Article Summary:
- Curcumin supplements are among the top-selling nutritional supplements in the United States.
- The efficacy of most curcumin supplements is adversely affected by poor natural bioavailability and absorption.
- Tesseract’s advanced curcumin supplement formulation contains tetrahydrocurcumin, the most bioavailable form of curcumin, delivered through the proprietary CyLoc® – DexKey® nutrient delivery nanotechnology.
Are you considering including a curcumin supplement in your diet? The yellow pigment extracted from the roots of the turmeric plant is well-known for its multiple health benefits. Although turmeric has been used in many cultures for culinary and food coloring purposes for centuries, more recently the biological activities of turmeric are being extensively studied to understand its beneficial health effects.
Beneficial health properties of curcumin include musculoskeletal system, immune, cardiovascular, gut, and liver support.* Research studies indicate that curcumin can help manage several health-related conditions triggered by oxidative stress and adverse immune responses1.*
This article discusses the key benefits of curcumin supplements, how curcumin can support different systems in the body, and why you should include an advanced curcumin supplement in your diet for optimal health benefits.
How A Curcumin Supplement Benefits You
Curcumin’s benefits are attributable to its antioxidant and immunomodulatory properties2. Curcumin possesses a neutralizing effect on free radicals (agents of oxidative stress) making it a powerful antioxidant.* It helps to mitigate adverse immune reactions by decreasing several cell signaling pathways, including the nuclear factor NF-κB pathway3.* The following table highlights how a curcumin supplement can benefit your health and wellness.
| Curcumin Supplement Benefits You Should Know About | |
| Musculoskeletal system* |
Curcumin supplements may help mitigate exercise-induced inflammation and muscle soreness by promoting a healthy inflammatory response4.* This effect is critical in enhancing recovery from periodic musculoskeletal and joint flare-ups.* |
| Immune function* |
Curcumin supplements enhance the body’s natural defense capacity by up-regulating the activity of various immune cells (macrophages, dendritic cells, B, T, and natural killer cells)5. Curcumin has also been shown to support a healthy inflammatory response6.* |
| Heart health* |
Curcumin has been shown to positively affect several risk factors associated with cardiovascular conditions as well as limit oxidative stress to cardiac cells7.* |
| Gastrointestinal health* |
Recent research indicates that curcumin may positively affect the gut microbiome by favoring the growth of beneficial bacterial strains8.* Curcumin also helps promote a healthy inflammatory response in the intestinal tract9.* |
| Liver health* |
Curcumin supplements limit oxidative stress in the liver by inhibiting lipid peroxidation, free radical formation, and DNA damage10.* Curcumin interacts with various molecular and cellular mechanisms to exert hepatoprotective effects.* |
Curcumin has low toxicity, with minimal adverse side effects reported11. It is categorized by the U.S. FDA as a Generally Recognized As Safe (GRAS) nutrient. Although the health benefits of curcumin are well-established, it is always recommended to consult with your health-care provider before including a curcumin supplement in your diet.
It should be noted that natural curcumin alone does not yield the associated health benefits because of its poor absorption, poor bioavailability as well as rapid metabolism (elimination from the body). Adding other nutrients have been been shown to enhance curcumin’s bioavailability. For example, piperine, the primary active component of black pepper, is known to significantly increase curcumin’s bioavailability12.
Innovative curcumin formulations have recently displayed better absorption than free, unformulated curcumin. However, not all curcumin supplements are formulated the same. The poor absorption and bioavailability of curcumin continues to impact the efficacy of most new supplement formulations. Advanced curcumin formulations include various encapsulation techniques, including nanotechnology, in an effort to enhance the solubility of curcumin.
Including An Advanced Curcumin Supplement in Your Diet
TetraCumin®, developed by Tesseract Medical Research, is an advanced curcumin supplement formulation consisting of tetrahydrocurcumin – the most bioavailable form of curcumin.* Although tetrahydrocurcumin displays physiological properties similar to curcumin, it is more stable and more easily absorbed through the gut wall13.* The proprietary CyLoc® – DexKey® nutrient delivery nanotechnology further optimizes the solubility and absorption of tetrahydrocurcumin to better achieve the health benefits of this innovative curcumin supplement.
The CyLoc® technology encases individual tetrahydrocurcumin molecules to protect their integrity during their transit through the stomach. The accompanying DexKey® reactors release the CyLoc® molecules at the desired point in the intestinal tract for maximum absorption.
The unprecedented absorption through this revolutionary delivery technology results in rapid physiological responses to enhance tetrahydrocurcumin’s many health-promoting benefits.* TetraCumin’s advanced formulation enables micro-dosing, making it possible to take the supplement in lesser amounts than previously required to achieve the desired beneficial effects.*
The power of Tesseract supplements lies in enhancing palatability, maximizing absorption and bioavailability, and micro-dosing multiple nutrients in a single, highly effective capsule. Shop products on our website and learn more about how they can support your immune health.*
The power of Tesseract supplements lies in enhancing palatability, maximizing absorption and bioavailability, and micro-dosing multiple nutrients in a single, highly effective capsule. Shop products on our website and learn more about how they can support your immune health.*
Citations:
1Hewlings SJ, Kalman DS. Foods (Basel, Switzerland) vol. 6,10 92. 22 Oct. 2017, doi:10.3390/foods6100092
2Allegra A, et al. International Journal of Molecular Sciences vol. 23,23 14710. 25 Nov. 2022, doi:10.3390/ijms232314710
3Olivera, Anlys et al. International immunopharmacology vol. 12,2 (2012): 368-77. doi:10.1016/j.intimp.2011.12.009
4Fernández-Lázaro, Diego et al. Nutrients vol. 12,2 501. 15 Feb. 2020, doi:10.3390/nu12020501
5Farzaei MH, et al. Nutrients vol. 10,7 855. 1 Jul. 2018, doi:10.3390/nu10070855
6Peng, Ying et al. Drug design, development and therapy vol. 15 4503-4525. 2 Nov. 2021, doi:10.2147/DDDT.S327378
7Cox FF, et al. Cells vol. 11,3 342. 20 Jan. 2022, doi:10.3390/cells11030342
8Scazzocchio B, et al. Nutrients vol. 12,9 2499. 19 Aug. 2020, doi:10.3390/nu12092499
9Dulbecco, Pietro, and Vincenzo Savarino. World journal of gastroenterology vol. 19,48 (2013): 9256-70. doi:10.3748/wjg.v19.i48.9256
10Farzaei, Mohammad Hosein et al. Nutrients vol. 10,7 855. 1 Jul. 2018, doi:10.3390/nu10070855
11Soleimani V, Sahebkar A, Hosseinzadeh H. Phytother Res. 2018;32(6):985-995. doi:10.1002/ptr.6054
12Stati G, Rossi F, Sancilio S, Basile M, Di Pietro R. Front Pharmacol. 2021;12:780330. Published 2021 Oct 29. doi:10.3389/fphar.2021.780330
13Maiti, Panchanan et al. Antioxidants (Basel, Switzerland) vol. 10,10 1592. 11 Oct. 2021, doi:10.3390/antiox10101592
