Article Summary:
- Quercetin’s therapeutic efficacy is hindered by its naturally poor bioavailability and absorption.
- When considering the best quercetin supplement, you should look for optimal solubility, absorption, and bioavailability
- Tesseract’s proprietary quercetin supplement QuerciSorb® Immuphore SR utilizes the revolutionary CyLoc® – DexKey® nutrient delivery nanotechnology to overcome the nutrient’s natural absorption and bioavailability challenges.
Quercetin is critical forsupporting the immune system, iand functions by inhibiting histamine release, down-regulating proinflammatory cytokines, and inhibiting the creation of inflammatory mediators (leukotrienes).* Quercetin also plays an important role in supporting cardiovascular health and renal health.* Quercetin’s antioxidant and immunomodulatory properties make it a unique nutritional supplement.* However, the therapeutic properties of quercetin are hindered by its naturally low solubility and oral absorption. Therefore, supplement formulations use various delivery systems to overcome quercetin’s absorption and bioavailability challenges.
But what are the key properties of a supplement formulation you should look for when including a quercetin supplement in your diet? This article highlights several notable features of the best quercetin supplements.
Key Features of the Best Quercetin Supplements
Quercetin is a natural phytochemical compound found in vegetables (onions, tomatoes, broccoli, lettuce), fruits (apples, grapes, berries), nuts, and black and green tea. Although quercetin is abundantly present in various foods, its dietary intake in supplement form helps fill any nutritional gaps.
Quercetin is available in different chemical forms, including glycoside, glucuronide, sulfate, and methylated quercetin. Quercetin glucoside is relatively more soluble than other forms of quercetin because of the attachment of a glycosyl group that enhances its solubility in water. However, its bioavailability remains low, with an estimated absorption1 ranging between 3% – 17% in healthy individuals receiving 100 mg of the compound daily.
Formulated quercetin in the form of oral, intravenous, intranasal, and topical administration does enhance the stability of quercetin in the gastrointestinal environment and limits its intestinal degradation. In clinical studies, formulated quercetin displays a significant rise (more than 200%) in blood uptake compaired to unformulated quercetin.
The following table highlights the key features of the best quercetin supplement formulations for supporting immune health.*
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Best quercetin supplement: What to Look for | ||
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Solubility |
Absorption |
Bioavailability |
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The solubility of quercetin in aqueous solutions is low and pH-dependent. Supplement formulations delivered through liposomes, nanoemulsions, and micelles enhance the water solubility of quercetin. |
Quercetin is absorbed in the upper segment of the small intestine. Its absorption varies based on the type of formulation. Formulations containing quercetin-loaded nanoparticles display better absorption than other delivery systems. |
Enhancing the water solubility of quercetin also increases its bioavailability. Phospholipid complexes of quercetin increase the water solubility of the compound approximately 13-fold2, thereby increasing bioavailability significantly compared to free quercetin. |
In short, the best quercetin supplements reformulate free quercetin to enhance its solubility, absorption and bioavailability. While hydrophobic quercetin fits well into the lipid structure of a nanocarrier, liposomes protect the encapsulated quercetin from enzymes and extreme pH and temperature variations.
When you are considering including a quercetin supplement in your diet, make sure you select an advanced formulation that makes quercetin a therapeutic reality.
Including An Advanced Quercetin Formulation in Your Diet
QuerciSorb® Immuphore SR, developed by Tesseract Medical Research, is an advanced quercetin formulation for synergistically powerful and effective immune function support.* In addition to the proprietary quercetin complex, the Tesseract formula contains other immune-enhancing compounds, such as zinc, vitamin C, and vitamin D3. Tesseract’s formula has the advantage over other supplements with similar ingredients owing to its groundbreaking CyLoc® – DexKey® nutrient delivery nanotechnology.
The CyLoc® technology encases individual quercetin molecules in its smart delivery system, and the accompanying DexKey® reactors release the molecules at the desired point in the intestinal tract to achieve maximum absorption. The unprecedented absorption of quercetin enables micro-dosing — using a lesser amount of quercetin than previously required to achieve a potent and immediate physiological response. The hypoallergenic, ionophore formula of QuerciSorb® Immuphore SR provides all-day support to your immune function.*
The power of Tesseract supplements lies in enhancing palatability, maximizing absorption, and micro-dosing of multiple nutrients in a single, highly effective capsule. Shop products on our website and learn more about how they can help support your immune health.*
Citations
1Li Y, et al. Quercetin, inflammation and immunity. Nutrients vol. 8,3 167. 15 Mar. 2016, doi:10.3390/nu8030167
2Solnier J, et al. A pharmacokinetic study of different quercetin formulations in healthy participants: A diet-controlled, crossover, single- and multiple-dose pilot study. Evidence-based complementary and alternative medicine: eCAM vol. 2023 9727539. 10 Aug. 2023, doi:10.1155/2023/9727539
