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Best Heart Health Supplements

Oxidative stress is an underlying cause of several adverse cardiovascular conditions. When there is an imbalance between reactive oxygen species (ROS) and the body’s antioxidant defenses, this imbalance can cause damage to cellular macromolecules, including DNA, lipids, and proteins, which can eventually result in cell dysfunction and even cell death.* 

Increased ROS negatively impacts cardiovascular health by:

  • Lowering nitric oxide availability, which can lead to vasoconstriction and impaired blood* flow1.
  • Causing arterial hypertension, which can lead to increased strain on the heart and blood vessels2.
  • Negatively influencing myocardial calcium handling, which can affect the heart’s contractility and rhythm3. 
  • Causing plaque formation, leading to an increased risk of a cardiovascular event4. 

Fortunately, our bodies have several natural enzymatic and non-enzymatic antioxidants that counter ROS and oxidative stress. In addition, specific vitamins, minerals, and compounds such as endocannabinoids can also mitigate oxidative stress in cardiac cells. 

Get answers to common questions about the best heart health supplements, including how they support healthy heart function and why you should select an advanced supplement formulation to include in your wellness routine. Use the links below to jump ahead to a topic of interest.

Factors Affecting Heart HealthHeart Health and Diet
Best Heart Health Supplements — An OverviewAdvanced Heart Health Supplements to Include in Your Wellness Routine

Factors Affecting Heart Health

Your heart health can be adversely impacted by several factors, including: 

  • Health conditions: such as elevated blood pressure, imbalanced cholesterol levels, increased blood glucose levels, and poor weight management5.* 

Elevated blood pressure increases strain on the heart muscle,  arteries and other blood vessels which can negatively affect the heart and other major organs of the body, including the brain and kidneys. 

Imbalanced cholesterol levels, especially elevated LDL cholesterol can lead to a buildup of plaque in arteries, increasing the potential risks of heart attack or stroke6.* 

Increased blood glucose levels can, over time, damage blood vessels and nerves, which can compromise heart function. 

Poor weight management can contribute to the development of high blood pressure and high glucose levels that negatively affect heart health7. *

  • Lifestyle:  Diets high in trans fat, saturated fat, and cholesterol are associated with plaque buildup in arteries, increasing cardiovascular risk. Excessive salt intake may elevate blood pressure, while heavy alcohol use and tobacco products are also linked to heart disease8*. Additionally, a sedentary lifestyle with minimal physical activity can lead to higher blood pressure, elevated blood glucose, and increased cholesterol levels. 
  • Other factors: A family history of heart disease can significantly increase the risk of unhealthy heart conditions in an individual. The risk of heart disease also increases with age. 

Heart Health and Diet

A healthy diet can help keep your heart healthy. A heart-healthy eating plan focuses on fruits, vegetables, and whole grains, as well as fat-free and low-fat dairy products. The following are popular diet plans aimed at improving heart health:

  • Dietary Approaches to Stop Hypertension (DASH): This is a flexible and balanced eating plan focusing on daily and weekly nutritional goals. The DASH plan recommends the intake of: 
  • Fruits, vegetables, and whole grains
  • Fat-free and low-fat dairy products, poultry, beans, nuts, fish, and vegetable oils

The DASH diet recommends limiting the intake of sugar-sweetened food and beverages and foods high in saturated fats, such as full-fat dairy products and fatty meats. 

  • Mediterranean diet: This diet is based on the traditional cuisines of the countries that border the Mediterranean Sea. It is mostly plant-based, which means meals are built around vegetables, fruits, nuts, herbs, beans, and whole grains. The diet recommends a limited intake of red meat and foods with added sugar. 

Antioxidants and micronutrients, including vitamins and minerals such as folic acid, vitamins C and E, selenium, copper, manganese, and zinc, are involved in pathways that mitigate oxidative damage and help maintain normal inflammatory responses in cardiac tissues and cells. The following table highlights several macro- and micronutrients that should be included in a diet to promote heart health. 

Best Heart Health Nutrients

Nutrient

Cardiovascular benefits

Omega-3 fatty acids
  1. Omega-3 fatty acids, the key constituent of fish oil supplements, help maintain the normal inflammatory response in cardiac cells.9
  2. Omega-3 fatty acids enhance endothelial function by promoting the release of nitric oxide from endothelial cells.10 
  3. It has been found that omega-3 fatty acids help lower serum levels of triglycerides, enhance flow-mediated arterial dilation, and promote the heart’s mechanical function.11  

Folate
  1. The naturally occurring form of vitamin B9, aka folate, is associated with healthy vascular reactivity, allowing for normal dilation and constriction of the blood vessels.12 
  2. Folate acts as an essential co-factor in homocysteine-methionine metabolism. An elevated homocysteine level is associated with plaque buildup in arteries.13  

Vitamin D
  1. A low blood level of vitamin D can increase the risk of adverse cardiovascular conditions.6 
  2. The vitamin D receptor is expressed in cells throughout the vascular system. Vitamin D plays a role in inhibiting vascular smooth muscle proliferation and vascular calcification.7 
  3. Vitamin D helps regulate blood pressure volume and glucose metabolism, limiting adverse inflammatory responses in the cardiovascular system.8,9

Potassium
  1. Both a low or a high potassium level is linked to an irregular heartbeat.10 
  2. Potassium also helps maintain normal blood pressure levels.11 

Magnesium
  1. Magnesium activates the adenosine triphosphatase (ATPase) class of enzymes, which is essential for cell membrane functioning. A magnesium deficiency is associated with less polarized membrane potential, which can cause irregular heartbeat.12 
  2. Magnesium is a critical co-factor for the healthy functioning of the cardiac mitochondria (the cellular organelles responsible for producing the energy needed for cardiac muscular contraction and relaxation).13 
  3. Magnesium protects against potassium loss in the cardiac mitochondria, which is  critical for maintaining a healthy heart rate and rhythm.14 

Best Heart Health Supplements: An Overview

Heart health supplement formulations that contain active nutrients, such as coenzyme Q10, quercetin, citrulline, R-lipoic acid, and anandamide, support cardiovascular wellness by addressing potential nutritional gaps.. 

Active Nutrients in Heart Health Supplements

Anandamide
  • Endocannabinoids, such as anandamide and 2-arachidonoylglycerol, are synthesized from membrane phospholipids in cardiac tissues. The endocannabinoids exert their cardioprotective effects1 by —
  1. Acting as a stress response system.* 
  2. Inhibiting plaque buildup in arterial walls.* 
  3. Relaxing the coronary and other arteries to decrease cardiac exertion.* 

Coenzyme Q10
  • As an endogenous antioxidant that has its highest concentration in the heart, CoQ10 promotes heart health by2 —
  1. Lowering oxidative stress and mitochondrial dysfunction.* 
  2. Helping to maintain healthy levels of total cholesterol and low-density lipoprotein (LDL) levels.* 
  3. Enhancing endothelial function and limiting vascular stiffness.* 

Quercetin
  1. Inhibiting LDL oxidation in endothelial cells in arteries.*  
  2. Up-regulating the cell signaling pathways to inhibit oxidation of low-density lipoprotein (LDL).* 
  3. Helping to maintain normal blood pressure levels.*

Citrulline
  • The amino acid L-citrulline, found naturally in high concentrations in watermelon, exerts cardioprotective effects through4 —
  1. Enhancing endogenous synthesis of L-arginine and nitric oxide (NO) to help enhance vasodilation and maintain healthy blood pressure.* 

R-Lipoic Acid
  • A natural antioxidant synthesized in the mitochondria of the liver and other tissues, lipoic acid plays a critical role in metabolism.* Lipoic acid promotes heart health through5 —
  1. Regulating cellular oxidation and limiting oxidative stress on cardiac cells.*
  2. Scavenging reactive oxygen species (ROS) and regenerating other antioxidants, including glutathione and vitamins E and C.*   

Advanced Heart Health Supplements to Include in Your Diet

The poor natural absorption and bioavailability of many nutrients can impair their efficacy as ingredients in heart health supplements. Tesseract Medical Research optimizes the solubility of these active nutrients through its proprietary CyLoc® – DexKey® nutrient delivery nanotechnology. 

The following are some of the best heart health supplements developed by Tesseract Medical Research that achieve optimal therapeutic benefit of active nutrients for healthy heart function *

  • AnaQuell®: This formulation contains anandamide and L-citrulline as active nutrients to promote a healthy response to stress and anxiety (non-GAD).* L-citrulline, by enhancing NO production, promotes cardiovascular health.* 
  • CoQ10 Pro®: This formulation stands out among commercially available CoQ10 supplements because it enhances the solubility, absorption, and targeted delivery of CoQ10 molecules.* CoQ10 Pro promotes cardiovascular health and counters muscle pain, a common side effect of taking a cholesterol lowering prescription medication .* 
  • NOX Flo SR®: This proprietary blend – of Diosmin citrus flavonoids, Citrulline, Hesperidin 2S rutinosides, CoEnzyme Q10, and R-Lipoic Acid – enhances the synthesis of nitric oxide (NO) and promotes NO-dependent endothelial function and vasodilation.* 
  • QuerciSorb®: This proprietary quercetin complex helps maintain healthy blood pressure, down-regulates exaggerated immune responses, inhibits LDL cholesterol oxidation, and supports optimal heart functions.*

Tesseract’s proprietary nutrient delivery technology protects active nutrients from breaking down during their transit through the gastrointestinal tract and enables their targeted delivery in the body. The optimal absorption and bioavailability of active nutrients help achieve their benefits as heart health supplements. 

The power of Tesseract supplements lies in enhancing palatability, maximizing solubility, absorption and bioavailability, and micro-dosing multiple nutrients in a single, highly effective dose. Shop products on our website and learn more about how they support your heart health.*

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References:

1,2,4Förstermann U, Xia N, Li H. Circ Res. 2017;120(4):713-735. doi:10.1161/CIRCRESAHA.116.309326

3De Nicolo B, Cataldi-Stagetti E, Diquigiovanni C, Bonora E. Antioxidants (Basel). 2023;12(2):353. Published 2023 Feb 2. doi:10.3390/antiox12020353

5https://doi.org/10.1161/CIR.0000000000001186

6https://doi.org/10.1161/ATV.0000000000000164

7Bombelli M, Facchetti R, Sega R, et al. Hypertension. 2011;58(6):1029-1035. doi:10.1161/HYPERTENSIONAHA.111.175125

8Mukamal, Kenneth J. Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism vol. 29,3 (2006): 199-202.

9Duda MK, O’Shea KM, Tintinu A, et al. Cardiovasc Res 2009;81(2):319-327. doi:10.1093/cvr/cvn310

10Yamagata K. Curr Pharm Des 2020;26(30):3652-3666. doi:10.2174/1381612826666200403121952

11Mohebi-Nejad A, Behnood B. Omega-3 supplements and cardiovascular diseases. Tanaffos vol. 13,1(2014):6-14.

12Ganguly P, Sreyoshi FA. Nutrition Journal vol. 14 6. 10 Jan. 2015, doi:10.1186/1475-2891-14-6

5Duell PB, Malinow MR. Curr Opin Lipidol 1997;8(1):28-34. doi:10.1097/00041433-199702000-00007

6Leu M, Giovannucci E. Best Pract Res Clin Endocrinol Metab 2011;25(4):633-646. doi:10.1016/j.beem.2011.04.001

7Skibska B, Goraca A. Oxidative Medicine and Cellular Longevity vol. 2015 (2015):313021. doi:10.1155/2015/313021

8Li YC, Qiao G, Uskokovic M, et al. J Steroid Biochem Mol Biol 2004;89-90(1-5):387-392. doi:10.1016/j.jsbmb.2004.03.004

9Garbossa SG, Folli F. Rev Endocr Metab Disord 2017;18(2):243-258. doi:10.1007/s11154-017-9423-2

10Ravn-Jacobsen M, Jabbari R, Glinge C, et al. J Am Heart Assoc. 2020;9(4):e014160. doi:10.1161/JAHA.119.014160

11Houston MC. Curr Hypertens Rep. 2011;13(4):309-317. doi:10.1007/s11906-011-0197-8

12DiNicolantonio JJ, et al. Open Heart vol. 5,2 e000775. 1 Jul. 2018, doi:10.1136/openhrt-2018-000775

​​13Rabanal-Ruiz Y, et al. Antioxidants (Basel, Switzerland) vol. 10,5 755. 10 May. 2021, doi:10.3390/antiox10050755

14Chakraborti S, Chakraborti T, Mandal M, et al. Mol Cell Biochem 2002;238(1-2):163-179. doi:10.1023/a:1019998702946

15Bhaskar S, Sudhakaran PR, Helen A. Cell Immunol 2016;310:131-140. doi:10.1016/j.cellimm.2016.08.011

16Park S, Karunakaran U, Jeoung NH, et al. Curr Med Chem 2014;21(32):3636-3645. doi:10.2174/0929867321666140706141806

17Rabanal-Ruiz, Y, et al. Antioxidants (Basel, Switzerland) vol. 10,5 755. 10 May. 2021, doi:10.3390/antiox10050755

18Schmelzer C, Lorenz G, Lindner I, et al. Biofactors 2007;31(1):35-41. doi:10.1002/biof.5520310104

19Tsai KL, Huang YH, Kao CL, et al. J Nutr Biochem 2012;23(5):458-468. doi:10.1016/j.jnutbio.2011.01.011

20Liang S, Ping Z, Ge J. Oxid Med Cell Longev 2017:9863181. doi:10.1155/2017/9863181

21Serban MC, Sahebkar A, Zanchetti A, et al. J Am Heart Assoc 2016;5(7):e002713. Published 2016 Jul 12. doi:10.1161/JAHA.115.002713

22Bhaskar S, Sudhakaran PR, Helen A. Cell Immunol 2016;310:131-140. doi:10.1016/j.cellimm.2016.08.011

Al Czap, Founder | Tesseract

Al Czap has more than four decades of professional experience in preventative medicine. He founded Thorne Research in 1984 (sold in 2010) and he published Alternative Medicine Review for 17 years beginning in 1996. AMR was a highly acclaimed, peer-reviewed, and indexed medical journal. Al was the first to recognize the need for hypoallergenic ingredients and to devise methods of manufacture for and delivery of hypoallergenic products to underserved patient populations. His work has greatly impacted those with impaired immune and digestive systems and compromised health due to environmental exposures.

The advanced formulations based on our revolutionary, patented, and patent-pending technology are only available through Tesseract. No other medical, pharmaceutical, or supplement company is licensed to utilize our proprietary technology.
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
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