A closeup image of a bowl of curcumin powder

Curcumin Benefits You Should Know About

Article Summary:

  • The antioxidant and immunomodulatory and inflammation-modulating properties of curcumin benefit your joints, immune function, heart, gut, and liver.* 
  • The poor palatability, absorption, and bioavailability of curcumin significantly impact regimen compliance and the efficacy of most commercially available curcumin supplements.
  • Tetrahydrocurcumin, the bioactive metabolite of curcumin, has therapeutic benefits similar to curcumin but is more stable. 
  • Tesseract’s proprietary nutrient delivery technology enhances the palatability,  absorption, and bioavailability of tetrahydrocurcumin to support immune, cardiovascular, hepatic, and musculoskeletal health.*

Curcumin, the yellow polyphenolic pigment extracted from the roots of the turmeric (Curcuma longa) plant, has been used across multiple cultures for its therapeutic benefits. With clinical studies validating the beneficial effects of this wonder molecule, it is one of the top-selling nutritional supplements across the United States. But is curcumin worth including in your diet? You should know about curcumin’s key benefits to answer that question.  

Below, we discuss some of the benefits of curcumin as a nutritional supplement that promote your overall health, especially immune function and musculoskeletal health.* 

What are Curcumin’s Benefits: An Overview 

Research studies indicate that curcumin interacts with various signaling molecules and exhibits cellular-level activities in exerting its therapeutic benefits. The antioxidant properties of curcumin and its role in a healthy inflammatory response positively influence multiple health functions.* 

  • Antioxidant effects: Curcumin scavenges different types of harmful free radicals and modulates signaling pathways and activity of enzymes, such as glutathione peroxidase (GSH) and superoxide dismutase (SOD), to neutralize free radicals.*
  • Immunomodulatory effects: Curcumin inhibits the activity of key enzymes involved in inflammatory processes.* Curcumin also down-regulates the expression of pro-inflammatory cytokines — the proteins that control immune cell functions to help maintain the body’s natural inflammatory response.*

The following table highlights curcumin’s key benefits for joint health, immune support, cardiovascular health, gastrointestinal environment, and liver support.* 

Curcumin Benefits that Support Your Health

Joint support*

  • As a potent antioxidant, curcumin promotes a healthy inflammatory response to periodic musculoskeletal and joint flare-ups1.* 
  • Curcumin interacts with various molecular targets, such as NF-κB, that are involved in bone remodeling, indicating its potential role in supporting musculoskeletal and joint health2.*

Immune support*

  • Curcumin helps regulate the activation of immune cells — neutrophils, macrophages, dendritic cells, and natural killer cells3.*
  • Curcumin helps maintain the body’s natural inflammatory response by down-regulating the expression of pro-inflammatory cytokines and enzymes linked with immune cell activity4.* 

Cardiovascular support*

  • Curcumin’s role in modulating several signaling pathways involved in cell death, proliferation, and oxidative stress promotes heart health5.* 

Gastrointestinal support*

  • Curcumin and its metabolites have been shown to beneficially influence the gut microbiome6.*
  • There is ongoing research on the direct positive effects of curcumin on the gastrointestinal tract.* 

Liver Support*

  • Curcumin limits the concentration of lipids and fatty acid accumulation in hepatocytes or liver cells7.*
  • Curcumin’s antioxidant properties and beneficial impact on various signaling pathways, including the NF-κβ signaling, also establish its role as a hepatoprotective agent8.* 

Although curcumin benefits are well-established, the efficacy of most curcumin supplements can be significantly compromised because of curcumin’s naturally poor absorption and bioavailability. The poor palatability of curcumin also poses challenges to regimen compliance. If you are considering including a curcumin supplement in your diet, then you should look for an advanced formulation that enhances curcumin’s palatability, absorption, and bioavailability.

Including A Curcumin Supplement In Your Diet

When taken orally, curcumin rapidly breaks down into inactive metabolites that are eliminated from the gastrointestinal tract. Tetrahydrocurcumin, the bioactive metabolite of curcumin, displays physiological properties similar to curcumin but is more stable and is easily absorbed through the gut wall. 

TetraCumin®, developed by Tesseract Medical Research, combines the enhanced stability of tetrahydrocurcumin with the proprietary Cyloc® – DexKey® nutrient delivery technology to create a hypoallergenic curcumin formulation. The CyLoc® technology encases curcumin molecules to mask the unpleasant taste and odor while maintaining their integrity during the transit through the stomach. The DexKey® technology releases the curcumin molecules at the desired point in the intestinal tract, allowing for optimal absorption and bioavailability of each molecule. The smart nutrient delivery makes TetraCurcumin® an effective supplement formulation for supporting immune function and promoting bone health.* 

The power of Tesseract supplements lies in enhancing palatability, maximizing absorption and bioavailability, and micro-dosing multiple nutrients in a single, highly effective capsule. Shop products on our website and learn more about how they can support your immune function and musculoskeletal health.*

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Citation:

1Zhou H, et al. Current drug targets vol. 12,3 (2011): 332-347. doi:10.2174/138945011794815356

2,8Peddada, Krishi V et al. Orthopaedic surgery vol. 7,3 (2015): 222-31. doi:10.1111/os.12183

3Jagetia, Ganesh Chandra, and Bharat B Aggarwal. Journal of clinical immunology vol. 27,1 (2007): 19-35. doi:10.1007/s10875-006-9066-7

4Sikora, E et al. Immunity & ageing : I & A vol. 7,1 1. 17 Jan. 2010, doi:10.1186/1742-4933-7-1

5Farghadani, Reyhaneh, and Rakesh Naidu. Cancers vol. 13,14 3427. 8 Jul. 2021, doi:10.3390/cancers13143427

6Scazzocchio, Beatrice et al. Nutrients vol. 12,9 2499. 19 Aug. 2020, doi:10.3390/nu12092499

7Guariglia, Marta et al. Nutrients vol. 15,24 5053. 9 Dec. 2023, doi:10.3390/nu15245053

Al Czap, Founder | Tesseract

Al Czap has more than four decades of professional experience in preventative medicine. He founded Thorne Research in 1984 (sold in 2010) and he published Alternative Medicine Review for 17 years beginning in 1996. AMR was a highly acclaimed, peer-reviewed, and indexed medical journal. Al was the first to recognize the need for hypoallergenic ingredients and to devise methods of manufacture for and delivery of hypoallergenic products to underserved patient populations. His work has greatly impacted those with impaired immune and digestive systems and compromised health due to environmental exposures.

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