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Does Quercetin Affect Sleep? FAQs

Quercetin is a flavonoid — a class of plant pigments displaying antioxidant effects and supporting the body’s natural response to inflammation (like curcumin, found in turmeric).* Quercetin is found in a wide range of fruits and vegetables, like apples, grapes, berries, tomatoes, shallots, onions, capers, seeds, and nuts, and in different plant parts, including bark, leaves, and flowers. 

As an antioxidant that neutralizes free radicals and limits oxidative stress in the body, quercetin has immense therapeutic potential to benefit various health conditions, including those related to sleep.* 

Many traditional East Asian cultures credit lotus leaf extract for its sleep-enhancing effects. Notably, the lotus leaf contains high levels of flavonoids — specifically, quercetin and its derivatives*

Below, we discuss some of the most frequently asked questions about quercetin, its therapeutic benefits in attenuating behavior caused by sleep deprivation, safety and tolerance levels, and its ingestion in supplement forms to support your overall health.*     

Frequently Asked Questions (FAQs): Quercetin and Sleep 

Let’s look at some of the common questions that might come to mind when you consider supplementing with quercetin to improve your sleep.

How does quercetin impact sleep? 

Current research suggests the potential role of quercetin in modulating the sleep-wake cycle by activating GABA receptors — the chief inhibitory receptors for the central nervous system.* In an animal study1, quercetin limited brain oxidative stress induced by paradoxical sleep, or REM sleep deprivation, in mice.* 

How should I take quercetin?

A diet rich in fruits, vegetables, nuts, and seeds can naturally enhance your quercetin intake.  Quercetin supplements are also a suitable alternative for both oral ingestion and topical application. While oral ingestion of quercetin helps support the immune system, cardiovascular health, sleep regulation, and others, topical applications of quercetin are primarily aimed toward wound healing. It is recommended to consult with your healthcare practitioner before including a quercetin supplement in your diet or applying it topically.    

How much quercetin should I consume for therapeutic benefits?

Isolated quercetin as a nutritional supplement at  1000 mg/day3 is considered a safe usage. Among the published human intervention studies,4 adverse effects of quercetin supplementation have rarely been reported and any such adverse effects were mild in nature. However, it is worth noting that adequate published scientific data is not yet available to assess the safety of long-term usage (12 weeks or more) of high supplemental quercetin levels (1,000 mg daily or above).   

Why should I take a quercetin supplement?

Although the therapeutic activities of quercetin are well established,* it has poor water solubility, chemical instability, and low bioavailability.5 Quercetin requires zinc to activate its therapeutic effects on the body. So, it is not a coincidence that zinc, the second most abundant trace metal in the body, is also involved in sleep regulation. The current research data6 suggest that zinc consumed orally enhances the amount and quality of sleep in mice and humans.   

You might consider taking a nutritional supplement that contains both quercetin and zinc to improve the body's absorption of quercetin. Quercetin binds to zinc and acts as a transporter, carrying zinc ions across the cell membrane to enhance the intracellular zinc concentration.*  

Is it safe to consume quercetin with prescription medicines?

Although quercetin is widely considered to be safe as a nutritional supplement, you should consult with your health-care provider before including a quercetin supplement in your diet. Insufficient research data exists on quercetin effects during pregnancy and breastfeeding. So, it is always recommended to seek medical advice before consuming a quercetin supplement with any prescription medicine.     

How do I determine the best quercetin nutritional supplement to support my health?

An effective quercetin nutritional supplement offers enhanced bioavailability of the active ingredient for optimal therapeutic benefit.* QuerciSorb® Immophore SR — an innovative nutritional supplement developed by Tesseract Medical Research — contains bioactive, soluble, and absorbable quercetin, along with zinc, vitamin D, and vitamin C to support your overall health.* The revolutionary CyLoc® - DexKey® nutrient delivery technology ensures that quercetin  is delivered one molecule at a time at the desired point in the intestinal tract and absorbed through the gut wall, along with other therapeutic ingredients. Developed for sustained release (SR), QuerciSorb® Immuphore SR makes it easy for the body to absorb and use quercetin effectively.

The power of Tesseract supplements lies in enhancing palatability, maximizing bioavailability and absorption, and micro-dosing multiple nutrients in a single, highly effective capsule. Shop products on our website and learn more about how they can help support cardiovascular health.*

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Citations:

1 Kanazawa, Luiz KS, et al. Free Radical Biology & Medicine vol. 99 (2016): 79-86. doi:10.1016/j.freeradbiomed.2016.07.027

3Deepika, Maurya PK. Molecules 2022 Apr 13;27(8):2498. doi: 10.3390/molecules27082498. PMID: 35458696; PMCID: PMC9032170.

4Andres, Susanne et al. Molecular Nutrition & Food Research vol. 62,1 (2018): 10.1002/mnfr.201700447. doi:10.1002/mnfr.201700447

5Acıkara OB, Karatoprak GŞ, et al. CNS Neurol Disord Drug Targets 2022;21(9):795-817. doi: 10.2174/1871527320666211206122407. PMID: 34872486.
6 Yoan C, Urade Y. International Journal of Molecular Sciences vol. 18,11 2334. 5 Nov. 2017, doi:10.3390/ijms18112334

Al Czap, Founder | Tesseract

Al Czap has more than four decades of professional experience in preventative medicine. He founded Thorne Research in 1984 (sold in 2010) and he published Alternative Medicine Review for 17 years beginning in 1996. AMR was a highly acclaimed, peer-reviewed, and indexed medical journal. Al was the first to recognize the need for hypoallergenic ingredients and to devise methods of manufacture for and delivery of hypoallergenic products to underserved patient populations. His work has greatly impacted those with impaired immune and digestive systems and compromised health due to environmental exposures.

The advanced formulations based on our revolutionary, patented, and patent-pending technology are only available through Tesseract. No other medical, pharmaceutical, or supplement company is licensed to utilize our proprietary technology.
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
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