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How Does Anandamide Make You Feel?

Article Summary:

  • Anandamide is an endocannabinoid that promotes emotional and mental well-being.*
  • Anandamide helps alleviate anxiety-like behavior, contributes to ‘runner’s high,’ and enhances the levels of dopamine, the happy hormone.*
  • Tesseract’s advanced nutrient delivery technology achieves anandamide’s benefits through unprecedented absorption and bioavailability. 

Have you heard about the beneficial effects of anandamide on mental well-being?* This so-called ‘bliss molecule’ is the most studied among endocannabinoids due to its overall modulatory effect on the brain’s reward circuitry and beneficial influence on behavior and emotions.* Interestingly, although anandamide binds to the same cannabinoid receptors in the body that the psychoactive compound THC found in cannabis acts on, anandamide does not produce THC-like behavioral effects.*

So, how does anandamide make you feel? Can it alleviate mild anxiety (non-GAD) and up-regulate our emotions? This article explains the effects of anandamide and why you should include an anandamide supplement in your diet to promote your neurological health.*

How Does Anandamide Make You Feel? 

Let’s look at the psychotropic or mind-altering effects of THC before understanding the behavioral effects of anandamide. 

Δ9-tetrahydrocannabinol, or THC, is the primary psychoactive component of the plant Cannabis sativa. The chemical structure of THC is similar to anandamide, and it interacts directly with CB1 and CB2 cannabinoid receptors to mimic anandamide functions.  

Research suggests that THC may exert anxiogenic effects that stimulate the feeling of anxiety (non-GAD).* The psychotropic effects of THC can last for 4 – 12 hours and can cause altered perception, mood, cognition, consciousness, and behavior. Some of the adverse effects of THC overdosing include paranoia, anxiety and panic attacks, leading to increased heart rate and changes in blood pressure.  

On the other hand, anandamide is an endocannabinoid produced by the body that binds to and activates the CB1 cannabinoid receptors in the brain and other organs and tissues.* It also works as a neurotransmitter, sending chemical messages between neurons throughout the nervous system.* Evidence1 from preclinical studies shows that anandamide can exert anxiolytic effects that alleviate non-GAD anxiety.* Unlike THC, however, anandamide has a relatively shorter duration of action and rapid inactivation in the body.      

The following table highlights the key effects of anandamide and how it makes you feel.

How Does Anandamide Make You Feel — Key Effects
  • Anandamide helps alleviate anxiety-like behavior.*
    1. A clinical study2 on animal models indicated that lower levels of anandamide in the central nervous system may directly correlate with greater expression of anxiety-like behavior and stress-induced anxiousness.* 
    2. Research3 suggests that the anxiolytic effects of anandamide helps down-regulate learned fear by dampening its expression and enhancing its extinction.*
  • Anandamide contributes to the ‘runner’s high.’* 
    1. The release of endocannabinoids during and after endurance exercise is associated with the so-called ‘runner’s high’ — a brief, relaxing state of euphoria characterized by reduced stress and pain sensitivity.*
    2. A review4 of clinical studies highlights a rise in the level of anandamide after exercise.* Also, most studies and samples reported positive mood effects after exercise.* 
  • Anandamide promotes feelings of well-being.*
    1. Anandamide participates in modulating emotional states and is known to modulate5 the activity of dopamine, the ‘happy’ or ‘feel-good’ hormone.
    2. Dopamine is a key hormone that causes us to feel pleasure as part of the brain’s reward system. Anandamide’s role in beneficially enhancing dopamine levels highlights its involvement in promoting the feeling of well-being.*

Optimal natural production of anandamide by the body is critical for brain health. However, various factors can adversely affect the circulating level of anandamide, such as the enhanced activity of the fatty acid amide hydrolase (FAAH) enzyme, which increases the uptake of anandamide and breaks it down into ethanolamine and arachidonic acid. Incorporating anandamide-rich foods in your diet and adding an oral anandamide supplement can promote the production of the ‘bliss molecule’ in the body.*  

Including An Anandamide Supplement in Your Diet

Curious about how anandamide affects your mood and emotional balance? AnaQuellTM by Tesseract Medical Research offers a unique nutritonal supplements to help you discover its potential benefits. This innovative formulation combines anadamide oil with L-citrulline to promote a healthy response to mood changes, mild anxiety (not intended for Generalized Anxiety Disorder), stress, and trauma.* 

Tesseract’s proprietary nano-molecular CyLoc® —DexKey® nutrient delivery technology solubilizes anandamide molecules for delivery through the gut wall for unprecedented absorption. The sustained release of the hypoallergenic formulation supports the body’s natural response to stress and anxiousness for a prolonged duration.*

The power of Tesseract supplements lies in enhancing palatability, maximizing absorption and bioavailability, and micro-dosing multiple nutrients in a single, highly effective capsule. Shop productson our website and learn more about how they can support your neurological health.*

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Citations:

1,3Papagianni, Eleni P, and Carl W Stevenson. Current Psychiatry Reports vol. 21,6 38. 27 Apr. 2019, doi:10.1007/s11920-019-1026-z

2Bluett, R J et al. Translational psychiatry vol. 4,7 e408. 8 Jul. 2014, doi:10.1038/tp.2014.53

4Siebers, Michael et al. The Neuroscientist: a review journal bringing neurobiology, neurology and psychiatry vol. 29,3 (2023): 352-369. doi:10.1177/10738584211069981

5Oz, Murat et al. Journal of neurochemistry vol. 112,6 (2010): 1454-64. doi:10.1111/j.1471-4159.2009.06557.x

Al Czap, Founder | Tesseract

Al Czap has more than four decades of professional experience in preventative medicine. He founded Thorne Research in 1984 (sold in 2010) and he published Alternative Medicine Review for 17 years beginning in 1996. AMR was a highly acclaimed, peer-reviewed, and indexed medical journal. Al was the first to recognize the need for hypoallergenic ingredients and to devise methods of manufacture for and delivery of hypoallergenic products to underserved patient populations. His work has greatly impacted those with impaired immune and digestive systems and compromised health due to environmental exposures.

The advanced formulations based on our revolutionary, patented, and patent-pending technology are only available through Tesseract. No other medical, pharmaceutical, or supplement company is licensed to utilize our proprietary technology.
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
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