Article Summary:
- Quercetin’s antioxidative and immunomodulatory properties contribute to its beneficial effects on gut health.*
- Quercetin’s naturally poor absorption and low bioavailability hinders the efficacy of most quercetin supplements.
- Tesseract’s innovative quercetin supplement formulation utilizes nutrient-delivery nanotechnology to enhance quercetin’s solubility.
When it comes to the pillars of our wellness, a healthy gut is essential.. The intestinal tract is the largest immune-regulating organ in the body, and the stable and balanced state of microbes is a prerequisite to maintaining various physiological roles. The loss of gut microbiome/microbial diversity is linked to several adverse health conditions.
The impact of nutrition on the composition of gut microbiota is well-documented1. Diet is a driving factor in shaping human gut microbiota composition and function. There is growing interest in targeting the human gut microbiota through diet and nutritional approaches to promote overall gastrointestinal health.
This blog post explains quercetin’s gut health-supportive properties and why you should include an advanced quercetin supplement in your diet.
Understanding Quercetin’s Gut-Health Supportive Properties
The intestine is perpetually exposed to both good and bad gut microbes and their metabolites, resulting in a close correlation between the intestine and human health. Oxidative stress and adverse inflammatory responses in the intestinal tract are linked to several adverse gastrointestinal conditions.
Typically, the cells of the gut wall are pressed tightly against each other, creating what are called tight junctions. These tight junctions prevent the gut’s contents from leaking into the bloodstream. However, when these tight junctions become disrupted (causing intestinal permeability), the immune system will upregulate an inflammatory response to counter the undigested food particles, bacteria, and toxins leaking into the bloodstream. Such unbalanced and adverse inflammatory responses negatively affect gut health.
Quercetin, a flavonoid naturally found in many fruits and vegetables in our diet, beneficially influences the gut environment and helps regulate the gut microbiota. Quercetin’s antioxidant properties and its ability to help maintain normal inflammatory responses in the gut hold immense positive potential to address gut health.
The following table highlights how quercetin’s gut health-supportive properties promote gastrointestinal health:
| System | Benefits |
|---|---|
| Quercetin’s Gut Health-Supportive Properties | |
| Limiting the production of pro-inflammatory cytokines* | Quercetin has been found to limit oxidative stress and help maintain normal inflammatory responses in lung epithelial cells.1 |
| Enhancing expression of endogenous antioxidant enzymes* | As a flavonoid with antioxidant properties, quercetin scavenges free radicals and enhances the expression of endogenous antioxidant enzymes, such as glutathione peroxidase, catalase, and superoxide dismutase.2 |
| Modulating gut microbial diversity and richness* | Quercetin modulates gut microbial diversity and richness by promoting the proliferation of beneficial bacteria and suppressing harmful pathogens, maintaining healthy intestinal flora.3 |
Additionally, quercetin is considered a prebiotic— a class of nutrients that beneficial gut microbes feed on. Prebiotics pass through the digestive system, promoting the growth and activity of the beneficial microbes in the digestive tract4.
While quercetin is generally present in our daily diet, the quantity of quercetin contained in food products may not result in meaningful gastrointestinal benefits. In addition, quercetin’s naturally poor absorption and low bioavailability hinder its efficacy in promoting gut health.
Getting the Most Out of a Quercetin Supplement
QuerciSorb® Immuphore SR, developed by Tesseract Medical Research, is an innovative nutritional supplement formulated with an optimally soluble form of quercetin that supports healthy gastrointestinal function.* Zinc (as zinc picolinate), vitamin C (as ascorbic acid), and vitamin D (as cholecalciferol) are other bioactive and bioavailable ingredients in this hypoallergenic formulation that support the gut’s optimal functioning.*
Tesseract’s proprietary CyLoc – DexKey® nutrient delivery nanotechnology achieves quercetin’s gut health-supportive properties.* The CyLoc® technology surrounds each quercetin molecule in its own smart delivery system to protect the molecule from too rapid degradation during transit through the stomach. The accompanying DexKey® reactors release each molecule at the desired point in the intestinal tract for optimal absorption.
The power of Tesseract supplements lies in enhancing palatability, maximizing solubility, absorption, and bioavailability, and micro-dosing a single or multiple nutrients in a single, highly effective capsule. Shop products on our website and learn more about how they support gastrointestinal health.*
References:
1Sul OJ, Ra SW. Molecules. 2021 Nov 17;26(22):6949. doi: 10.3390/molecules26226949. PMID: 34834040; PMCID: PMC8625571.
1Forney LA, et al. International Journal of Molecular Sciences vol. 19,3 895. 17 Mar 2018, doi:10.3390/ijms19030895
2Xu D, et al. Molecules (Basel, Switzerland) vol. 24,6 1123. 21 Mar 2019, doi:10.3390/molecules24061123
3Lin R, et al. Frontiers in Microbiology vol. 10 1092. 16 May 2019, doi:10.3389/fmicb.2019.01092
4Majid, Ishrat, et al. Food Chemistry Advances, vol. 4, 2024, p. 100725, https://doi.org/10.1016/j.focha.2024.100725. Accessed 4 Aug. 2025.
