Article Summary:
- Quercetin’s antioxidative and immunomodulatory properties are hindered by quercetin’s naturally poor bioavailability and absorption.
- When choosing the best quercetin supplement, you should look for the best active nutrient, as well as optimal solubility, absorption, and bioavailability.
- Tesseract’s proprietary CyLoc® – DexKey® nutrient delivery nanotechnology overcomes quercetin’s natural absorption challenges to achieve enhanced bioavailability.
Quercetin’s beneficial antioxidant and immunomodulatory properties make it a unique nutritional supplement.* The flavonoid, quercetin, found in various fruits and vegetables, is an antioxidant that helps maintain normal inflammatory responses in cells.* Quercetin promotes several health functions, including immune function, renal function, and cardiovascular function.
While quercetin is naturally available through dietary sources,, it is unfortunately also known for its poor absorption and limited bioavailability. This means that even if you are consuming a meal high in quercetin-containing foods ,, It is estimated that only 3-7 percent of quercetin glycoside (the most absorbable form of quercetin) is absorbed after ingesting at least 100 mg. Meaning, you are likely not absorbing enough quercetin to benefit from its healing properties from dietary sources alone.1
Various approaches have been explored to enhance quercetin’s absorption and bioavailability. For example, co-supplementation of quercetin with other nutrients can enhance quercetin’s solubility and thus benefit the body’s natural immune responses.* Advancements in nutrient delivery technologies, such as nanotechnology, have also enhanced quercetin’s bioavailability.
, When looking for the best quercetin supplement, what factors should you consider? This blog post explains key features of the best quercetin supplements and why you should include an advanced quercetin supplement formulation in your diet.
Key Features of the Best Quercetin Supplements
When considering including a supplement in your “wellness plan” or “health routine”, you want a formulation that helps you achieve quercetin’s many health-promoting benefits. The health-promoting benefits of the best quercetin supplements depends on the flavonoid’s solubility, absorption, and bioavailability.
The following table highlights the key features of the best quercetin supplement formulations for supporting optimal immune function:*
| Best quercetin supplement: What to Look for | |||
|---|---|---|---|
| Solubility | Quercetin’s solubility in aqueous solutions is low and pH-dependent. Supplement formulations that contain liposomes, nanoemulsions, and micelles can enhance quercetin’s water solubility. 2 | ||
| Absorption | Quercetin is absorbed in the upper segment of the small intestine. Its absorption varies based on the type of formulation. Formulations containing quercetin-loaded nanoparticles display better absorption than other delivery methods. | ||
| Bioavailability | Enhancing quercetin’s water solubility also increases its bioavailability. Phospholipid complexes of quercetin increase the compound’s water solubility approximately 13-fold, 3 thereby increasing bioavailability significantly compared to free quercetin. | ||
| Type of formulation | Oral, intravenous, intranasal, and topical administration of quercetin enhances its stability in the gastrointestinal environment and minimizes its intestinal degradation. In clinical studies, formulated quercetin displays a significant rise (more than 200%) in blood uptake compared to unformulated quercetin. 4 | ||
| Active nutrients | A quercetin supplement containing zinc and vitamins C and D3 exerts synergistic effects to better promote immune health.* Zinc enhances quercetin’s health-promoting benefits, whereas quercetin enhances zinc’s intracellular concentration. | ||
Looking at the product’s Supplement Facts label enables you to gather the required information about a quercetin supplement formulation, such as the active nutrients in the formulation, formulation type, delivery technology used, and recommended usage. You should also speak with a trusted healthcare provider to better understand the safety of a supplement formulation and the potential contraindications and interactions with any prescription medications or other supplements you are taking .
Including An Advanced Quercetin Formulation in Your Diet
QuerciSorb® Immuphore SR, developed by Tesseract Medical Research, is a proprietary quercetin complex developed by Tesseract Medical Research. This advanced quercetin formulation contains other immuno-supportive compounds, such as zinc, vitamin C, and vitamin D3, to promote optimal immune function. Tesseract’s proprietary, groundbreaking CyLoc® – DexKey® nutrient delivery nanotechnology enables the optimal absorption of quercetin.
The CyLoc® technology encases individual quercetin molecules in its smart delivery system, and the accompanying DexKey® reactors release the molecules at the desired point in the intestinal tract to achieve maximum absorption. The unprecedented absorption of quercetin enables micro-dosing — using a lesser amount of quercetin than previously required to achieve a potent and immediate response.
The hypoallergenic, ionophore formula of QuerciSorb® Immuphore SR is one of the best quercetin supplements for promoting healthy immune function.* The formulation is manufactured following Good Manufacturing Practices (GMPs) and implements scientifically advanced analytical techniques and quality control systems to achieve the many health-promoting benefits of quercetin.*
The power of Tesseract supplements lies in enhancing palatability, maximizing solubility, absorption, and bioavailability, and micro-dosing a single or multiple nutrients in a single, highly effective capsule. Shop products on our website and learn more about how they support optimal immune function.*
References:
1Li Y, et al. Nutrients vol. 8,3 167. 15 Mar 2016, doi:10.3390/nu8030167
2,3,4Solnier J, et al. Evidence-based Complementary and Alternative Medicine: eCAM vol. 2023 9727539. 10 Aug 2023, doi:10.1155/2023/9727539
