Various superfoods and supplements that are good sources of magnesium and quercetin.

Can I Take Quercetin and Magnesium Together for Immune and Heart Health Support?*

Article Summary:

  • Quercetin and magnesium are both known for their beneficial effects in promoting immune function and cardiovascular health.* 
  • Various studies have established the beneficial effects of supplementing with quercetin and magnesium. 
  • Tesseract’s proprietary nutrient delivery technology enables optimal absorption and bioavailability of quercetin and magnesium. 

Are you considering boosting your health and wellness with a combination of quercetin and magnesium supplements? Both of these nutrients have been individually linked to a variety of health benefits, and together, they may offer even more powerful effects.* Naturally, quercetin and magnesium are often found together, especially in foods like onions. Onions, in particular, are a major source of quercetin with 100 grams of raw onion containing between 28.4 – 48.6 mg of quercetin. Along with quercetin, raw onions are an excellent source of vitamin C, which play a key role in supporting immune health. 

But can quercetin and magnesium be effectively and safely combined in supplements? This post explains the potential benefits of taking quercetin and magnesium together, examining the evidence that suuports their synergistic effects. We will also explore why choosing advanced supplement formulations may be an effective way to include these nutrients in your diet and how they can contribute to overall health and wellness.  

Understanding the Combined Effects of Quercetin and Magnesium   

Beneficial Effects of Quercetin

Quercetin, one of the most abundant dietary flavonoids, is well known for its antioxidant properties and its ability to help maintain the body’s natural inflammatory response processes.* Due to its potent antioxidant activity, quercetin plays a role in scavenging free radicals to protect cellular components from oxidative stress.* 

This flavonoid inhibits the production of proinflammatory cytokines and leukotrienes, downregulates the release of histamine, and enhances the balance between T-helper cells to address adverse immune responses.* Quercetin also exerts cardioprotective effects, including beneficial effects on blood pressure, cholesterol levels, and endothelial function.*

Beneficial Effects of Magnesium

Magnesium is the fourth most abundant positively-charged ion in the body. Magnesium is a cofactor for more than 300 enzymatic reactions and facilitates the active transport of calcium and potassium ions across cell membranes. It also plays a beneficial role in the formation of bones, proteins, several enzymes, and cellular components, such as mitochondria, DNA, and RNA.*  

Magnesium is crucial to various immunological functions, including the activation of immune cells (T helper, B cell, and macrophages), lymphocyte proliferation, and immune cell adherence.* In the heart, magnesium exerts beneficial activity on neuronal excitation and intracardiac conduction, and regulates the proliferation and migration of endothelial and vascular smooth muscle cells.*

Combined Beneficial Effects of Quercetin and Magnesium

Several studies have explored the potential benefits of taking quercetin and magnesium together and have established the therapeutic effects of the co-supplementation. The following table highlights several such studies.  


Studies Exploring the Combined Beneficial Effects of Quercetin and Magnesium

  • Combined effects of quercetin and magnesium in addressing metabolic syndrome: A Chinese study on adults revealed that a higher intake of flavonoids, including quercetin and luteolin, combined with a high level of magnesium, was strongly associated with a lower risk of metabolic syndrome.1 
  • Antioxidant activity of quercetin-magnesium complex: A 2015 study investigating the activity of a complexed formation of quercetin and magnesium found that the free radical scavenging activity of quercetin was enhanced after being complexed with magnesium Mg(+2)) cation.*2

Quercetin has a low chemical stability and an inherent metal-chelating ability. Novel approaches to enhance its biological activity at a lower concentration include forming a quercetin complex with magnesium-doped calcium silicate ceramic that improves bone regeneration.*3

Can I take Quercetin and Magnesium Together? Key Considerations for Co-supplementation

Can I take quercetin and magnesium supplements together? Yes, you can. However, you should consider the following factors before including two or more nutritional supplements in your diet:

  • Consult with your healthcare provider: You should always consult your healthcare practitioner before beginning to take any nutritional supplement or including two or more nutritional supplements in your diet. Your healthcare practitioner knows your medical history and can analyze any potential contraindications of these supplement ingredients with prescription medicines you are taking.  
  • Understanding the efficacy of supplement formulations: The absorption and bioavailability of a supplement’s ingredients determine the supplement’s effectiveness. Not all supplements are formulated alike. Advanced supplements that utilize nanotechnology for targeted delivery of their active ingredients’ molecules enable optimal absorption of the nutrients to achieve their health-promoting benefits. 

Tesseract Medical Research has developed an innovative quercetin formulation that promotes healthy immune function and good cardiovascular health.* Tesseract’s proprietary CyLoc® – DexKey® nutrient delivery nanotechnology ensures the delivery of quercetin molecules at the desired point in the intestinal tract to maximize absorption. Unprecedented absorption enables micro-dosing; that is, using less quercetin than previously required to achieve the desired health benefits.

The power of Tesseract supplements lies in enhancing palatability, maximizing solubility, absorption and bioavailability, and micro-dosing multiple nutrients in a single, highly effective capsule. Shop products on our website and learn more about how they support your health and wellness.* 

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1Jin S, et al. The association of dietary flavonoids, magnesium and their interactions with the metabolic syndrome in Chinese adults: a prospective cohort study. The British Journal of Nutrition vol. 126,6 (2021):892-902. doi:10.1017/S0007114520004754

2Ghosh N, et al. Synthesis, characterization and study of antioxidant activity of quercetin-magnesium complex. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy vol. 151 (2015):807-813. doi:10.1016/j.saa.2015.07.050

3Preethi AM, Bellare, JR. Concomitant effect of quercetin- and magnesium-doped calcium silicate on the osteogenic . . . activity of scaffolds for bone regeneration. Antibiotics (Basel, Switzerland) vol. 10,10 1170. 27 Sep. 2021, doi:10.3390/antibiotics10101170

Al Czap, Founder | Tesseract

Al Czap has more than four decades of professional experience in preventative medicine. He founded Thorne Research in 1984 (sold in 2010) and he published Alternative Medicine Review for 17 years beginning in 1996. AMR was a highly acclaimed, peer-reviewed, and indexed medical journal. Al was the first to recognize the need for hypoallergenic ingredients and to devise methods of manufacture for and delivery of hypoallergenic products to underserved patient populations. His work has greatly impacted those with impaired immune and digestive systems and compromised health due to environmental exposures.

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