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Can I Take Glutathione and CoQ10 Together? Benefits and Considerations

Article Summary:

  • Glutathione and CoQ10 are important nutrients that promote the normal functioning of cells and protect cellular components against oxidative stress.*
  • Several studies that explored the combined effects of glutathione and CoQ10 established their role in enhancing the body’s antioxidant defense mechanisms.* 
  • Tesseract’s proprietary nutrient delivery technology enables optimal absorption and bioavailability of glutathione and CoQ10 to help achieve their health and wellness benefits.   

Oxidative stress occurs when the body’s natural antioxidant defenses are insufficient to neutralize its free radical load. This imbalance is a key underlying contributor to several health ailments adversely affecting various organs in the body. Elevated levels of oxidative stress could indicate a greater need for antioxidant supplementation. 

Glutathione, a tripeptide known as the body’s master antioxidant, is a critical molecule that helps the liver to detoxify, neutralizes free radicals, acts as a co-factor for several antioxidant enzymes, and is vital to mitochondrial function.*

Coenzyme Q10 (CoQ10 or ubiquinone) is a fat-soluble molecule that facilitates the transfer of  electrons within the mitochondrial oxidative respiratory chain to produce cellular energy (ATP). CoQ10 also enhances the production of vital antioxidants, such as superoxide dismutase, to mitigate oxidative stress.* Furthermore, CoQ10 can lower lipid peroxidation levels by inhibiting pro-oxidative compounds.*   

Both nutrients have immense therapeutic potential. The question can be asked whether glutathione and CoQ10 can be taken together, and the answer is yes. This post discusses the benefits of taking them together as supplements, supported by several studies that establish their synergistic effects. 

Studies Exploring the Combined Effects of Glutathione and CoQ10 Supplementation

The body has several enzymatic and non-enzymatic antioxidant mechanisms that scavenge free radicals (also called reactive oxygen species, or ROS). The major antioxidative enzymes in the enzymatic mechanism are glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD-1). The beneficial influence of CoQ10 on the activities of these two antioxidative enzymes to lower the level of ROS underscores the idea of taking CoQ10 and glutathione together. 

The following table highlights several studies that explore the combined beneficial health effects of glutathione and CoQ10.*


Combined Effects of Glutathione and CoQ10

  • Combined effects of glutathione and CoQ10 on reproductive health: In a randomized clinical trial, 83 infertile males were administered a combined supplementation of CoQ10, glutathione, l-carnitine/acetyl-l-carnitine, l-arginine, zinc, vitamin B9, vitamin B12, and selenium. The combined effects of the supplements enhanced mitochondrial bioenergetics to improve sperm quality.1 
  • Combined effects of CoQ10 and glutathione against lipid peroxidation: The unsaturated lipid peroxidation by ROS yields highly reactive lipid peroxyl radicals that can be neutralized by vitamin E (α-tocopherol). CoQ10 (ubiquinol) helps generate α-tocopherol antioxidant activity.


    The intermediate compound of these reactions (ubisemiquinone), further reacts with oxygen molecules or oxidizes further to the fully oxidized ubiquinone that does not react with oxygen. Reduced glutathione, NADP (an electron carrier), and other antioxidants, such as vitamin C, regenerate the oxidized CoQ10 (ubiquinone) and α-tocopherol and maintain their reduction states.*2

Ongoing research continues to explore the synergistic effects of glutathione and CoQ10. Although some studies remain inconclusive, the beneficial effects of glutathione and CoQ10 to enhance the body’s antioxidant defense system have been established.  

Can I Take Glutathione and CoQ10 Together? Factors to Consider 

Can glutathione and CoQ10 supplements be taken together? The answer is yes. However, when co-adminstering, the efficacy and safety of the supplement formulation should be considered. 

  • The efficacy of a supplement formulation is determined by the absorption and bioavailability of its ingredients. Nano-delivery of supplement ingredients by cyclodextrins, a type of stabilizing carrier, has been found to optimize both their absorption and their solubility. Advanced formulations utilizing such nutrient delivery achieve the health-promoting benefits of the nutrients. 
  • The safety of a supplement is equally crucial and is reflected in the manufacturing practices used to make the supplement. Nutritional supplements formulated with the optimal amount of active ingredients best achieve the desired therapeutic objective without causing adverse side effects. 

Tesseract Medical Research has developed glutathione and CoQ10 formulations that incorporate the advanced CyLoc® – DexKey® nutrient delivery nanotechnology. Molecules such as glutathione are naturally difficult to absorb, while supplemental CoQ10 has traditionally exhibited limited natural bioavailability. Using the Tesseract proprietary technology to deliver these nutrients at the desired point in the intestinal tract achieves optimal absorption. In addition, the unprecedented absorption of active nutrients enables micro-dosing —  using a lesser amount of ingredients than previously required to achieve the desired therapeutic outcomes. 

Tesseract combines the highest-quality nutrients with cutting-edge delivery systems to better support health and wellness. Tesseract follows Good Manufacturing Practices (GMPs), including scientifically advanced analytical techniques and quality control systems, to ensure the efficacy and safety of its supplement formulations. 

The power of Tesseract supplements lies in enhancing palatability, maximizing solubility, absorption and bioavailability, and micro-dosing multiple nutrients in a single, highly effective capsule. Shop products on our website and learn more about how they support the body’s antioxidant defense system..* 

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1Kopets R, et al. Dietary supplementation with a novel l-carnitine multi-micronutrient in idiopathic male subfertility involving oligo-, astheno-, teratozoospermia: A randomized clinical study. Andrology vol. 8,5 (2020): 1184-1193. doi:10.1111/andr.12805

2Turunen M, et al. Metabolism and function of coenzyme Q. Biochimica et Biophysica Acta vol. 1660,1-2 (2004):171-199. doi:10.1016/j.bbamem.2003.11.012

Al Czap, Founder | Tesseract

Al Czap has more than four decades of professional experience in preventative medicine. He founded Thorne Research in 1984 (sold in 2010) and he published Alternative Medicine Review for 17 years beginning in 1996. AMR was a highly acclaimed, peer-reviewed, and indexed medical journal. Al was the first to recognize the need for hypoallergenic ingredients and to devise methods of manufacture for and delivery of hypoallergenic products to underserved patient populations. His work has greatly impacted those with impaired immune and digestive systems and compromised health due to environmental exposures.

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