Article Summary:
- Studies indicate the potential benefits of nattokinase for promoting a normal gut microbiota.
- Advanced nattokinase supplements utilize nano-delivery technology to achieve the enzyme’s optimal absorption and bioavailability.
- Tesseract’s proprietary nutrient delivery nanotechnology enables targeted delivery of nattokinase to achieve its health-promoting benefits.
Natto, a soybean product fermented by the bacteria B.subtilis, has been a traditional food in Japan for hundreds of years and is often considered a key contributor to the longevity of the Japanese people. Although soybean, the raw material for natto, is itself a nutritious food with a high protein content, its cooking and subsequent fermentation produces easily absorbed active peptides, amino acids, oligosaccharides, and various enzymes.
The fermentation of natto produces enzymes like nattokinase andbacillopeptidase F, vitamin K2, and dipicolinic acid. In fact, natto contains more proteins, cellulose, calcium, iron, potassium, and vitamin B than soybeans.
Nattokinase, an enzyme produced by the bacteria involved in soybean fermentation, is known for its potential blood anti-clotting effects to promote heart health.*
Nattokinase has also been found to beneficially influence the gut microbiota, as well as exerting lipid-lowering and neuroprotective effects.* In this blog post, nattokinase’s gut health-supportive properties are described, and we suggest why you should include an advanced nattokinase supplement in your diet.
Understanding Nattokinase’s Gut Health-Supportive Properties
When nutritional supplements for gut microbiota are discussed, it is usually probiotics, prebiotics, and synbiotics that are identified as the popular choices. Natto is rich in dietary fiber and exerts beneficial effects on intestinal regulation.* Natto is expected to be an excellent probiotic because it contains B.subtilis var. natto itself.
Data from several human randomized controlled trials suggest potential benefits of natto on the gastrointestinal microbiota.* The following table highlights these studies that indicate nattokinase’s gut health-supporting properties:*
| Nattokinase and Gut Health: The Correlation | |
|---|---|
| Increase in the abundance of specific favorable bacteria in the gut microbiota postintake of a natto supplement.* | The intake of a natto supplement increased the relative abundance of Bifidobacterium and Blautia in males and Bifidobacterium in females. 1* Notably, the increased abundance of these bacterial strains was dependent on the relative baseline abundance of Bifidobacterium, regardless of sex. |
| Improved growth and viability of lactobacilli in the presence of B.subtilis var. Natto.* | B.subtilis var. Natto enhances the growth and viability of lactobacilli,* possibly through the production of the enzymes catalase and subtilisin. 2 |
| Positive effect of natto powder on obese rats fed a high-fat diet. | In an animal study, natto powder maintained the balance of cholesterol metabolism and beneficially regulated the gut microbiota in obese rats.* 3 |
| Nattokinase enhanced the preventive effects of Escherichia coli Nissle 1917 (EcN) to address adverse inflammation of the digestive tract.* | In a study examining the effects of nattokinase in enhancing the efficacy of EcN in colitis in mice, it was found that nattokinase potentially strengthened the capacity of EcN to address intestinal inflammation.* 4 |
| Bacillus subtilis natto alleviates intestinal barrier dysfunction.* | In a clinical study on high-fat-diet rats, Bacillus subtilis natto JLCC513 alleviated intestinal barrier dysfunction by inhibiting various cell signaling pathways and regulating gut microbiota conditions.* 5 |
Research indicates that nattokinase as a nutritional supplement exhibits fibrinolytic activity (the ability to limit blood clot formation).* However, because the enzyme’s large molecular size makes it prone to chemical oxidation and subsequent deactivation in the gastrointestinal tract, an advanced nattokinase supplement formulation that utilizes nano-delivery technology will enable the enzyme’s optimal absorption.
Including An Advanced Nattokinase Supplement in Your Diet
NattoGuard® is an innovative nattokinase nutritional supplement developed by Tesseract Medical Research to support gastrointestinal health. How does NattoGuard differ from other nattokinase supplements available in the market?
- Enhanced bioavailability: Tesseract’s proprietary CyLoc® —DexKey® nutrient delivery nanotechnology enhances nattokinase’s bioavailability by protecting it from degradation during transit through the stomach. The CyLoc® technology encases each nattokinase molecule and creates nano-sized particles to protect them from breaking down during transit through the stomach.
- Targeted delivery: The accompanying DexKey® reactors release the CyLoc®-enclosed nattokinase molecules at the desired point in the intestinal tract. The resulting unprecedented absorption and optimal bioavailability of nattokinase achieve its health-promoting potential.
At Tesseract Medical Research, our commitment to Good Manufacturing Practices (GMPs) and a well-designed quality control system ensures that you receive the finest quality nutritional supplements.
The power of Tesseract supplements lies in enhancing palatability, maximizing solubility, absorption, and bioavailability, and micro-dosing a single or multiple nutrients in a single, highly effective capsule. Shop products on our website and learn more about how they support gastrointestinal health.*
References:
1Kono K, et al. Nutrients vol. 14,18 3839. 16 Sep. 2022, doi:10.3390/nu14183839
2Hosoi T, et al. Canadian Journal of Microbiology vol. 46,10 (2000):892-897. doi:10.1139/w00-070
3Sun R, et al. Journal of Applied Microbiology vol. 135,2 (2024): lxae003. doi:10.1093/jambio/lxae003
4Liang M, et al. World Journal of Microbiology & Biotechnology vol. 39,1 8. 9 Nov. 2022, doi:10.1007/s11274-022-03452-9
5Sun R, et al. Journal of Applied Microbiology vol. 133,6 (2022):3634-3644. doi:10.1111/jam.15797
