Article Summary:
- Specific vitamins, minerals, and specific compounds exert vasculoprotective effects that promote healthy arteries and veins.*
- The efficacy of the active nutrients in nutritional supplements for vascular health depends on the nutrients’ absorption and bioavailability.
- The proprietary nutrient delivery nanotechnology developed by Tesseract Medical Research enables the targeted delivery of active nutrients to optimize their solubility.
Arteries and veins form the intricate network of blood vessels in the body that sustain the circulatory system, ensuring the efficient transport of oxygen, nutrients, hormones, and metabolic waste throughout the body. The body’s vasculature includes the major arteries, such as the aorta, as well as smaller arteries, arterioles, capillaries, post-capillary venules, and collecting central veins. Several factors, including diet, lifestyle, aging, stress, injury, family history, and certain health conditions, can significantly impact vascular integrity and overall cardiovascular function. Impaired vascular health can contribute to endothelial dysfunction, arterial stiffness, and an increased risk of cardiovascular and cerebrovascular disease.
While a balanced diet and regular physical activity are vital in maintaining vascular health, specific nutrients and bioactive compounds have been shown to support endothelial function, enhance nitric oxide production, mitigate oxidative stress, and improve microcirculation. This post discusses several key nutritional supplements for promoting arterial and venous health, and why you should include an advanced supplement formulation for optimal absorption and bioavailability of the supplement’s active ingredients.*
Active Nutrients in Supplements that Support Arteries and Veins
Vitamins, minerals, and other specific compounds are known to exert vasculoprotective effects.* Vitamin B3, folic acid, vitamins C and E, beta-carotene, and minerals, such as selenium and zinc, are associated with promoting cardiovascular health, including healthy arteries and veins.* The following table highlights the effects of several compounds, other than vitamins and minerals, used as active nutrients in supplements that support healthy arteries and veins.*
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Active Nutrients in Supplements for Healthy Arteries and Veins |
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| Nattokinase: The potent enzyme nattokinase, which is released during the fermentation of soybeans, has several beneficial effects on the cardiovascular system.* Nattokinase has been found to help maintain healthy arteries by lowering lipid peroxidation, maintaining normal blood viscosity, and enhancing lipid metabolism.*1 |
| Anandamide: This endocannabinoid shows the potential to inhibit neurogenic vasodilation of dural blood vessels in the brain.* The hypotensive mechanism of action of anandamide is associated with the excitation of sensory nerves and the release of vasodilator peptides to induce vasodilation of isolated arteries.*2 |
| Coenzyme Q10: CoQ10 is an endogenously synthesized compound that acts as an electron carrier in the mitochondrial electron transport chain.* As an antioxidant, CoQ10 enhances endothelial function by reducing the source of reactive oxygen species (ROS) in the vascular system and enhancing nitric oxide levels for vasodilation.* It is suggested that CoQ10 improves vascular function and helps maintain normal blood pressure levels in specific health conditions characterized by elevated oxidative and nitrosative stress.*3 |
| L-Citrulline: This amino acid is produced by the body and is a precursor of L-arginine, a substrate for endothelial nitric oxide synthase (eNOS) — a key enzyme and signaling molecule that helps regulate various cardiovascular functions. L-citrulline increases vasodilation and blood flow through increased NO production.* A study on the efficacy of L-citrulline on arterial health in middle-aged men suggested that short-term L-citrulline supplementation functionally improves arterial health, independent of blood pressure.*4 |
| Lipoic Acid: This fatty acid is an antioxidant produced by the body and is also available in various dietary sources. In a study evaluating the effect of alpha-lipoic acid (ALA) on vascular function, it was found that ALA enhances endothelial function by increasing the bioavailability of endothelium-derived nitric oxide, lowering oxidative stress, and down-regulating adverse inflammatory responses in the vascular cells.*5 |
| Quercetin: Quercetin, a natural antioxidant and a major flavonoid, is abundantly found in fruits and vegetables. Research indicates that quercetin helps lower oxidative stress and exerts vasculoprotective effects through the up-regulation of endothelial nitric oxide synthase (eNOS) and activation of the adenosine monophosphate-activated protein kinase (AMPK) pathway.*6 |
The efficacy of the above active nutrients as ingredients in nutritional supplements aimed at promoting healthy arteries and veins depends on their optimal absorption and bioavailability.* Targeted delivery of these nutrient molecules through nanotechnology enhances the solubility of the active nutrients.
Selecting An Advanced Supplement for Vascular Health
The CyLoc® —DexKey® technology developed by Tesseract Medical Research is a nutrient delivery nanotechnology that maximizes the absorption and bioavailability of nutrients. Tesseract’s innovative technology protects the nutrient molecules from early degradation in the stomach, while ensuring their targeted delivery at the desired point in the intestinal tract for unprecedented absorption.
Tesseract Medical Research has developed several advanced supplements for promoting healthy arteries and veins utilizing this proprietary technology. The following are some of Tesseract’s key supplement formulations for promoting good vascular health.
- NattoGuard™: This advanced nattokinase formulation supports optimal cardiovascular function.*
- AnaQuell™l: This anandamide supplement supports a healthy response to stress and mild (non-GAD) anxiety and promotes mental well-being.*
- CoQ10 Pro®: This formulation optimizes CoQ10 transport and absorption to promote cardiovascular and mitochondrial health.*
- NOX-Flo SR™: This combination supplement utilizes L-citrulline, CoQ10, and R-lipoic acid to promote healthy nitric oxide synthesis and support optimal circulatory health.*
- QuerciSorb®: This innovative quercetin complex promotes a healthy immune response and optimal cardiovascular function.*
All Tesseract nutritional supplements are manufactured following Good Manufacturing Practices (GMPs), including the most advanced analytical techniques and a well-designed quality control system.
The power of Tesseract supplements lies in enhancing palatability, maximizing solubility, absorption and bioavailability, and micro-dosing a single or multiple nutrients in a single, highly effective capsule. Shop products on our website and learn more about how they support cardiovascular health.*
References:
1Iwai K, et al. Antioxidative functions of natto, a kind of fermented soybeans: effect on LDL oxidation and lipid metabolism in cholesterol-fed rats. Journal of Agricultural and Food Chemistry vol. 50,12 (2002):3597-3601. doi:10.1021/jf0117199
2Zygmunt PM, et al. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature vol. 400,6743 (1999):452-457. doi:10.1038/22761
3Hodgson JM, Watts GF. Can coenzyme Q10 improve vascular function . . . ? Potential for effective therapeutic reduction in vascular oxidative stress. BioFactors (Oxford, England) vol. 18,1-4 (2003):129-136. doi:10.1002/biof.5520180215
4Ochiai M, et al. Short-term effects of L-citrulline supplementation . . . in middle-aged men. International Journal of Cardiology vol. 155,2 (2012):257-261. doi:10.1016/j.ijcard.2010.10.004
5Hajizadeh-Sharafabad F, Zahabi ES. Role of alpha-lipoic acid in vascular function: A systematic review of human intervention studies. Critical Reviews in Food Science and Nutrition vol. 62,11 (2022):2928-2941. doi:10.1080/10408398.2020.1861425
6Shen Y, et al. Quercetin and its metabolites improve vessel function by inducing eNOS activity via phosphorylation of AMPK. Biochemical Pharmacology vol. 84,8 (2012):1036-1044. doi:10.1016/j.bcp.2012.07.016
