

Coenzyme Q10

CoQ10’s antioxidant properties help 3 inhibit the oxidation of LDL.* CoQ10 helps down-regulate the activity of proinflammatory cytokines that can adversely affect the inner lining of arteries.*<

CoQ10 acts as a cellular membrane stabilizer to limit energy depletion from cardiac cells.* 

Quercetin

Quercetin modulates cell signaling pathways to inhibit oxidative damage to LDL.* Quercetin’s endothelium-independent vasodilator effect limits structural vascular alterations.* Quercetin supplementation has been found 4 to maintain normal blood pressure levels.

Citrulline

L-citrulline is found to be effective at increasing the concentration of L-arginine, a precursor for the synthesis of NO.* L-citrulline supplementation has been shown to help maintain healthy blood pressure levels.

Lipoic Acid

The antioxidant properties of lipoic acid help limit age-related oxidative stress on heart health.* It supports the functioning of vascular endothelium by enhancing the bioavailability of endothelium-derived NO.

Although the beneficial effects of these heart health supplements are well-established, their poor absorption can hinder the efficacy of most commercially available supplement formulations. Formulations using advanced nutrient-delivery technology can counter the absorption challenges of active nutrients to help realize their cardio-protective benefits.*   

Including Advanced Heart Health Supplement Formulations in Your Diet

Tesseract Medical Research has developed a range of advanced supplement formulations to promote your heart health.* The proprietary CyLoc® – DexKey® nutrient delivery nanotechnology enables the targeted delivery of active nutrients for optimal absorption. The CyLoc® technology encases active nutrient molecules in its smart delivery system, and the accompanying DexKey® reactors release molecules at the desired point in the intestinal tract. 

Some of the best supplements for heart health developed by Tesseract Medical Research are: 

  • AnaQuell®: It contains anandamide and L-citrulline as key ingredients to promote NO production and support optimal cardiovascular functions.* The formulation promotes a healthy response to mild anxiety (not GAD), stress, and mood changes.* 
  • CoQ10Pro®: The Coenzyme Q10 formulation maximizes its solubility and targeted delivery to the heart and muscle tissues to help maintain optimal heart health and support a healthy blood lipid profile.* 
  • NOX-FLO®: It contains a proprietary blend of clinically validated rutinosides Hesperidin 2S and Diosmin citrus flavonoids, CoQ10, citrulline, and R-lipoic acid to enhance NO production and support endothelial function and vasodilation.* 
  • QuerciSorb®: This quercetin formulation helps maintain healthy blood pressure, inhibits LDL oxidation, and provides optimal vasodilation to enhance blood flow.*  

Tesseract’s innovative nutrient delivery system helps realize the therapeutic potential of active nutrients to keep your heart healthy.*

The power of Tesseract supplements lies in enhancing palatability, maximizing bioavailability and absorption and bioavailability, and micro-dosing of multiple nutrients in a single, highly effective capsule.Shop products on our website and learn more about how they can support your cardiovascular health..* 

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Citations: 

1Vardi M, et al. Vitamin E . . . . Journal of Lipid Research vol. 54,9 (2013): 2307-2314. doi:10.1194/jlr.R026641

2​​Hiley CR. Endocannabinoids and the heart. Journal of Cardiovascular Pharmacology vol. 53,4 (2009): 267-276. doi:10.1097/FJC.0b013e318192671d

3Kumar A, et al. Role of coenzyme Q10 (CoQ10). . . . Pharmacology & Therapeutics vol. 124,3 (2009):259-268. doi:10.1016/j.pharmthera.2009.07.003

4Forney LA, et al. International Journal of Molecular Sciences vol. 19,3 895. 17 Mar. 2018, doi:10.3390/ijms19030895

5Allerton TD, et al. l-Citrulline Supplementation: Impact on Cardiometabolic Health. Nutrients vol. 10,7 921. 19 Jul. 2018, doi:10.3390/nu10070921

Al Czap, Founder | Tesseract

Al Czap has more than four decades of professional experience in preventative medicine. He founded Thorne Research in 1984 (sold in 2010) and he published Alternative Medicine Review for 17 years beginning in 1996. AMR was a highly acclaimed, peer-reviewed, and indexed medical journal. Al was the first to recognize the need for hypoallergenic ingredients and to devise methods of manufacture for and delivery of hypoallergenic products to underserved patient populations. His work has greatly impacted those with impaired immune and digestive systems and compromised health due to environmental exposures.

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