Article Summary:
- Anandamide levels can become depleted due to several factors, including a sedentary lifestyle, a stress-induced environment, and an unhealthy diet.
- The natural production of anandamide in the body can be supported with an anandamide-rich diet, endurance exercises, and supplements.
- Tesseract’s proprietary CyLoc® – DexKey® technology enables unprecedented absorption of anandamide through the gut wall, making it a therapeutic reality.
Anandamide, the ‘bliss’ molecule cannabinoid naturally produced in the body, is known for its therapeutic properties in regulating emotional and mental well-being.* Chemically, anandamide is arachidonyl-ethanolamide (AEA), a lipid-based neurotransmitter that binds to endocannabinoid receptors in different regions of the brain and the body.* Although the exact mechanism of how anandamide works is not fully understood, research1 suggests that a suboptimal level of anandamide in the body can adversely influence our behavior and emotional health.*
If you are wondering how to boost anandamide levels in your body, let’s look at some of the common factors that impact your anandamide level, ways to enhance it, and why you should include an anandamide supplement in your diet.
How to Boost Anandamide Levels in Your Body: An Overview
The body’s natural production of anandamide is affected by the following factors:
- Enhanced activity of FAAH enzyme: The Fatty Acid Amide Hydrolase (FAAH) enzyme is a critical enzyme in the endocannabinoid system (ECS). The FAAH enzyme breaks down anandamide into ethanolamine and arachidonic acid. Genetic mutation in the FAAH gene is associated with inhibited activity of this enzyme, thereby limiting the breakdown of anandamide and increasing its level naturally. The issue is with excessive FAAH activity and subsequent depletion of anandamide resulting in loss of anandamide homeostasis.
- Stress-induced environment: Research2 indicates the adverse impact of high-stress environments on anandamide levels. Prolonged exposure to stressful environments results in the loss or downregulation of the CB1 receptors that bind to anandamide.
- Poor lifestyle choices: An irregular sleep schedule and a lack of physical activities can also deplete the body’s level anandamide.
As the level of anandamide dips, it can lead to mood changes, influencing our ability to cope with stress and anxiety (non-General Anxiety Disorder).* A low level of anandamide can also adversely impact heart, gut, and immune health.*
There are various ways to enhance the body’s natural production of anandamide. The following table highlights how to boost anandamide levels in your body.
How to Boost Anandamide Levels in Your Body |
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Anandamide-rich diet |
Cocoa beans and truffles are natural sources of anandamide, while other dietary sources, such as berries, apples, broccoli, Brussels sprouts, seafood, eggs, pepper, saffron, and tea, contain compounds that are precursors to anandamide production. |
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Active Lifestyle |
The ‘runner’s high’ experienced during and after endurance exercises is associated with the body’s release of endocannabinoids, including anandamide. The exercise-induced spike in peripheral anandamide levels helps maintain optimal anandamide production to promote neurological health. |
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Using CBD |
Cannabidiol (CBD) is a plant-derived cannabinoid that works indirectly with CB1 receptors of the endocannabinoid system (ECS) to enhance anandamide signaling. CBD also down-regulates the activity of the FAAH enzyme, thereby inhibiting anandamide degradation. However, it is worth noting that the use of CBD products is much debated. |
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Supplementation |
An anandamide supplement is a suitable alternative to CBD and can help fill nutritional gaps in the diet. Supplement formulations also enhance the absorption of anandamide and enable micro-dosing — the intake of a lesser amount of anandamide than previously required to achieve the desired physiological response. |
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The therapeutic benefits of anandamide are greatly hindered by its naturally poor absorption due to the instability of the anandamide molecule and the action of gastrointestinal enzymes on it. Supplement formulations that are based on advanced delivery systems, such as nanocarriers, enhance the absorption of anandamide molecules across the gut wall.
Including An Advanced Anandamide Supplement in Your Diet
AnaQuell® is a revolutionary anandamide supplement formulation developed by Tesseract Medical Research to support a healthy response to stress and anxiety (non-GAD).* So, what are the factors that make AnaQuell® stand out among commercially available anandamide supplements?
- Ingredients: In addition to anandamide, AnaQuell contains L-citrulline, the natural precursor of L-arginine, which is required for nitric oxide (NO) production. By enhancing NO production, L-citrulline promotes blood flow and nutrient delivery to the brain.
- Nano-molecular delivery science: The proprietary and groundbreaking CyLoc® – DexKey® technology solubilizes anandamide to ensure it is delivered through the gut wall.
- Unparalleled absorption and bioavailability: The unprecedented absorption of anandamide and its enhanced bioavailability allows for micro-dosing to achieve the desired therapeutic effects with lesser amounts of anandamide than previously required.
The power of Tesseract supplements lies in enhancing palatability, maximizing absorption and bioavailability, and nano-dosing multiple nutrients in a single, highly effective capsule. Shop products on our website and learn more about how they can help support your neurological health.*
Citations:
1Bluett RJ, et al. Translational psychiatry vol. 4,7 e408. 8 Jul. 2014, doi:10.1038/tp.2014.53
2Morena M, et al. Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology vol. 41,1 (2016): 80-102. doi:10.1038/npp.2015.166
