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Benefits of Quercetin for Healthy Aging

Article Summary:

  • Quercetin is a flavonoid with antioxidant, immuno-supportive, and anti-apoptotic properties that promote healthy aging. 
  • The poor bioavailability and absorption of quercetin impact its efficacy. 
  • Tesseract’s proprietary nutrient delivery technology optimizes the solubility and absorption of quercetin to make its use a therapeutic reality.   

Aging is a complex process associated with a progressive decline in cellular and physiological function, accumulation of damaged cells, and an increased risk of adverse chronic health conditions. One of the primary drivers of aging-related changes is the accumulation of cellular damage inflicted by free radicals, particularly reactive oxygen species (ROS). These highly reactive molecules are byproducts of normal metabolic processes but can cause significant harm when their production exceeds the body’s antioxidant defenses. This imbalance, known as oxidative stress, contributes to mitochondrial dysfunction, cell death, and adverse inflammatory responses–key mechanisms underlying aging and age-related disorders. 

Quercetin, a naturally occurring flavonoid found in a variety of fruits and vegetables, offers potential benefits for addressing oxidative stress.. As a lipophilic molecule with potent antioxidant properties, quercetin helps neutralize free radicals and maintain the body’s natural inflammatory responses.* Although the body cannot synthesize  quercetin, dietary intake or supplementation of this flavonoid can play a critical role in mitigating oxidative stress and promoting cellular resilience, thereby supporting healthy aging.* 

Below, we discuss quercetin’s benefits that help slow the progressive decline of essential health functions and support healthy aging.*

How does Quercetin Benefit Healthy Aging?

Quercetin is a bioactive compound commonly present in most diets. Found in different fruits and vegetables, such as apples, red grapes, citrus fruits, cherries, berries, onions, asparagus, and red-leaf lettuce, quercetin is one of the most abundant dietary flavonoids. Its diverse biological activities make quercetin a valuable nutrient for promoting healthy aging and supporting overall cellular health by functioning as an:

  • Antioxidant: It can effectively scavenge  reactive oxygen species (ROS).* By neutralizing ROS, quercetin helps preserve mitochondrial function and cellular integrity.*
  • Immunomodulant: It has the ability to help maintain the body’s natural inflammatory response, thus inhibiting adverse immune reactions.*
  • Anti-apoptotic: It has the ability to interfere with or inhibit the process of excessive apoptosis or programmed cell death to preserve cellular function and slow degenerative changes that occur with age.*

The following table highlights the mechanisms through which quercetin exerts its benefits on aging. 

How does Quercetin Support Healthy Aging? 

  • Limiting bone mass and bone mineral loss: Bone degeneration is a major aging-related condition. Quercetin benefits bone structure and the conformation of bone morphogenetic proteins (BMPs) through the upregulation of bone mineralization.* 
  • Up-regulating SIRT1 cell signaling pathway: SIRT1 protein promotes mitochondrial function, and its up-regulation inhibits cell death, promotes cell survival, and prolongs the lifespan of cells. Research1 indicates quercetin targets SIRT1 to regulate cellular senescence and multiple aging-related cellular processes.* 
  • Mitigating the effects of aging: Senescence-associated secretory phenotype (SASP) — a set of characteristics displayed by aging or senescent cells, includes the secretion of high levels of inflammatory cytokines, growth factors, immune modulators, and proteases. Quercetin helps limit the expression of senescent cell markers and inhibits the production of SASP.* 
  • Exerting benefits on the central nervous system: A study2 indicated that quercetin protects against age-related neurodegeneration.* Quercetin regulates the SIRT1/Nrf2/HO-1 cell signaling pathway, which counteracts and limits oxidative stress-mediated neuronal death.*
  • Limiting glutathione depletion: Quercetin enhances the activity of superoxide dismutase and catalase in the body, thereby inhibiting glutathione depletion.* By maintaining mitochondrial glutathione levels, quercetin protects against free radical damage to multiple cellular components.*  
  • Addressing immunosenescence: Quercetin has a direct beneficial effect on up-regulating the positive functions of immune cells, including inhibiting histamine and serotonin release from intestinal mast cells.* 
  • Inhibiting the activity of NF-κB signaling pathway: Quercetin inhibits3 the activity of the NF-κB signaling pathway, which protects cardiac tissues from damage caused by free radicals.* 

Although quercetin’s benefits and safety profile are well established, the poor natural bioavailability of quercetin in the gastrointestinal tract hinders its efficacy. Various pharmacological approaches, including nanotechnology, are aimed at enhancing quercetin’s solubility and subsequent absorption. 

Including Quercetin Benefits in Your Diet

Tesseract’s QuerciSorb® is an innovative quercetin formulation developed for optimal bioavailability and absorption. The proprietary CyLoc® – DexKey® nutrient delivery nanotechnology protects the integrity of quercetin molecules during their transit through the stomach and ensures targeted delivery. The CyLoc® technology encases individual quercetin molecules in its smart delivery system. The accompanying DexKey® reactors release each molecule at the desired point in the intestinal tract to achieve maximum absorption. 

With optimal solubility and absorption of quercetin, Quercisorb® can achieve quercetin’s multiple benefits for healthy aging.*

The power of Tesseract supplements lies in enhancing palatability, maximizing absorption and bioavailability, and micro-dosing multiple nutrients in a single, highly effective capsule. Shop antioxidant products on our website and learn more about how they can support your cardiovascular health.*

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Citations:

1,2Cui Z, et al. Therapeutic application of quercetin in aging. . . : SIRT1 as a potential mechanism. Frontiers in immunology vol. 13 943321. 22 Jul. 2022, doi:10.3389/fimmu.2022.943321

3Deepika and Pawan Kumar Maurya. Health benefits of quercetin . . . . Molecules (Basel, Switzerland) vol. 27,8 2498. 13 Apr. 2022, doi:10.3390/molecules27082498

Al Czap, Founder | Tesseract

Al Czap has more than four decades of professional experience in preventative medicine. He founded Thorne Research in 1984 (sold in 2010) and he published Alternative Medicine Review for 17 years beginning in 1996. AMR was a highly acclaimed, peer-reviewed, and indexed medical journal. Al was the first to recognize the need for hypoallergenic ingredients and to devise methods of manufacture for and delivery of hypoallergenic products to underserved patient populations. His work has greatly impacted those with impaired immune and digestive systems and compromised health due to environmental exposures.

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