Article Summary:
- Botanical extracts, such as turmeric, Boswellia, and pine bark extracts, are commonly used in joint support supplement formulations.
- The poor bioavailability and absorption of these ingredients hinder the efficacy of most commercially available joint support supplements.
- Tesseract’s revolutionary nutrient delivery nanotechnology enables unprecedented absorption of active nutrients to realize their potential as therapeutic agents for supporting bone health.*
Joint stiffness, tenderness, and discomfort in areas such as the hips, knees, hands, and feet can significantly limit daily activities and negatively impact quality of life.. Studies1,2 show that oxidative stress plays a key role in the wear-and-tear of cartilage and bones, contributing to discomfort and mobility issues. Proper nutrition and regular, moderate exercise are essential for mitigating free radical damage to bone cells, helping to protect and support joint health. Additionally, targeted dietary supplements may help address nutritional gaps and promote better joint health.*
Joint support supplements are oral supplement formulations that help alleviate periodic musculoskeletal and joint flare-ups resulting from oxidative stress.* These formulations generally contain botanical extracts, such as turmeric, Boswellia, and pine bark, or compounds such as glucosamine and chondroitin to support bone health.*
Below, we discuss the relationship between oxidative stress and joint health, how joint support supplements address oxidative stress, and why you should consider including an advanced joint support supplement formulation in your diet.
How Does Oxidative Stress Affect Joint Health?
Oxidative stress arises from the imbalance between reactive oxygen and nitrogen species (ROS/RNS) and the antioxidants that constitute the body’s defense system. Although ROS are naturally produced in all cells and are involved in cell cycling and gene regulation, increased ROS production can damage cellular structures and disrupt cellular homeostasis.
ROS production and oxidative stress are commonly observed in individuals with joint conditions, underscoring the adverse effects of free radicals on bone and joint health. For example, oxidative stress significantly contributes to the cell death (apoptosis) of chondrocytes — the cells responsible for cartilage formation. Key ways in which oxidative stress affects bone and joint health include:
- Mitochondrial dysfunction
- Increased cartilage degradation
- Increased swelling of the synovial membrane, a specialized connective tissue that lines the inner surface of most joints
- Increased subchondral bone dysfunction
- Decreased synthesis of bone matrix — the intracellular substance of bone tissue that contributes to bone mass
- Aging and apoptosis of chondrocytes
Additional intake of antioxidants through diet or joint support supplements can help maintain joint homeostasis.* Antioxidant molecules scavenge free radicals, limit their adverse effects on bone cells, and help maintain natural inflammatory responses to limit joint aches and soreness.
How Do Joint Support Supplements Address Oxidative Stress?
Let’s look at how several plant-derived compounds act as antioxidants and down-regulate overactive inflammatory responses by the immune system to limit the adverse effects of oxidative stress on bones, cartilage, tendons, and ligaments.*
The following table highlights several common botanical extracts in commercially available joint support supplements.
Ingredients in Joint Support Supplements: How Do They Work? |
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While the therapeutic effects of these ingredients are well-established for bone health, the poor bioavailability and absorption of the compounds impact the efficacy of joint support supplement formulations. This highlights the importance of an advanced nutrient delivery system that optimizes the solubility and absorption of active nutrients.
Including a Joint Support Supplement In Your Diet
TetraCumin® is an innovative tetrahydrocurcumin formulation developed by Tesseract Medical Research for joint support.* The joint support supplement contains tetrahydrocurcumin — the bioactive curcumin metabolite that is more stable and bioavailable than curcumin. The proprietary CyLoc® – DexKey® nutrient delivery nanotechnology further enhances the palatability and bioavailability of the active nutrient, delivering the nutrient molecules at the desired point in the intestinal tract, resulting in optimal absorption. The unprecedented absorption helps realize the therapeutic potential of tetrahydrocurcumin, yielding desired and rapid beneficial responses to promote joint health.*
The power of Tesseract supplements lies in enhancing palatability, maximizing absorption and bioavailability, and micro-dosing multiple nutrients in a single, highly effective dose. Shop products on our website and learn more about how they can support your joint health.*
Citations:
1Zahan O-M, et al. The evaluation of oxidative stress in osteoarthritis. Medicine and pharmacy reports vol. 93,1 (2020):12-22. doi:10.15386/mpr-1422
2Bolduc JA et al. Reactive oxygen species, aging and articular cartilage homeostasis. Free Radic Biol Med. 2019;132:73-82. doi:10.1016/j.freeradbiomed.2018.08.038
23Huang G, et al. Pycnogenol(®) treatment inhibits bone mineral density loss and trabecular deterioration in ovariectomized rats. International journal of clinical and experimental medicine vol. 8,7 10893-901. 15 Jul. 2015
4Panahande SB, Maghbooli Z, Hossein-Nezhad A, et al. Effects of French maritime pine bark extract (Oligopin®) supplementation on bone remodeling markers in postmenopausal osteopenic women: A randomized clinical trial. Phytother Res. 2019;33(4):1233-1240. doi:10.1002/ptr.6320
5Wang A, Leong DJ, He Z, et al. Procyanidins Mitigate Osteoarthritis Pathogenesis by, at Least in Part, Suppressing Vascular Endothelial Growth Factor Signaling. Int J Mol Sci. 2016;17(12):2065. Published 2016 Dec 9. doi:10.3390/ijms17122065
